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PRIME
BRAIN
GENETICS
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Mge05-010 | Nonlinear dynamic genetic regulation identifies peripheral drivers of neurodegenerative disease progression |
| Quote: | xtending 2sGen-GPS to Alzheimers disease, we identified 328 genes linked to cognitive decline and prioritized drug compounds capable of reversing these expression signatures. Our study elucidates how dynamic genetic effects shape the trajectories of NDD-related traits and nominates peripherally accessible, causal genes as promising therapeutic targets for modulating disease progression.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.29.26345161v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.29.26345161v1.full-text |
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| Search Authors: |
Junfeng Luo Hao Wu Wenxuan Du span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative Ganqiang Liu,
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AGING
BRAIN
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Mne05-002 | Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases |
| Quote: | An early cortico-limbic/late basal ganglia subtype represented a dementia-prone subtype across clinical diagnoses, with limbic involvement associating with the emergence of visual hallucinations. These biologically relevant spatiotemporal atrophy subtypes provide an interpretable stratification of patients with LBD, with potential to refine prognosis, improve clinical trial stratification, and guide precision therapeutic approaches.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.29.26344990v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.29.26344990v1.full-text |
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Ajay Konuri Gonzalo Castro Leal Niloufar Zebarjadi Annegret Habich Nicolas Castellanos-Perilla Maria Camila Gonzalez John-Paul Taylor Michael Firbank Daniel Alcolea Alexandre Bejanin Kurt Segers Florence Benoit Ahmet Turan Isik Bedia Samanci Consuelo Chafer-Pericas Richard Wade-Martins Michele T M Hu Rohan Bhome Ivelina Dobreva Zuzana Walker Dag Aarsland Eric Westman Daniel Ferreira Glenda Halliday Simon JG Lewis Rimona S Weil Ramon Landin-Romero Christian Lambert Neil P Oxtoby Elie Matar,
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BRAIN
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Mne05-022 | A Surgical Planning Pipeline for Human Implantable Brain-Computer Interfaces |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.01.26345325v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.01.26345325v1.full-text |
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Peter N Hadar Jian Li Brian Coughlin William Munoz Brian Hsueh Ziv M Williams Seonghwan Yee Otto Rapalino David Brandman Sergey D Stavisky Jaimie M Henderson Francis R Willett Daniel B Rubin Leigh R Hochberg Sydney S Cash Eun Young Choi Angelique C Paulk,
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BRAIN
PAIN
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Mne05-024 | Neural and psychophysical predictors of treatment response to transcranial direct current stimulation and mindfulness-based meditation for knee osteoarthritis pain |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.02.26345407v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.02.26345407v1.full-text |
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| Search Authors: |
Chiyoung Lee Juyoung Park Hongyu Miao Hyochol Ahn,
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AGING
BRAIN
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Mne05-026 | CSF turnover reshapes biomarker interpretation in neurodegeneration studies |
| Quote: | Cerebrospinal fluid CSF biomarkers are central to Alzheimers disease AD diagnosis and research. ... CSF turnover/clearance severely impacted core AD biomarker levels, affecting the classification of subjects in the A/T framework. Adjusting biomarker levels for OPCML, a novel reference marker, improved biomarker-based prediction of AD progression and removed confounded associations, revealing a proteomic signature of sporadic AD pathology that closely resembles that of autosomal dominant AD.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.02.26345363v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.02.26345363v1.full-text |
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Pablo Garcia-Gonzalez Raquel Puerta Jonas Dehairs Chengran Yang Ciyang Wang Jigyasha Timsina Itziar de Rojas Claudia Olive Alejandro Valenzuela Paula Bayon-Bujan Marta Rovira Laura Montrreal Maria Capdevila Alvaro Munoz-Morales Berta Calm Sergi Valero Montse Alegret Marta Marquie span classnlm-collab data-hwp-idcollab-1The Global Neurodegeneration Proteomics Consortium GNPC John C Morris Suzanne E Schindler David M Holtzman Pilar Sanz Lluis Tarraga Asif Khan Maria Eugenia Saez Bart Smets Adelina Orellana Xavier Montalban Merce Boada Amanda Cano Menghan Liu Muhammad Ali Carlos Cruchaga Johannes V Swinnen Victoria Fernandez Alfredo Cabrera-Socorro Agustin Ruiz,
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BRAIN
CULTURE
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Zac05-011 | Where Science Has Never Gone Before: Were Learning What its Like to Die |
| Quote: | Is this burst of electrical energy in the brain in the moments before death significant? The heightened burst of activity as the brain responds to the lack of oxygen is centered in the temporo-parietal-occipital areas of the brain; the parts of the brain that are typically associated with consciousness. Something is happening in our conscious mind when the brain realizes that death is near.
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| Article:
| https://pjmedia.com/rick-moran/2026/02/06/where-science-has-never-gone-before-were-learning-what-its-like-to-die-n4949204 |
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