IMMUNE VACCINE VIRUS
Min08-012	Mapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccine
	Quote:	Additional electron microscopy-based polyclonal epitope mapping studies confirmed that cross-reactive antibodies elicited by vaccination typically target epitopes on the side of HA. Together, our studies provide an immunological explanation of why the 2025-2026 influenza vaccine was partially effective against antigenically advance H3N2 subclade K viruses. Our data suggest that vaccine strains for subsequent seasons need to be carefully considered, since subclade K viruses have already started to acquire additional substitutions in HA antigenic sites targeted by cross-reactive antibodies.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.20.26346746v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.20.26346746v1.full-text
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	Search Authors:	Jiaojiao Liu Sydney Gang Caroline Kikawa Alesandra J. Rodriguez Shuk Hang Li Naiqing Ye Tachianna Griffiths Elizabeth M Drapeau Reilly K. Atkinson Andrea N. Loes Ronald G. Collman James A. Ferguson Julianna Han Andrew B. Ward Jesse D. Bloom Scott Hensley,

Updated weekly. 02/25/2026-08:05:42 PM
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