Research
Topics:
INDEX
AI-chat 4
MCS 1
PRIME 19
PRIO 1
aging 13
brain 12
cancer 7
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cognition 6
covid-19 3
culture 1
dental 1
diabetes 5
diagnostics 4
gender 1
genetics 5
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heart 10
herbs 2
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metabolism 2
microbiome 3
nutrition 7
pain 2
politics 4
pollution 1
population 1
practice 1
psychology 6
reproduction 2
sleep 3
soc-media
tech 1
unk
war-confl
 
Scanned: 2728
Evaluated: 299
Selected: 66

 
    AGING    BRAIN    DIAGNOSTICS   

Mcr04-006

Brain Perivascular Spaces Reflect Neuropsychological and Shared Familial Microvascular Architecture Beyond Vascular Risk

Quote:Conclusions PVS morphology reflects neuropsychiatric and shared familial microvascular architecture, with both inherited and individual factors contributing to PVS burden and morphometry, and supporting the use of PVS morphometry as a neuroimaging marker of cerebral microvascular health.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.22.26344665v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.22.26344665v1.full-text
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Search Authors: Alexandra Morozova Maria del C. Valds Hernndez ROBERTO DE JESUS DUARTE COELLO Heather Whalley Andrew McIntosh Anca-Larisa Sandu Gordon Waiter Christopher J. McNeil Douglas Steele Jennifer A Macfarlane Alison D Murray Joanna M. Wardlaw, 
    AGING    BRAIN    COGNITION   

Mcr04-024

Stroke Subtypes Drive Distinct Neurological, Cognitive, and Mortality Outcomes in UK Biobank Cohort

Abstract: https://www.medrxiv.org/content/10.64898/2026.01.25.26344805v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.25.26344805v1.full-text
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Search Authors: Ambika Grover Venkatesh L. Murthy Chirag J. Patel, 
    AGING    GENETICS   

Mep04-034

Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimers disease neurodegeneration

Abstract: https://www.medrxiv.org/content/10.64898/2026.01.23.26344650v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.23.26344650v1.full-text
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Search Authors: Linda K. McEvoy Bowei Zhang Steve Nguyen Adam X. Maihofer Caroline M. Nievergelt Ramon Casanova Steve Horvath Ake T. Lu Christos Davatzikos Guray Erus Susan M. Resnick Mark A. Espeland Stephen R. Rapp Kenneth Beckman Luigi Ferrucci Andrea Z. Lacroix Aladdin H. Shadyab, 
    AGING    BRAIN    COGNITION   

Mne04-002

Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK Biobank

Quote:suggesting that unfavorable lifestyle may have a greater impact in individuals without genetic risk. No significant interactions were found in cognitive or imaging models. Conclusion: The APOE #1013;4 genotype was the strongest single predictor of dementia and cognitive outcomes. In contrast, the LIBRA2 index was most strongly associated with processing speed and neuroimaging markers, demonstrating its critical role in non-diagnostic brain health outcomes. These findings highlight the complementary and domain-specific contributions of genetic and lifestyle factors in dementia risk modeling.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.23.26344680v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.23.26344680v1.full-text
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Search Authors: Yidan Zhang Gamze Erzin Colin Rosenau Sebastian Kohler Dennis van der Meer Jurjen J Luykx David E.J Linden Bart P.F Rutten Sinan Guloksuz Gabriella A.M Blokland, 
    PRIME    AGING    COGNITION    SLEEP   

Mne04-010

REM Sleep is Associated with Cognition and Biomarkers Longitudinally in Older Adults Across the Alzheimer Disease Continuum

Quote:Longitudinal data, spanning up to 16 years, demonstrated that the rate of change in cognition and AD biomarkers in the time preceding PSG assessment was also strongly associated with REM characteristics. Our findings highlight the potentially bidirectional relationship between the accumulation of AD pathology and the disruption of REM sleep.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.22.26344642v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.22.26344642v2.full-text
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Search Authors: Valentina Pinilla Era Laho Stephanie Marvin Yazmeen Usman Michael Properzi Kailee Palmgren Yiwen Rao Wai-Ying Wendy Yau Gretchen Reynolds Keith Johnson Rachel Buckley Dorene Rentz Rebecca Amariglio Susan Redline Shaun M Purcell Reisa Sperling Ina Djonlagic Jasmeer Chhatwal Stephanie Schultz, 
    AGING    BRAIN   

Mne04-020

Increased aperiodic offset and heightened alpha power characterize resting-state EEG activity in Parkinsons disease

Quote:esults Aperiodic offset and alpha power were higher in patients than controls across all channels BF1072.41; BF1020.45 and when restricting analysis to pericentral sensorimotor channels BF1063.01; BF1012.06. These differences were expressed in patients with and without levodopa-induced dyskinesias and replicated at follow-up. In patients, aperiodic offset and exponent, but not periodic alpha or beta power, scaled positively with age and disease duration BF102.169.76. Conclusions PD is associated with changes in resting-state brain activity, reflected in both aperiodic and periodic EEG activity. The finding that aperiodic parameters scale with age and disease duration suggests that aperiodic EEG features may serve as markers of disease progression, complementing traditional periodic measures.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.20.26343832v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.20.26343832v1.full-text
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Search Authors: Salvatore Bertino Amin Ghaderi-Kangavari David Meder Mikkel Christoffer Vinding Nora Raaf Lasse Christiansen Birgitte Liang Chen Thomsen Annemette Lkkegaard Angelo Quartarone Mikkel Malling Beck Hartwig Roman Siebner, 
    AGING    BRAIN   

Mne04-026

Intracerebral hemorrhage induces monocyte TNF signaling that is suppressed by Siponimod BAF312: a single-cell transcriptomics study in patients

Abstract: https://www.medrxiv.org/content/10.64898/2026.01.22.26344292v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.22.26344292v1.full-text
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Search Authors: Jonathan Howard DeLong Sebastian Diaz-Perez Kevin N Sheth Jang-Ho Cha CJ Malanga Patricia GM Wagner Nicole Pezous Aurelie Hanin Kyle B Walsh H.E. Hinson Lauren Hachmann Sansing, 
    AGING    COGNITION   

Mne04-030

Life-course Stress Exposure and Cognitive Decline in Middle-aged and Older Chinese Adults: The Role of Sex Differences and Educational Protection

Quote:onclusion Life-course stress exposure, particularly when cumulative, is associated with accelerated cognitive decline in Chinese middle-aged and older adults. Women show greater vulnerability to stress-related cognitive effects, whereas higher education appears to buffer against such impacts across both sexes. These findings underscore the importance of sex-sensitive, education-informed approaches to stress reduction and cognitive health promotion across the life course.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.26.26344833v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.26.26344833v1.full-text
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Search Authors: Jiahao Li Giulia Mozzanica Feng Zhang Jocelien D.A. Olivier Ulrich L.M. Eisel, 
    AGING    BRAIN   

Mne04-034

Orthostatic hypotension in Parkinsons disease impacts the association between white matter lesion volume and motor symptom burden

Quote:Conclusions The presence of OH in PWP impacts the links between white matter lesion volume and motor symptom burden. These findings may provide a potential mechanism underlying the poorer disease prognosis among PWP with OH.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.25.26344797v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.25.26344797v1.full-text
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Search Authors: John DAmico Miriam Sklerov Eran Dayan, 
Search Words:
OH Orthostatic Hypotension Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
white matter hyperintensity WMH Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
persons with Parkinsons disease PWP. Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    AGING    BRAIN   

Mne04-036

Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimers disease

Abstract: https://www.medrxiv.org/content/10.64898/2026.01.25.26344738v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.25.26344738v1.full-text
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Search Authors: Konstantinos Chiotis Ganna Blazhenets David N. Soleimani-Meigooni Paul S. Aisen Alinda Amuiri Alireza Atri Laurel Beckett Michael Brickhouse David G. Clark Jeffrey L. Dage Gregory S. Day Ranjan Duara Ani Eloyan Tatiana Foroud Neill R. Graff-Radford Ian M. Grant Dustin B. Hammers Lawrence S. Honig Erik C. B. Johnson David T. Jones Kala Kirby Robert Koeppe Joel H. Kramer Walter A. Kukull Julien Lagarde Antoine Leuzy Piyush Maiti Joseph C. Masdeu Mario F. Mendez Erik Musiek Kelly N. Nudelman Chiadi U. Onyike Meghan Riddle Salma Rocha Emily Rogalski Stephen Salloway Daniel R. Schonhaut Sharon Sha Ranjani Shankar Alexander Taurone Maryanne Thangarajah Arthur W. Toga Alexandra Touroutoglou Raymond Scott Turner Prashanthi Vemuri Thomas S. Wingo David A. Wolk Kyle Womack Jiaxiuxiu Zhang Maria C. Carrillo Bradford C. Dickerson Liana G. Apostolova Renaud La Joie Gil D. Rabinovici span classnlm-collab data-hwp-idcollab-1the Longitudinal Early-onset Alzheimers Disease Study consortium and the Alzheimers Disease Neuroimaging Initiative, 
    AGING   

Mot04-002

First Real-World Evidence Utilizing the Multidimensional Tinnitus Functional Index to Assess Treatment Impact with Bimodal Neuromodulation

Quote:Conclusions This retrospective study demonstrates that 12 weeks of treatment with the Lenire device resulted in clinically meaningful improvements in tinnitus severity on the TFI which was strongly supported by the THI. The high correlation between TFI and THI change scores indicates strong correlation between the two questionnaires in capturing treatment effects. Furthermore, all eight TFI subdomains showed notable reductions, underscoring the multidimensional impact of the treatment. These findings support the clinical utility of both the TFI and THI as complementary tools for evaluating treatment outcomes and guiding tinnitus management in routine practice
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.20.26344445v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.20.26344445v1.full-text
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Search Authors: Miles Sabine Brian Fligor, 
Search Words:
innitus Functional Index TFI Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Tinnitus Handicap Inventory THI Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    AGING    BRAIN   

Mre04-002

Differential Effects of Cognitive vs. Motor Dual-Task Training in Stroke Rehabilitation: A Precision-Focused Meta-Analysis

Quote:These results offer crucial prescriptive insights, guiding clinicians to match the dual-task modality and timing of intervention to the individual patients functional profile. However, the high heterogeneity among studies and the lack of direct comparative trials between CDT and MDT limit the conclusive strength of these recommendations.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.23.26344517v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.23.26344517v1.full-text
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Search Authors: Hui Gao Man Lang Mustapha Mangdow Wen Liu, 
    AGING    BRAIN    LANGUAGE   

Mre04-004

Machine Learning Driven Therapy Calculator for Self-Managed Digital Speech-Language Therapy for Individuals with Post-stroke Aphasia

Abstract: https://www.medrxiv.org/content/10.64898/2026.01.22.26344656v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.22.26344656v1.full-text
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Search Authors: Hantian Liu Margrit Betke Prakash Ishwar Swathi Kiran, 

  Updated weekly. 01/31/2026-02:32:41 AM
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