| Research Topics: |
| INDEX |
| AI-chat 2 |
| MCS 1 |
| PRIME 26 |
| aging 9 |
| brain 11 |
| brainwave 2 |
| cancer 4 |
| climate 4 |
| cognition 7 |
| covid-19 2 |
| diabetes 2 |
| diagnostics 2 |
| economy 2 |
| eyes 2 |
| genetics 5 |
| heart 2 |
| immune 6 |
| language 1 |
| law 1 |
| lungs 1 |
| metabolism 1 |
| microbiome 1 |
| misc |
| nutrition 4 |
| politics 3 |
| pollution 3 |
| psychology 6 |
| sleep 4 |
| vaccine 1 |
| virus 2 |
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Scanned: 2653 Evaluated: 237 Selected: 57 |
| IMMUNE LUNGS VACCINE VIRUS | |||||||||||||||||||
Min06-010 | The interaction between influenza vaccination and nasal pneumococcal colonization alters airway T cell responses and alveolar macrophage activation | ||||||||||||||||||
| Quote: | Conclusions Our findings define how influenza vaccination and pneumococcal colonization converge in the human lung to reprogram AM-T cell crosstalk, enhancing local immune responses and protective immunity. By uncovering conserved macrophage modules and mechanisms that shape mucosal defense, this study provides a framework for designing next-generation respiratory vaccines and strategies to mitigate post-viral bacterial pneumonia. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345662v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345662v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Yuzhou Evelyn Tong Sergio Triana Daniela D. Russo Jesus Reine Jamie Rylance Simon P. Jochems Oluwasefunmi Akeju Pardis C. Sabeti Alex K. Shalek Daniela M. Ferreira Elena Mitsi, | ||||||||||||||||||
| IMMUNE PSYCHOLOGY | |||||||||||||||||||
Mpy06-004 | Genetic evidence for repurposing immunomodulatory drugs for major depressive disorder | ||||||||||||||||||
| Quote: | Conclusion We provide genetic evidence supporting the repurposing of immunomodulatory drugs for MDD, including compounds acting on novel therapeutic targets. Effects differ across depressive symptoms, suggesting that symptoms respond to different drug mechanisms. These findings highlight the importance of considering individual symptoms, rather than MDD as a unitary condition, when developing treatments with a broad spectrum of action or targeting specific symptom profiles. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.07.26345798v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.07.26345798v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Jehanita Jesuthasan Abigail R ter Kuile Jonathan Roiser Livia A Carvalho Alexandra Pitman Sandesh Chopade Chris Finan Amand Floriaan Schmidt Jean-Baptiste Pingault, | ||||||||||||||||||
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| MCS PRIME IMMUNE | |||||||||||||||||||
Mrh06-002 | NHAPL analysis of glycoRNA reveals sialic acid-containing glycosylated mRNA 3UTRs and enables sensitive SLE diagnostics | ||||||||||||||||||
| Quote: | we identify glycoRNA signatures highly specific to systemic lupus erythematosus SLE. In particular, glycoY5 and glycoU1 achieve near-complete discrimination between patients and healthy controls area under the curve AUC 1.00 and 0.9977, whereas conventional total RNA analysis fails to capture these differences, highlighting RNA glycosylation modification as a distinct regulatory layer. Its simplicity and flexibility make it well suited for clinical glycoRNA profiling and biomarker discovery. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345357v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345357v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Jie Gui Meng Zhang Ziwei Kan Xiaojuan He Meipei Gao Jian Han Qiongfang Wang Shengyao Zhang Junyi Hu Wenyi Qin Zi Bi Boyue Huang Zhongjun Wu Jianhua Ran, | ||||||||||||||||||
| PRIME IMMUNE | |||||||||||||||||||
Mrh06-004 | Pan-disease blood protein profiles of rheumatic autoimmune diseases | ||||||||||||||||||
| Quote: | Systemic autoimmune rheumatic diseases SARDs are a heterogeneous group of autoimmune conditions characterized by immune system dysregulation leading to chronic inflammation and tissue damage. The overlapping clinical manifestations make differential diagnosis challenging, ... This explorative cross-sectional study demonstrates the importance of a pan-disease approach to biomarker identification within and between the five SARDs. NPX boxplots from this study are available open-access through the Human Protein Atlas, facilitating further plasma-proteome research on autoimmune diseases. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345462v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345462v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Josefin Kenrick Charlotta Preger Mara Bueno lvez Alejandra Ulloa Gran Bergstrm Antonella Notarnicola Begum Horuluoglu Anna Smed-Srensen Anna Frnert Anna Norrby-Teglund Iva Gunnarsson Marie Wahren-Herlenius Marie Holmqvist Leonid Padyukov Karine Chemin Lina Marcela Diaz-Gallo Ingrid E. Lundberg Elisabet Svenungsson Vivianne Malmstrm Lars Klareskog Sofia Bergstrm Mathias Uhln Peter Nilsson Fredrik Edfors Elisa Pin, | ||||||||||||||||||
| IMMUNE | |||||||||||||||||||
Mrh07-022 | Longitudinal peripheral blood multi-omic profiling in seropositive individuals identifies immune endotypes and predictive models for future rheumatoid arthritis conversion | ||||||||||||||||||
| Quote: | Individuals who have serum elevations of anti-cyclic citrullinated protein anti-CCP antibodies are at risk for developing rheumatoid arthritis RA, yet immunologic factors that lead to a transition from pre- to clinical RA remain unclear. ... These findings define immune endotypes in pre-RA that could serve as targets for future preventive interventions and be used to stratify the risk of developing clinical RA in anti-CCP antibody-positive individuals. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.12.26346058v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.12.26346058v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Jun Inamo Aleksandra Bylinska Miles Smith Lauren Vanderlinden Christian Wright Tayte Stephens Marie L. Feser Christopher C. Striebich James R. ODell Jeffrey A. Sparks John M. Davis Jonathan Graf Maureen A. McMahon E. Blair Solow Lindsy J. Forbess Athan N. Tiliakos David A. Fox Maria I. Danila Diane Lewis Horowitz Jonathan Kay Judith A. James V. Michael Holers Kevin D. Deane Joel M. Guthridge Fan Zhang, | ||||||||||||||||||
| IMMUNE | |||||||||||||||||||
Mrh07-024 | Spatial transcriptomics reveals mechanism of autoimmunity driven by internalized autoantibodies | ||||||||||||||||||
| Quote: | Together, these findings establish autoantibody internalization as a shared pathogenic mechanism across diverse autoimmune diseases, providing a unifying framework for conditions driven by autoantibodies against intracellular antigens. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.14.26346329v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.14.26346329v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Iago Pinal-Fernandez Katherine Pak Maria Casal-Dominguez Sandra Munoz-Braceras Gustaf Wigerblad Stefania DellOrso Faiza Naz Shamima Islam Gustavo Gutierrez-Cruz Travis B Kinder S. Amara Ogbonnaya-Whittlesey Andreu Fernandez-Codina Margherita Giannini Benjamin Ellezam Gilles Laverny Valentine Gilbart Oceane Landon-Cardinal Marie Hudson Yves Troyanov Davide Randazzo Aster Kenea Ana Matas-Garcia Gloria Garrabou Iban Aldecoa Gabriela Ailen-Caballero Albert Gil-Vila Ernesto Trallero Margherita Milone Teerin Liewluck Elie Naddaf Gerard Espinosa Carmen Pilar Simeon-Aznar Alfredo Guillen-Del-Castillo Corinna Preusse Felix Kleefeld Nikolas Bublitz Werner Stenzel Alain Meyer Janet E Pope Albert Selva-OCallaghan Jose C Milisenda Andrew L Mammen, | ||||||||||||||||||
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02/20/2026-11:39:18 PM
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