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IMMUNE
VACCINE
VIRUS
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Min08-012 | Mapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccine |
| Quote: | Additional electron microscopy-based polyclonal epitope mapping studies confirmed that cross-reactive antibodies elicited by vaccination typically target epitopes on the side of HA. Together, our studies provide an immunological explanation of why the 2025-2026 influenza vaccine was partially effective against antigenically advance H3N2 subclade K viruses. Our data suggest that vaccine strains for subsequent seasons need to be carefully considered, since subclade K viruses have already started to acquire additional substitutions in HA antigenic sites targeted by cross-reactive antibodies.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.20.26346746v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.20.26346746v1.full-text |
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| Search Authors: |
Jiaojiao Liu Sydney Gang Caroline Kikawa Alesandra J. Rodriguez Shuk Hang Li Naiqing Ye Tachianna Griffiths Elizabeth M Drapeau Reilly K. Atkinson Andrea N. Loes Ronald G. Collman James A. Ferguson Julianna Han Andrew B. Ward Jesse D. Bloom Scott Hensley,
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IMMUNE
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Mrh08-002 | Deep learning-derived quantitative interstitial abnormalities in early rheumatoid arthritis and healthy controls: A multicenter, prospective cross-sectional study |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.20.26346723v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.20.26346723v1.full-text |
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Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho |
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Gregory C. McDermott Xiaosong Wang Natalie A. Davis Misti Paudel YIng Qi Emily Kowalski Grace Qian Liya S. Getachew Kevin T. Mueller Alene A. Saavedra Lauren A. OKeeffe Madeleine Beaule Ritu Gill Staci Gagne Suzanne Byrne Michael H. Cho Edwin K. Silverman Madison Negron Kathleen M.M. Vanni Caleb Bolden Tina Mahajan Erica Mulcaire-Jones Neda Kortam Paul F. Dellaripa Pierre-Antoine Juge Tracy J. Doyle Marcy B. Bolster Kevin D. Deane Dinesh Khanna Bryant R. England Raul San Jose Estepar George R. Washko Jeffrey A. Sparks,
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GENETICS
IMMUNE
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Mxa08-012 | Defining and Modeling Human Interleukin-34 Deficiency |
| Quote: | Interpretation A common human IL-34 loss-of-function variant creates a naturally occurring model of IL-34 deficiency that links microglial survival, CSF network signatures, and amyloid pathology in both mice and humans. These findings position IL-34/CSF1R signaling as a critical determinant of microglial resilience in AD and highlight IL-34-dependent pathways as potential targets for disease modification.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.21.26346696v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.21.26346696v1.full-text |
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Francisco Hernandez-Rasco Rocio Ruiz Itziar De Rojas Raquel Puerta Fuentes Ana Maria Espinosa-Oliva Juan Garcia-Revilla Paula Bayon Alberto Rivera-Ramos Sebastian Jimenez Maria Saez Rocio M de Pablos Feiyang Zhao Claudia Olive Pilar Sanz Xavier Montalban Sergi Valero Amanda Cabo Maria Victoria Fernandez Jose Enrique Cavazos Sudha Seshadri Merce Boada MIchael Heneka Francisco Javier Vitorica Santos Maez Alfredo Ramirez Jose Luis Venero,
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HEART
IMMUNE
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Mxb08-014 | Empiric Dietary Inflammatory Potential Score, Inflammatory Biomarkers, and Risk of Atrial Fibrillation: The Atherosclerosis Risk in Communities Study |
| Quote: | Conclusions: Pro-inflammatory dietary patterns are independently associated with higher AF risk in a middle-aged cohort. These findings would support incorporating dietary inflammatory load into AF risk stratification.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.23.26346939v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.23.26346939v1.full-text |
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Mohamed A. Mostafa Matthew J. Singleton Ghanshyam Shantha Prashant D Bhave Joseph Yeboah Elsayed Z. Soliman Takeki Suzuki,
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