Research
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INDEX
AI-chat 1
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PRIME 29
aging 11
arts 1
brain 10
brainwave 2
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covid-19 1
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lungs 1
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nutrition 1
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psychology 5
reproduction 2
sleep 1
soc-media
unk
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virus 2
war-confl
 
Scanned: 2706
Evaluated: 166
Selected: 52
 
    PRIME    AGING    BRAIN    IMMUNE   

Aaa06-005

The Amazing Benefits of Spermidine

Quote:In recent years, spermidine has emerged as a compound of interest in longevity and nutrition science, largely due to its role in autophagy, the bodys cellular cleanup system. However, spermidines importance extends well beyond general anti-aging mechanisms. In the brain, spermidine belongs to a class of molecules called polyamines, which play a critical role in regulating how brain cells communicate, adapt, and remain resilient over time. What are polyamines? Understanding spermidines neurological relevance begins with understanding what polyamines are and how they function in the nervous system.
Article: https://richardgoldberg.substack.com/p/the-amazing-benefits-of-spermidine
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Search Authors: Richard Goldberg,  Felton Nutrition, 
Search Words:
spermidine Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
autophagy Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
polyamines nervous system Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    AGING    BRAIN    NUTRITION   

Aaa06-006

Common household plant could hold key to fighting Alzheimers disease

Quote:Aloe vera, a rubbery green plant, may be best known for its skin-soothing qualities, but a study published in Current Pharmaceutical Analysis suggests that key chemicals within the plant could interact with enzymes involved in Alzheimers disease, hinting at a new approach to disrupting cognitive breakdown. A chemical messenger in the brain called acetylcholine, which helps nerve cells communicate, is reduced in Alzheimers patients, contributing to memory loss and cognitive decline, according to the study press release.
Comment: Computer simulations ("in silico") suggest that Beta sitosterol and Succinic acid emerge as potential drug candidates for Alzheimers disease. Incredible hype all over the internet, but no human or even lab rat tests. Succinic acid is a known chelating agent, and chelation does improve many conditions. Chelation rejuvinates the mitochondria, the energy powerouse of our cells. I have had Chelation, felt the amazing Rejuvination toward the end of the series.
Article: https://www.foxnews.com/health/common-household-plant-aloe-vera-could-hold-key-fighting-alzheimers-disease
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Search Words:
Beta sitosterol and Succinic acid Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Beta sitosterol Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Succinic acid Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
chelation Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
See Also:
  • https://www.sciencedaily.com/releases/2026/02/260206012213.htm
    •     PRIME    AGING    BRAIN    EXERCISE    SOC-MEDIA   

    Aaa06-007

    Scientists reveal the one practice that could prevent dementia as you age Ifrequent social contact raises neurological risk in older adunlts, study finds

    Quote:The study concluded that social frailty was associated with a higher risk of dementia, with socially frail individuals facing about a 47 increased risk compared to those in the non-frail group. In most socially frail people, the factors that were most strongly associated with this risk included low financial and family satisfaction, infrequent social contact and limited participation in social activity. ... The experts noted that mental and physical exercise are also crucial for keeping the brain young and sharp.
    Comment: HINT: Want social activity? You could email me... Javilk, same name/ID as the web site. Tell me what you think and what you are interested in.
    Article: https://www.foxnews.com/health/scientists-reveal-one-practice-could-prevent-dementia-you-age
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        AGING    IMMUNE   

    Mep06-014

    Circulating Cell Type Senescence Signatures Reveal High-Resolution Health Status and Trajectories in Human Longitudinal Studies

    Quote:Notably, pooled senescence proteins outperformed non-senescence proteins in predicting many clinical parameters such as age and hypertension, and in many instances cell type senescence signatures mapped most strongly to their corresponding health domain. Importantly, the immune cell senescence signature is associated with future onset of several diseases such as diabetes. This study demonstrates that circulating cell type-specific biomarkers of senescence can reveal higher resolution health status than previously attained.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345739v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345739v1.full-text
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    Search Authors: Bradley Olinger Carlos Anerillas Allison B. Herman Dimitrios Tsitsipatis Reema Banarjee Toshiko Tanaka Julian Candia Manolis Maragkakis Stefania Bandinelli Keenan A. Walker Eleanor M. Simonsick Yue A Qi Luigi Ferrucci Myriam Gorospe Nathan Basisty, 
        PRIME    AGING   

    Mep06-020

    The plasma proteins GSN, F2, CRTAC1, and HP reflect multigenerational health, longevity, and resilience

    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345744v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345744v1.full-text
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    Search Authors: Pasquale C. Putter Marian Beekman Nico Lakenberg Jan-Wilm Lackmann Stefan Mller Roman-Ulrich Mller Joris Deelen P. Eline Slagboom Philipp Antczak Niels M.A. van den Berg, 
        AGING   

    Mgr06-002

    Low-frequency oscillations in postural sway may have prognostic value for fall risk assessments in aging

    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345669v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345669v1.full-text
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    Search Authors: M. Meyer Vega HN. Rizeq DJ. Goble PE. Gilbert N. Valadi N. Baweja HS. Baweja, 
        PRIME    AGING    BRAIN   

    Mgr06-004

    Associations of amyloid biomarkers with brain and cognitive changes from imaging, spinal fluid, and plasma

    Quote:DISCUSSION Using different measurement methods, amyloid was not consistently associated with volumetric or cognitive measures. Our findings also suggest that plasma markers may not be associated with cognitive and brain changes in the same manner as CSF and PET.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1.full-text
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    Search Authors: Jason Scully Mahsa Dadar Cassandra Morrison span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative, 
        PRIME    AGING   

    Mne06-006

    Predictive Value of Plasma P-tau217 and APOE Genotype for Preclinical Cognitive Decline in Alzheimers Disease

    Quote:Conclusions Plasma P-tau217 levels and the presence APOE genotype can be used to estimate the interval before the onset of overt cognitive impairment and the diagnosis of AD. The findings here support the use of commercially available APOE genotyping and plasma P-tau217 to determine optimal timing for therapeutic intervention, particularly during the preclinical phase of the disease.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345774v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345774v1.full-text
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    Search Authors: Yuexuan Xu Tamil Iniyan Gunasekaran Yian Gu Dolly Reyes-Dumeyer Angel Piriz Danurys Sanchez Diones Rivera Mejia Martin Medrano Rafael A. Lantigua Lawrence Honig Rachael Wilson Ramiro Eduardo Rea Reyes Jennifer J Manly Adam M. Brickman Corinne D. Engelman Sterling Johnson Sanjay Asthana David A. Bennett Melissa Petersen Sid OBryant Badri N. Vardarajan Richard Mayeux, 
        PRIME    AGING    BRAIN   

    Mne06-008

    The prognostic value of blood-based p-tau217 levels on progression to clinical impairment

    Quote:Elevated p-tau217 associated with accelerated cognitive decline, both independent of, and synergistic with, greater A#946;-PET. These findings establish plasma p-tau217 as a robust prognostic marker in preclinical AD and support its value in future individualized risk prediction.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1.full-text
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    Search Authors: Rachel F. Buckley Diana L. Townsend Colin J. Birkenbihl Madison Cuppels Gillian T. Coughlan Mabel T. Seto Jane A. Brown Michael J. Properzi Merle C. Hnig Annie Li Aaron P. Schultz Jasmeer Chhatwal Hyun-Sik Yang Steven Arnold Pia Kiviskk Bryan D. James Sid OBryant Robert A. Rissman Melissa Petersen Jessica Z. K. Caldwell Tobey Betthauser Julie Elisabeth Oomens Maria Carrigan Brian Healy Jorge Garcia Condado Sterling Johnson Wai-Ying Wendy Yau Oliver Langford Michelle Farrell Rebecca E. Amariglio Dorene M. Rentz Kathryn V. Papp Timothy J. Hohman Michael Donohue Paul S. Aisen Keith A. Johnson Reisa A. Sperling, 
        PRIME    AGING    COGNITION    HEART   

    Mph06-002

    A Novel Drug-Drug Interaction: Dihydropyridine Calcium Channel Blockers Amplify Gabapentin-Associated Dementia Risk

    Quote:Conc: Conclusions We identified a novel drug-drug interaction whereby DHP CCB co-medication amplifies gabapentin-associated dementia risk, confirmed by time-varying analysis Rate Ratio1.65. The DHP-specific signal is biologically plausible given independent evidence that DHP CCBs may adversely affect cognition DREAM consortium, while the absence of interaction with verapamil aligns with its potential neuroprotective properties identified in drug repurposing studies. The F03-specific pattern suggests drug-induced cognitive impairment that may be reversible. These hypothesis-generating findings identify gabapentin-DHP CCB combinations as a target for cognitive safety monitoring and warrant confirmation with concurrent exposure measurement
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1.full-text
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    Search Authors: James W Green Suril Gohel Barbara Tafuto Luciana Mascarenhas Fonseca Michal Schnaider Beeri Sharon Sanz Simon James Scott Parrott Branimir Ljubic Michael Schulewski, 
        PRIME    AGING    BRAIN    COGNITION    PSYCHOLOGY   

    Mpy06-020

    Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC

    Quote:Introduction Lactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex dACC, a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. ... establishes a metabolic stress-testing paradigm for detecting latent neuroenergetic vulnerabilities, supporting fMRS utility for probing mitochondrial function in health and psychiatric disorders.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1.full-text
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    Search Authors: Edward Caddye Joel Patchitt Anouk Schrantee William T Clarke Itamar Ronen Alessandro Colasanti, 

      Updated weekly. 02/13/2026-07:20:23 PM
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