| Research Topics: |
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Scanned: 2759 Evaluated: 288 Selected: 68 |
| GENETICS KIDNEYS | ||||||||
Mge03-020 | Integrative kidney multi-omics traces genetic drivers of chronic kidney disease to targets within the renal epigenome, transcriptome and proteome | |||||||
| Quote: | We found evidence for genetic regulation of developmental DNA methylation patterns that determine kidney health later in life. Finally, through analysis of Isolated Hyperchlorhidrosis - a rare genetic syndrome associated with Carbonic Anhydrase 12 a novel CKD kidney gene - we uncovered new metabolic consequences of genetic CA12 loss hyperuricemia, reduced kidney function and illuminated adverse effects of CA12-inhibitors acetazolamide. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.15.26344229v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.15.26344229v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Amber Emmett Xiaoguang Xu Xiao Jiang Shadi Hames-Fathi David Scannali James M Eales Ewa Miller-Kasprzak Polly Downton Antony Adamson Yong Sun Abigail C Lay David Talavera Matthew Denniff John Dormer Grzegorz Rempega Robert Krol Sebastien Rubin Joanna Zywiec Wojciech Wystrychowski Pawel Bogdanski Cristian Pattaro Nilesh Samani Bernard Keavney Tomasz Guzik Rachel Lennon Andrew P Morris Fadi Charchar Maciej Tomaszewski, | |||||||
| GENETICS PSYCHOLOGY | ||||||||
Mpy03-008 | Mapping unexplained genetic correlations across 14 psychiatric disorders | |||||||
| Quote: | Conc: Conclusions Higher-order genetic factors explain broad shared liability but leave meaningful, structured residual links between specific disorder pairs. OCD and ADHD are robust residual hubs, highlighting candidate cross-disorder connections for targeted phenotypic harmonization, cross-phenotype GWAS, and theory-guided model refinements. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.14.26344089v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.14.26344089v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Yu Chang Ming-Hong Hsieh Po-Chung Ju Cheng-Chen Chang, | |||||||
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01/24/2026-02:51:25 AM
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