Research
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aging 9
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Scanned: 2653
Evaluated: 237
Selected: 57
 
    AGING   

Mge07-030

A network-based atlas of human skeletal muscle aging

Quote:. This prioritised network features over DE signatures, highlighting positive correlating edges to down-regulated genes during atrophy, genes up-regulated by Rapamycin and both positive and negative correlating insulin sensitivity features, along with gene hub status, best explained muscle ageing. Genome level modelling produced an independently validated transcriptomic age clock and found it to be invariant to muscle load status in people 50y, while we revealed novel interactions between gene length and age.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.15.26346348v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.15.26346348v1.full-text
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Search Authors: Tanner Stokes Changhyun Lim Muhammad Ali Jonathan C Mcleod Jack Gisby Katia Mariniello Hannah Crossland Jalil Sharif Colleen Deane Thomas C Moseley Nasim M Ismail Manoel E Lixandrao Claude-Henry Volmar Peter J McCormick Robert J Brogan James Whiteford Hamilton Roschel Stuart Phillips Iain J Gallagher Gregory Slabaugh Bethan E Phillips William E Kraus Philip J Atherton James P Chapple James A Timmons, 
    AGING   

Mgr06-002

Low-frequency oscillations in postural sway may have prognostic value for fall risk assessments in aging

Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345669v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345669v1.full-text
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Search Authors: M. Meyer Vega HN. Rizeq DJ. Goble PE. Gilbert N. Valadi N. Baweja HS. Baweja, 
    PRIME    AGING    BRAIN   

Mgr06-004

Associations of amyloid biomarkers with brain and cognitive changes from imaging, spinal fluid, and plasma

Quote:DISCUSSION Using different measurement methods, amyloid was not consistently associated with volumetric or cognitive measures. Our findings also suggest that plasma markers may not be associated with cognitive and brain changes in the same manner as CSF and PET.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1.full-text
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Search Authors: Jason Scully Mahsa Dadar Cassandra Morrison span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative, 
    PRIME    AGING   

Mne06-006

Predictive Value of Plasma P-tau217 and APOE Genotype for Preclinical Cognitive Decline in Alzheimers Disease

Quote:Conclusions Plasma P-tau217 levels and the presence APOE genotype can be used to estimate the interval before the onset of overt cognitive impairment and the diagnosis of AD. The findings here support the use of commercially available APOE genotyping and plasma P-tau217 to determine optimal timing for therapeutic intervention, particularly during the preclinical phase of the disease.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345774v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345774v1.full-text
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Search Authors: Yuexuan Xu Tamil Iniyan Gunasekaran Yian Gu Dolly Reyes-Dumeyer Angel Piriz Danurys Sanchez Diones Rivera Mejia Martin Medrano Rafael A. Lantigua Lawrence Honig Rachael Wilson Ramiro Eduardo Rea Reyes Jennifer J Manly Adam M. Brickman Corinne D. Engelman Sterling Johnson Sanjay Asthana David A. Bennett Melissa Petersen Sid OBryant Badri N. Vardarajan Richard Mayeux, 
    PRIME    AGING    BRAIN   

Mne06-008

The prognostic value of blood-based p-tau217 levels on progression to clinical impairment

Quote:Elevated p-tau217 associated with accelerated cognitive decline, both independent of, and synergistic with, greater A#946;-PET. These findings establish plasma p-tau217 as a robust prognostic marker in preclinical AD and support its value in future individualized risk prediction.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1.full-text
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Search Authors: Rachel F. Buckley Diana L. Townsend Colin J. Birkenbihl Madison Cuppels Gillian T. Coughlan Mabel T. Seto Jane A. Brown Michael J. Properzi Merle C. Hnig Annie Li Aaron P. Schultz Jasmeer Chhatwal Hyun-Sik Yang Steven Arnold Pia Kiviskk Bryan D. James Sid OBryant Robert A. Rissman Melissa Petersen Jessica Z. K. Caldwell Tobey Betthauser Julie Elisabeth Oomens Maria Carrigan Brian Healy Jorge Garcia Condado Sterling Johnson Wai-Ying Wendy Yau Oliver Langford Michelle Farrell Rebecca E. Amariglio Dorene M. Rentz Kathryn V. Papp Timothy J. Hohman Michael Donohue Paul S. Aisen Keith A. Johnson Reisa A. Sperling, 
    AGING    BRAIN    COGNITION   

Mne07-006

Plasma Proteomic Analysis of APOE 4 Homozygotes Identifies Preclinical Alzheimers Disease Alterations Potentially Treatable with Semaglutide

Quote:emaglutidea GLP-1 receptor agonistdemonstrated reversal effects on metabolic and synaptic pathway alterations in #1013;4 homozygotes at preclinical and clinical AD stages. Targeting metabolic and other pathways for therapeutic intervention in #1013;4/#1013;4 individuals by at least age 50 will likely be the most effective approach to decrease risk for AD in this special population.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v1.full-text
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Search Authors: Eric B Dammer Shiva Afshar Shijia Bian span classnlm-collab data-hwp-idcollab-1The Global Neurodegeneration Proteomics Consortium GNPC Allan I. Levey Juan Fortea Erik C.B. Johnson, 
    PRIME    AGING    COGNITION   

Mne07-038

Bilingualisms protective effects in Alzheimers disease: Mechanisms of resilience and resistance

Quote:DISCUSSION The protective effects of bilingual experience may engage both resilience and resistance to AD pathophysiology mechanisms. These results underscore the importance of capturing bilingualism in aging cohorts and the study of how lifestyle and sociocultural factors shape the biological expression of neurodegenerative disease.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.13.26345903v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.13.26345903v1.full-text
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Search Authors: Wenfu Bao Stephanie M. Grasso Isabel Sala M. Beln Snchez-Saudins Judit Selma-Gonzlez Javier Arranz Nuole Zhu Sara Rubio-Guerra igo Rodrguez-Baz Mara Carmona-Iragui Isabel Barroeta Ignacio Illn-Gala Juan Fortea Olivia Belbin Ldia Vaqu-Alczar Marco Calabria Eider M. Arenaza-Urquijo Alexandre Bejanin Daniel Alcolea Alberto Lle Miguel ngel Santos-Santos, 
    PRIME    AGING    COGNITION    HEART   

Mph06-002

A Novel Drug-Drug Interaction: Dihydropyridine Calcium Channel Blockers Amplify Gabapentin-Associated Dementia Risk

Quote:Conc: Conclusions We identified a novel drug-drug interaction whereby DHP CCB co-medication amplifies gabapentin-associated dementia risk, confirmed by time-varying analysis Rate Ratio1.65. The DHP-specific signal is biologically plausible given independent evidence that DHP CCBs may adversely affect cognition DREAM consortium, while the absence of interaction with verapamil aligns with its potential neuroprotective properties identified in drug repurposing studies. The F03-specific pattern suggests drug-induced cognitive impairment that may be reversible. These hypothesis-generating findings identify gabapentin-DHP CCB combinations as a target for cognitive safety monitoring and warrant confirmation with concurrent exposure measurement
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345763v1.full-text
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Search Authors: James W Green Suril Gohel Barbara Tafuto Luciana Mascarenhas Fonseca Michal Schnaider Beeri Sharon Sanz Simon James Scott Parrott Branimir Ljubic Michael Schulewski, 
    PRIME    AGING    BRAIN    COGNITION    PSYCHOLOGY   

Mpy06-020

Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC

Quote:Introduction Lactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex dACC, a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. ... establishes a metabolic stress-testing paradigm for detecting latent neuroenergetic vulnerabilities, supporting fMRS utility for probing mitochondrial function in health and psychiatric disorders.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1.full-text
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Search Authors: Edward Caddye Joel Patchitt Anouk Schrantee William T Clarke Itamar Ronen Alessandro Colasanti, 

  Updated weekly. 02/20/2026-11:39:18 PM
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