GENETICS HEART
Mcr08-002	Genetic Prediction of Circulating Lipoproteina Levels in Diverse Populations
	Quote:	Background: Circulating lipoproteina Lpa levels are highly heritable and linked to atherosclerotic cardiovascular disease, yet clinical measurement rates remain low 1 in the United States. The high heritability of Lpa across populations makes genetic prediction an attractive approach for closing this testing gap, but existing polygenic scores transfer poorly across populations.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.20.26346738v2
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.20.26346738v2.full-text
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	Search Authors:	Michael Levin Margaret Sunitha Selvaraj Ha My Vy Renae Judy Michael C. Honigberg Archna Bajaj Girish C. Nadkarni Ron Do Pradeep Natarajan Joshua C. Denny Po-Ru Loh span classnlm-collab data-hwp-idcollab-1Penn Medicine Biobank,
PRIME GENETICS
Mge08-016	Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease Mechanisms
	Quote:	This insight facilitates clustering of complex health and disease phenotypes based on genetic architecture, and the dissection of polygenic traits reflecting the composite impact of many underlying processes. We show that leveraging pleiotropic information can enhance the selection of genetic instruments for causal inference approaches and improves prediction of drug trial success. This open-source resource is available at https://gpmap.opengwas.io, with functionality for user GWAS upload.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.19.26346618v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.19.26346618v1.full-text
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	Search Authors:	Andrew R. Elmore Aimee L. Hanson Genevieve M. Leyden James Johnson George Davey Smith Lavinia Paternoster Tom R Gaunt Gibran Hemani,
	See Also:	https://gpmap.opengwas.io
BRAIN GENETICS REPRODUCTION
Mpy08-010	Neonatal and Early Childhood Epigenetic Variation Linked to Social and Behavioral Outcomes in Very Preterm Children
	Quote:	DNAm patterns during early life, particularly the neonatal period, were associated with social-behavioral development in very preterm children. Findings in key genes such as TCF4 and CAMTA1 highlight potential epigenetic mechanisms linking early-life biology to later behavioral challenges.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.19.26346629v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.19.26346629v1.full-text
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	Search Authors:	Priyadarshni Patel Yijie Huang Marie Camerota Casey A. Cragin Brian S. Carter Jennifer Check Jennifer B. Helderman Julie A. Hofheimer Elisabeth C. McGowan Charles R. Neal T. Michael OShea Steven L. Pastyrnak Lynne M. Smith Carmen Marsit Barry Lester Todd M. Everson,
GENETICS IMMUNE
Mxa08-012	Defining and Modeling Human Interleukin-34 Deficiency
	Quote:	Interpretation A common human IL-34 loss-of-function variant creates a naturally occurring model of IL-34 deficiency that links microglial survival, CSF network signatures, and amyloid pathology in both mice and humans. These findings position IL-34/CSF1R signaling as a critical determinant of microglial resilience in AD and highlight IL-34-dependent pathways as potential targets for disease modification.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.21.26346696v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.21.26346696v1.full-text
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	Search Authors:	Francisco Hernandez-Rasco Rocio Ruiz Itziar De Rojas Raquel Puerta Fuentes Ana Maria Espinosa-Oliva Juan Garcia-Revilla Paula Bayon Alberto Rivera-Ramos Sebastian Jimenez Maria Saez Rocio M de Pablos Feiyang Zhao Claudia Olive Pilar Sanz Xavier Montalban Sergi Valero Amanda Cabo Maria Victoria Fernandez Jose Enrique Cavazos Sudha Seshadri Merce Boada MIchael Heneka Francisco Javier Vitorica Santos Maez Alfredo Ramirez Jose Luis Venero,

Updated weekly. 02/25/2026-08:05:42 PM
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Mcr08-002

Genetic Prediction of Circulating Lipoproteina Levels in Diverse Populations

Mge08-016

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease Mechanisms

Mpy08-010

Neonatal and Early Childhood Epigenetic Variation Linked to Social and Behavioral Outcomes in Very Preterm Children

Mxa08-012

Defining and Modeling Human Interleukin-34 Deficiency