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HEART
IMMUNE
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Mcr11-010 | Longitudinal immune transcriptomic signatures are associated with carotid intimamedia thickness over 18 years |
| Quote: | Conclusions PBMC transcriptional profiles are associated with subclinical vascular remodeling both cross-sectionally and over long-term follow-up, suggesting that systemic immune transcriptional states may contribute to vascular aging.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.12.26348144v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.12.26348144v1.full-text |
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| Search Authors: |
Anna DAntuono Giacomo Fantoni Elisabetta Giordano Valentina Spigoni Federica Fantuzzi Francesca Bagnaresi Gloria Cinquegrani Raffaella Aldigeri Francesco Balzam Cristina Branchi Mario Lauria Riccardo C. Bonadonna Luca Marchetti Alessandra Dei Cas,
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AGING
BRAIN
IMMUNE
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Mne11-014 | Single-cell multi-omic profiling allows the dissection of peripheral immune phenotypes in Alzheimers Disease progression |
| Quote: | Classical monocytes expanded in mild cognitive impairment and early AD dementia, acquiring a NF-kB/AP-1-mediated low-grade inflammation phenotype. Our findings link peripheral dysregulation in innate and adaptive immunity at cell frequency, transcriptional and epigenetic levels to the AD trajectory and provide insights into distinct phenotypes that define AD progression in contrast to healthy aging across cohorts.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.12.26348228v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.12.26348228v1.full-text |
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| Search Authors: |
Jannis B Spintge Karola Mai Caterina Carraro Martina van Uelft Francesco Elli Karoline Mauer Lisa Holsten Aleksej Frolov Janice Elangikal Emily Hinkley Jonas Schulte-Schrepping Mehrnoush H Shakiba Laura Lang Tarek Elmzzahi Doaa Hamada Sophie Mller Yuanfang Li Ioanna Gemnd Charlotte Krger Jacqueline Leidner Timo Zajac Jessica V Montgomery Celia Hartmann Bidour Hussein Maren Bttner Rainer Knoll Dina Hsson Rebekka Scholz Tobias Paschek Victoria Isakzai Nico Reusch Stefan Paulusch Anna Drews Michael Kraut Heidi Theis Marie Rthing Ulrike Strube Lukas Preis Daria Gref Eike J Spruth Maria Gemenetzi Klaus Fliessbach Niels Hansen Ayda Rostamzadeh Wenzel Glanz Enise I Incesoy Daniel Janowitz Sophia Stcklein Boris-Stephan Rauchmann Ingo Kilimann Doreen Goerss Sebastian Sodenkamp Marie Kronmller Sandra Roeske Anna Gamez Matthias Schmid Katharina Brger Julian Hellmann-Regen Christoph Laske Alfredo Ramirez Frederic Brosseron Jens Wiltfang Robert Perneczky Emrah Dzel Stefan Teipel Annika Spottke Gabor C Petzold Oliver Peters Josef Priller Susanne V Schmidt Michael Wagner Luca Kleineidam Frank Jessen Anja Schneider Lorenzo Bonaguro Elena De Domenico Anna C Aschenbrenner Matthias Becker Thomas Ulas Joachim L Schultze Marc D Beyer,
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IMMUNE
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Mrh11-002 | Costimulatory blockade depletes T peripheral helper, late-activated naive, and DN2 B cells in rheumatoid arthritis |
| Quote: | In conclusion, we have documented that abatacept affects the circulating immune cellular drivers of disease activity, Tph, late-aNAV and DN2. Therapeutic depletion of these pathologic lymphocyte subsets is associated with clinical benefits that can persist after therapy cessation. Hence, levels of these subsets may serve as surrogates for the overall burden of disease and potential response to abatacept therapy.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.14.26348386v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.14.26348386v1.full-text |
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Jasmine J. Shwetar Abhimanyu Amarnani William Rigby Sladjana Skopelia-Gardner Kelly V. Ruggles Gregg J. Silverman,
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IMMUNE
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Mrh11-004 | Single-cell RNA-seq reveals a persistent interferon signature in immune cells from Systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment |
| Quote: | Conclusions High polygenic risk in SLE is associated with persistent activation of IFN signaling pathways, indicating that antimalarial treatment alone is insufficient to fully suppress IFN activity, even during remission or low disease activity.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.12.26348018v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.12.26348018v1.full-text |
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Ahmed Sayadi Maija-Leena Eloranta Nina Oparina Marcus Wallgren Elisabeth Skoglund Martina Frodlund Christopher Sjwall Lars Rnnblom Dag Leonard,
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