Research
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unk
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war-confl
 
Scanned: 2706
Evaluated: 166
Selected: 52
 
    PRIME    AGING    BRAIN    IMMUNE   

Aaa06-005

The Amazing Benefits of Spermidine

Quote:In recent years, spermidine has emerged as a compound of interest in longevity and nutrition science, largely due to its role in autophagy, the bodys cellular cleanup system. However, spermidines importance extends well beyond general anti-aging mechanisms. In the brain, spermidine belongs to a class of molecules called polyamines, which play a critical role in regulating how brain cells communicate, adapt, and remain resilient over time. What are polyamines? Understanding spermidines neurological relevance begins with understanding what polyamines are and how they function in the nervous system.
Article: https://richardgoldberg.substack.com/p/the-amazing-benefits-of-spermidine
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Search Authors: Richard Goldberg,  Felton Nutrition, 
Search Words:
spermidine Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
autophagy Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
polyamines nervous system Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    AGING    BRAIN    NUTRITION   

Aaa06-006

Common household plant could hold key to fighting Alzheimers disease

Quote:Aloe vera, a rubbery green plant, may be best known for its skin-soothing qualities, but a study published in Current Pharmaceutical Analysis suggests that key chemicals within the plant could interact with enzymes involved in Alzheimers disease, hinting at a new approach to disrupting cognitive breakdown. A chemical messenger in the brain called acetylcholine, which helps nerve cells communicate, is reduced in Alzheimers patients, contributing to memory loss and cognitive decline, according to the study press release.
Comment: Computer simulations ("in silico") suggest that Beta sitosterol and Succinic acid emerge as potential drug candidates for Alzheimers disease. Incredible hype all over the internet, but no human or even lab rat tests. Succinic acid is a known chelating agent, and chelation does improve many conditions. Chelation rejuvinates the mitochondria, the energy powerouse of our cells. I have had Chelation, felt the amazing Rejuvination toward the end of the series.
Article: https://www.foxnews.com/health/common-household-plant-aloe-vera-could-hold-key-fighting-alzheimers-disease
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Search Words:
Beta sitosterol and Succinic acid Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Beta sitosterol Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Succinic acid Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
chelation Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
See Also:
  • https://www.sciencedaily.com/releases/2026/02/260206012213.htm
    •     PRIME    AGING    BRAIN    EXERCISE    SOC-MEDIA   

    Aaa06-007

    Scientists reveal the one practice that could prevent dementia as you age Ifrequent social contact raises neurological risk in older adunlts, study finds

    Quote:The study concluded that social frailty was associated with a higher risk of dementia, with socially frail individuals facing about a 47 increased risk compared to those in the non-frail group. In most socially frail people, the factors that were most strongly associated with this risk included low financial and family satisfaction, infrequent social contact and limited participation in social activity. ... The experts noted that mental and physical exercise are also crucial for keeping the brain young and sharp.
    Comment: HINT: Want social activity? You could email me... Javilk, same name/ID as the web site. Tell me what you think and what you are interested in.
    Article: https://www.foxnews.com/health/scientists-reveal-one-practice-could-prevent-dementia-you-age
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        PRIME    BRAIN    PSYCHOLOGY   

    Aab06-006

    Are SSRIs the most dangerous drugs?

    Quote:Side effects include blunting of emotions, loss of empathy, suicidal thoughs, etc. ... your emotions are there for a reason. You have to work through them, not put them on hold via drugs.
    Comment: Many mass shooters were on SSRI Serotonin Re-uptake Inhibitor drugs at the time of shooting. Serotonin is how the brain steers its thought processes. getting off them can be a problem, as Jordan Peterson found.
    Article: http://youtube.com/watch?v=IzDBvF8B43W
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        PRIME    BRAIN    METABOLISM   

    Mdb06-002

    Metabolic health specific functional connectivity signatures in the human brain

    Quote:Obesity and metabolic dysfunction are among the strongest risk factors for poor brain and mental health, yet the neural mechanisms linking metabolism, brain, and behaviour remains poorly understood. Here, we provide the first evidence for two distinct large-scale brain network configurations-one associated with metabolic health and another with obesity-identified using resting state fMRI data and metabolic phenotypes from a large community cohort
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345776v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345776v1.full-text
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    Search Authors: Kenneth S.L. Yuen Isabel Arend, 
        PRIME    AGING    BRAIN   

    Mgr06-004

    Associations of amyloid biomarkers with brain and cognitive changes from imaging, spinal fluid, and plasma

    Quote:DISCUSSION Using different measurement methods, amyloid was not consistently associated with volumetric or cognitive measures. Our findings also suggest that plasma markers may not be associated with cognitive and brain changes in the same manner as CSF and PET.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1.full-text
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    Search Authors: Jason Scully Mahsa Dadar Cassandra Morrison span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative, 
        PRIME    AGING    BRAIN   

    Mne06-008

    The prognostic value of blood-based p-tau217 levels on progression to clinical impairment

    Quote:Elevated p-tau217 associated with accelerated cognitive decline, both independent of, and synergistic with, greater A#946;-PET. These findings establish plasma p-tau217 as a robust prognostic marker in preclinical AD and support its value in future individualized risk prediction.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1.full-text
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    Search Authors: Rachel F. Buckley Diana L. Townsend Colin J. Birkenbihl Madison Cuppels Gillian T. Coughlan Mabel T. Seto Jane A. Brown Michael J. Properzi Merle C. Hnig Annie Li Aaron P. Schultz Jasmeer Chhatwal Hyun-Sik Yang Steven Arnold Pia Kiviskk Bryan D. James Sid OBryant Robert A. Rissman Melissa Petersen Jessica Z. K. Caldwell Tobey Betthauser Julie Elisabeth Oomens Maria Carrigan Brian Healy Jorge Garcia Condado Sterling Johnson Wai-Ying Wendy Yau Oliver Langford Michelle Farrell Rebecca E. Amariglio Dorene M. Rentz Kathryn V. Papp Timothy J. Hohman Michael Donohue Paul S. Aisen Keith A. Johnson Reisa A. Sperling, 
        BRAIN    BRAINWAVE    EYES   

    Mne06-014

    TMS-evoked phosphenes and oculomotor responses in visual-snow syndrome

    Quote:Here we developed an integrated protocol combining transcranial magnetic stimulation TMS-evoked phosphene mapping with high-resolution eye-tracking analysis. ... Post-TMS oculomotor responses showed markedly reduced saccadic velocity in the VSS patients versus controls. Thus, the combination of phosphene mapping and eye-tracking analysis provides an efficient tool for VSS assessment and paves the way to uncovering its underlying pathophysiology.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26344851v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26344851v1.full-text
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    Search Authors: Roman Akinshin Dinara Shankhoeva Dmitry Gribanov Artemiy Berkmush-Antipova Polina Meschanina Irina Tomilina Elizaveta Ostrovskaia Sergei Gostilovich Nikolay Syrov Anh-Huy Phan Mikhail Lebedev, 
        BRAIN   

    Mne06-018

    Simultaneous CBF and CMRGlu as imaging biomarkers for differential treatments in ICA/MCA steno-occlusive disease: a retrospective study

    Quote:CONCLUSIONS Despite similar perfusion profiles, the surgical group demonstrated lower glucose metabolism, suggesting that metabolic imaging may aid in identifying patients who could benefit from revascularization. ...
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345710v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345710v1.full-text
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    Search Authors: Bixiao Cui Yu Lu Min Wang Yi Shan Jie Ma Tao Wang Yan Ma Xiehui Jiang Jie Lu, 
        PRIME    AGING    BRAIN    COGNITION    PSYCHOLOGY   

    Mpy06-020

    Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC

    Quote:Introduction Lactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex dACC, a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. ... establishes a metabolic stress-testing paradigm for detecting latent neuroenergetic vulnerabilities, supporting fMRS utility for probing mitochondrial function in health and psychiatric disorders.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1.full-text
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    Search Authors: Edward Caddye Joel Patchitt Anouk Schrantee William T Clarke Itamar Ronen Alessandro Colasanti, 

      Updated weekly. 02/13/2026-07:20:23 PM
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