Research
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Scanned: 2656
Evaluated: 168
Selected: 44

 
    PRIME    AGING    DIABETES   

Aab09-004

Are Artificial Sweeteners Aging Your Brain?

Quote:The most pronounced effects appeared in adults under 60 and in people living with diabetes two groups that often rely on sugar substitutes such as aspartame, saccharine, and erythritol to manage calorie or glucose intake. Interestingly, tagatose was the only sweetener not linked to negative cognitive outcomes in this study.
Article: https://principia-scientific.com/are-artificial-sweeteners-aging-your-brain/
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    AGING    BRAIN    GENETICS    LUNGS   

Mge09-006

Genome-wide cross-trait analysis of vascular dementia and Alzheimers disease highlights novel loci and lung-brain axis

Quote:A multi-omics integrative analysis identified 619 genes. 241 genes were significantly differentially expressed in VD cells and 21 exhibited strong evidence of interaction with FDA-approved drugs. Collectively, our findings provide valuable insights into the potential underlying mechanisms of VD.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.27.26345967v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.27.26345967v1.full-text
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Search Authors: Guiyou Liu span classnlm-suffixSr. Shan Gao Shiyang Wu Fengzhen Liu Ping Zhu Yijie He Shuyuan Hu Ruibai Wang Jin Yang Lu Zhao Xuman Liu Zhifa Han Tao Wang Yan Zhang Kun Wang Yan Chen Keshen Li, 
    AGING    CANCER    GENDER   

Mge09-016

Evidence for sexual antagonism and antagonistic pleiotropy in the maintenance of late onset Alzheimers disease alleles

Quote:Multiple lines of evidence also suggest there is an inverse relationship between cancer and LOAD risk. The combined effect of sexual antagonism and antagonistic pleiotropy could explain the persistence of alleles that increase LOAD risk in post-reproductive females, if they also reduce cancer risk in males. This framework could be applied to other female-biased late-life conditions, and our results may be useful in informing polygenic risk scores or therapies where genotype-by-sex effects may result in undesired outcomes for one particular sex.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.26.26347171v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.26.26347171v1.full-text
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Search Authors: Edward H Morrow Jon Alexander Harper, 
    AGING    EXERCISE    NUTRITION   

Mgr09-022

Study protocol for FAXAge: A randomized, controlled clinical trial of fasting and exercise to slow aging in humans

Quote:The combined effect of exercise and TRF on aging biomarkers remains largely unexplored. In this 52-week four-armed, randomized, controlled trial clinicaltrials.gov: NCT07207044 240 healthy adults aged 65 and over will be allocated to four groups: combined cardio and strength training EXE, TRF, combined EXE and TRF, or control. Participants will undergo assessments at baseline, 3, 6, and 12 months, with follow-ups at 2, 5, and 10 years
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.28.26347327v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.28.26347327v1.full-text
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Search Authors: Emma B. Fals Emilie C. Springborg Adam B Berthelsen Jonas Nyeman-Nielsen Steen Larsen Morten Scheibye-Knudsen, 
    AGING    BRAIN    COGNITION   

Mgr09-024

Linking Modifiable Risk Factors to Vascular and Neurodegenerative Brain Changes

Quote:RESULTS Higher burden was associated with poorer global cognition, greater clinical severity, worse memory and fluency, and higher odds of WMHs, infarcts, and hippocampal atrophy. Structural equation models identified hippocampal atrophy as the primary mediator, with smaller effects for WMHs and infarcts.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.28.26347178v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.28.26347178v1.full-text
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Search Authors: Tamara Khudair Shima Raeesi Farooq Kamal Mahsa Dadar Cassandra morrison, 

  Javilk's Research Links for Week 09
Updated 03/07/2026-12:02:44 AM
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