Research
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Scanned: 2653
Evaluated: 237
Selected: 57
 
    PRIME    AGING    BRAIN   

Mgr06-004

Associations of amyloid biomarkers with brain and cognitive changes from imaging, spinal fluid, and plasma

Quote:DISCUSSION Using different measurement methods, amyloid was not consistently associated with volumetric or cognitive measures. Our findings also suggest that plasma markers may not be associated with cognitive and brain changes in the same manner as CSF and PET.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345647v1.full-text
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Search Authors: Jason Scully Mahsa Dadar Cassandra Morrison span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative, 
    PRIME    AGING    BRAIN   

Mne06-008

The prognostic value of blood-based p-tau217 levels on progression to clinical impairment

Quote:Elevated p-tau217 associated with accelerated cognitive decline, both independent of, and synergistic with, greater A#946;-PET. These findings establish plasma p-tau217 as a robust prognostic marker in preclinical AD and support its value in future individualized risk prediction.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.06.26345770v1.full-text
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Search Authors: Rachel F. Buckley Diana L. Townsend Colin J. Birkenbihl Madison Cuppels Gillian T. Coughlan Mabel T. Seto Jane A. Brown Michael J. Properzi Merle C. Hnig Annie Li Aaron P. Schultz Jasmeer Chhatwal Hyun-Sik Yang Steven Arnold Pia Kiviskk Bryan D. James Sid OBryant Robert A. Rissman Melissa Petersen Jessica Z. K. Caldwell Tobey Betthauser Julie Elisabeth Oomens Maria Carrigan Brian Healy Jorge Garcia Condado Sterling Johnson Wai-Ying Wendy Yau Oliver Langford Michelle Farrell Rebecca E. Amariglio Dorene M. Rentz Kathryn V. Papp Timothy J. Hohman Michael Donohue Paul S. Aisen Keith A. Johnson Reisa A. Sperling, 
    BRAIN    BRAINWAVE    EYES   

Mne06-014

TMS-evoked phosphenes and oculomotor responses in visual-snow syndrome

Quote:Here we developed an integrated protocol combining transcranial magnetic stimulation TMS-evoked phosphene mapping with high-resolution eye-tracking analysis. ... Post-TMS oculomotor responses showed markedly reduced saccadic velocity in the VSS patients versus controls. Thus, the combination of phosphene mapping and eye-tracking analysis provides an efficient tool for VSS assessment and paves the way to uncovering its underlying pathophysiology.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26344851v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26344851v1.full-text
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Search Authors: Roman Akinshin Dinara Shankhoeva Dmitry Gribanov Artemiy Berkmush-Antipova Polina Meschanina Irina Tomilina Elizaveta Ostrovskaia Sergei Gostilovich Nikolay Syrov Anh-Huy Phan Mikhail Lebedev, 
    BRAIN   

Mne06-018

Simultaneous CBF and CMRGlu as imaging biomarkers for differential treatments in ICA/MCA steno-occlusive disease: a retrospective study

Quote:CONCLUSIONS Despite similar perfusion profiles, the surgical group demonstrated lower glucose metabolism, suggesting that metabolic imaging may aid in identifying patients who could benefit from revascularization. ...
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345710v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345710v1.full-text
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Search Authors: Bixiao Cui Yu Lu Min Wang Yi Shan Jie Ma Tao Wang Yan Ma Xiehui Jiang Jie Lu, 
    BRAIN    COGNITION   

Mne07-004

Quantitative Cerebrovascular Analysis for Improved Prediction of Post-Stroke Complications

Quote:Conclusions: These findings demonstrate that cerebrovascular structure?an often overlooked yet physiologically fundamental determinant of ischemic injury and reperfusion dynamics?provides significant predictive information that is not captured by standard clinical or visual imaging assessments. Automated vascular segmentation and collateral grading techniques enable rapid and objective integration of cerebrovascular metrics into prognostic models, offering a scalable tool for precision risk stratification, supporting earlier intervention, targeted monitoring, and improved post-EVT management.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.12.26346217v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.12.26346217v1.full-text
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Search Authors: Aditi Deshpande Jing Wang Laith Altaweel Seajin Yi Zelalem Bahiru Tahddeus Leiphart Pouya Tahsili-Fahadan Kaveh Laksari, 
    AGING    BRAIN    COGNITION   

Mne07-006

Plasma Proteomic Analysis of APOE 4 Homozygotes Identifies Preclinical Alzheimers Disease Alterations Potentially Treatable with Semaglutide

Quote:emaglutidea GLP-1 receptor agonistdemonstrated reversal effects on metabolic and synaptic pathway alterations in #1013;4 homozygotes at preclinical and clinical AD stages. Targeting metabolic and other pathways for therapeutic intervention in #1013;4/#1013;4 individuals by at least age 50 will likely be the most effective approach to decrease risk for AD in this special population.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v1.full-text
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Search Authors: Eric B Dammer Shiva Afshar Shijia Bian span classnlm-collab data-hwp-idcollab-1The Global Neurodegeneration Proteomics Consortium GNPC Allan I. Levey Juan Fortea Erik C.B. Johnson, 
    BRAIN   

Mne07-010

Long-Term Slowing of Progression in Huntingtons Disease with Pridopidine Treatment

Quote:Conclusions: In a two-year follow-up, continuous pridopidine treatment in participants remaining off-ADMs was associated with slower clinical progression relative to expected natural-history trajectories. Clinical Trials Identifier: NCT04556656
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.13.26345490v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.13.26345490v1.full-text
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Search Authors: Ralf Reilmann Andrew M Tan Anne E Rosser Kelly Chen Karen E. Anderson Sandra K Kostyk Andrew Feigin Randal Hand Michal Geva Michael R. Hayden, 
    BRAIN   

Mne07-022

Effective connectivity of the insula as measured by cortico-cortical evoked potentials

Quote:This study provides the highest-resolution effective connectivity mapping of the human insula from neurophysiological data. It complements well previous structural studies with additional dynamical and causal information, and definitely establishes the insula as a topologically organised hub connecting the different brain lobes
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.16.26344827v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.16.26344827v1.full-text
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Search Authors: Cristiana Pinheiro Maciej Jedynak Sofia Avalos-Alais Anthony Boyer Julien Bastin Philippe Kahane Olivier David span classnlm-collab data-hwp-idcollab-1F-TRACT Consortium, 
    BRAIN   

Mne07-040

The Role of Network Connectivity and Transcriptomic Vulnerability in Shaping Grey Matter Atrophy in Multiple Sclerosis

Abstract: https://www.medrxiv.org/content/10.64898/2026.02.13.26346243v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.13.26346243v1.full-text
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Search Authors: Mar Barrantes-Cepas Mario Tranfa David R. van Nederpelt Ismail Koubiyr Luigi Lorenzini Birgit Helmlinger Stefan Ropele Daniela Pinter Christian Enzinger Tomas Uher Manuela Vaneckova Joep Killestein Eva M.M. Strijbis Martijn D. Steenwijk Hugo Vrenken Frederik Barkhof Menno M. Schoonheim Giuseppe Pontillo, 
    PRIME    AGING    BRAIN    COGNITION    PSYCHOLOGY   

Mpy06-020

Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC

Quote:Introduction Lactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex dACC, a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. ... establishes a metabolic stress-testing paradigm for detecting latent neuroenergetic vulnerabilities, supporting fMRS utility for probing mitochondrial function in health and psychiatric disorders.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1.full-text
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Search Authors: Edward Caddye Joel Patchitt Anouk Schrantee William T Clarke Itamar Ronen Alessandro Colasanti, 
    BRAIN    GENETICS   

Mpy07-022

Shared and distinct phenotypic profiles among neurodevelopmental disorder genes

Quote:Gene Ontology enrichment analyses revealed distinct biological processes in each cluster, suggesting that coherent molecular mechanisms underlie the diYering NDD diagnostic profiles. Together these findings demonstrate that NDD genes fall into coherent clusters that consistently map onto characteristic phenotype profiles, providing a framework to inform future therapeutic strategies and support early prognostication for individuals with pathogenic variants in NDD genes.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.15.26346328v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.15.26346328v1.full-text
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Search Authors: Hermela Shimelis Matthew T. Oetjens Bobbi McGivern Zhancheng Zhang Janelle E. Stanton Ian McSalley Shiva Ganesan Brenda M. Finucane Ingo Helbig Christa L. Martin Scott M. Myers David H. Ledbetter, 

  Updated weekly. 02/20/2026-11:39:18 PM
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