| Research Topics: |
| INDEX |
| AI-chat 5 |
| PRIME 20 |
| aging 9 |
| brain 12 |
| brainwave 2 |
| cancer 8 |
| catastrophy 1 |
| cognition 8 |
| covid-19 3 |
| crime 1 |
| culture 3 |
| dental 3 |
| diabetes 3 |
| diagnostics 3 |
| economy 5 |
| exercise 1 |
| eyes 1 |
| genetics 6 |
| gut 2 |
| heart 5 |
| herbs 1 |
| immune 3 |
| kidneys 1 |
| language 2 |
| law 3 |
| lung 1 |
| metabolism 2 |
| microbiome 1 |
| nutrition 7 |
| pain 4 |
| physical 3 |
| politics 1 |
| pollution 1 |
| practice 1 |
| privacy 2 |
| psychology 13 |
| radiation 1 |
| religion 1 |
| rights 1 |
| sleep 2 |
| soc-media |
| stress 2 |
| unk |
| virus 1 |
| war-confl |
|
Scanned: 2629 Evaluated: 248 Selected: 73 |
| AGING DIABETES | ||||||||
Mge12-030 | Cross-omic dissection reveals locus-specific heterogeneity and antagonistic pleiotropy between Alzheimers disease and type 2 diabetes | |||||||
| Quote: | Five genes, GALNT10, HSD3B7, BCKDK, KAT8, and ACE, are supported across both regulatory layers, while numerous signals cluster within a regulatory hotspot at 16p11.2, supporting convergent transcriptional and epigenetic involvement, despite directional divergence. These results refine the AD-T2D relationship; rather than a simple shared-risk model, overlap reflects locus-specific heterogeneity and cross-omic convergence often showing opposing effects on AD versus T2D risk, consistent with antagonistic pleiotropy. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349030v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349030v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Emmanuel O Adewuyi Asa Auta Olayinka S Okoh Kaja Selmer Kristina Gervin Dale R Nyholt Gavin Pereira, | |||||||
| AGING COGNITION | ||||||||
Mge12-038 | Biological age acceleration measured by DunedinPACE associates most consistently with cognitive decline in elderly individuals | |||||||
| Quote: | Results: Among all tested DNAm clocks, DunedinPACE a third-generation clock showed the strongest and most consistent associations with cognitive performance. In addition, the fifth-generation SystemsAge framework also demonstrated robust associations with cross-sectional and longitudinal cognitive outcomes. In contrast, second-generation clocks GrimAge v2, PhenoAge showed occasional nominal associations, while first-generation clocks Horvath v1, Hannum and the causally-informed, fourth-generation clocks e. g. YingCausAge, YingDamAge showed no noteworthy signals. Likewise, telomere length estimated from DNAm was not strongly associated with cognitive performance in this dataset. Conclusions: Our findings highlight DunedinPACE as a particularly informative biomarker for various aspects of cognitive aging, while other DNAm aging measures showed no consistent associations. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349074v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349074v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Anna Marit Weissenburg Marit Philine Junge Jan Homann Valerija Dobricic Valentin Max Vetter Ulman Lindenberger Christina M Lill Ilja Demuth Sandra Duezel Lars Bertram, | |||||||
| AI-CHAT AGING HEART | ||||||||
Mgr12-022 | A deep-learning based biomarker of systemic cellular senescence burden to predict mortality and health outcomes | |||||||
| Quote: | Results The deep learning-based SASP Score was a strong, independent predictor of mortality risk and incident serious, chronic medical conditions e.g., dementia, COPD, myocardial infarction, stroke. In an independent cohort, multimodal exercise significantly changed the SASP Score trajectory over 18 months. Discussion Our findings support the potential of a deep learning-derived SASP Score as a biomarker for systemic cellular senescence burden. Our statistical approach can offer enhanced interpretability and cross-platform utility, providing a valuable tool for aging research and the evaluation of geroscience-guided interventions. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.20.26348913v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.20.26348913v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Shangshu Zhao Chia-Ling Kuo Eric J. Lenze Julie L. Wetherell Laura Haynes Perla El-Ahmad Richard Fortinsky George Kuchel Trevor Harris Breno Satler Diniz, | |||||||
| AGING BRAIN COGNITION HEART | ||||||||
Mne12-010 | Middle aged carotid plaque and cognitive functions in later life: a population-based study. Middle aged carotid plaque and cognitive functions in later life: a population-based study. | |||||||
| Quote: | Discussion: In this large cohort study, carotid plaque status at baseline was independently associated with in cognitive function decline, especially in non-verbal memory and executive functioning over 8-year follow-up period in the general population. Therefore, it may be important for earlier intervention on carotid plaque to preserve neurological health in middle-aged to older population. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349039v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349039v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Gisung Shin Ali Tanweer Siddiquee Min-Hee Lee June Christoph Kang Yoonho Hwang Seungku Lee Bongjo Kim Youngjin Kim Chol Shin Nanhee Kim Gisung Shin Ali Tanweer Siddiquee Min-Hee Lee June Christoph Kang Yoonho Hwang Seungku Lee Bongjo Kim Youngjin Kim Chol Shin Nanhee Kim, | |||||||
| AGING BRAIN COGNITION | ||||||||
Mne12-020 | The Case Against the S: Is Functional Neurological Disorders One Condition or Many? The Case Against the S: Is Functional Neurological Disorders One Condition or Many? | |||||||
| Quote: | Our results suggest that the symptom structure of FND is the result of a single pathophysiological process, either as a single entity, or a common pathway preceded by multiple causative processes where the common pathway is solely responsible for the phenotype of the condition. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.19.26348846v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.19.26348846v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | David D. G. Palmer Mark J. Edwards Jason Mattingley David D. G. Palmer Mark J. Edwards Jason Mattingley, | |||||||
| AGING | ||||||||
Mne12-032 | Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes | |||||||
| Quote: | Conclusions and Relevance: Genetic ancestry modifies the effect of APOE on AD endophenotypes. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349095v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349095v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Ana I Boeriu Tianjie Gu Brian Fulton-Howard Esteban M Lucero Jonathan A Shortt Christopher A Gignoux Farid J Rajabli Anthony J Griswold Kristine Yaffe Shea J Andrews Ana I Boeriu Tianjie Gu Brian Fulton-Howard Esteban M Lucero Jonathan A Shortt Christopher A Gignoux Farid J Rajabli Anthony J Griswold Kristine Yaffe Shea J Andrews, | |||||||
| AGING BRAIN | ||||||||
Mne12-034 | Multidomain determinants of perivascular spaces indicate early cerebrovascular vulnerability in individuals at risk of Alzheimers disease | |||||||
| Quote: | Determinants of PVS burden showed marked regional specificity. In the centrum semiovale, PVS burden was associated with age, male-sex and cardiometabolic factors. In contrast, hippocampal and midbrain PVS were more closely related to AD biomarker status and to psychological or sleep-related measures. Pronounced sex differences were observed, with men exhibiting higher PVS burden in centrum semiovale, while women showed higher PVS counts in the hippocampus, midbrain and basal ganglia. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349050v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.23.26349050v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Alba Fernandez-Bonet Gerard Temprano-Sagrera Patricia Genius Blanca Rodriguez-Fernandez Eugenia Domingo-Guell Jordi Huguet Mariateresa Buongiorno Gonzalo Sanchez Benavides Marta Cirach Mark Nieuwenhuijsen Marleen de Bruijne Tavia E Evans Natalia Vilor-Tejedor, | |||||||
| AGING BRAIN LANGUAGE | ||||||||
Mne12-040 | Structured retrieval closes the gap between low-cost and frontier clinical language models Structured retrieval closes the gap between low-cost and frontier clinical language models | |||||||
| Quote: | These findings indicate that retrieval architecture, rather than model scale alone, is a tractable lever for robust, equitable clinical LLM deployment. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.22.26349018v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.22.26349018v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Alon Gorenshtein Moran Sorka Mahmud Omar Keren Miron Adi Hatav Yiftach Barash Eyal Klang Shahar Shelly, | |||||||
| AGING COGNITION PSYCHOLOGY | ||||||||
Mpy12-036 | Invisible by Design: Three Mechanisms That Render Dementia Undetectable in Correctional Statistics Across Four High-Income Countries | |||||||
| Quote: | Interpretation Correctional mental health statistics across four high-income countries are structurally incapable of detecting dementia not through clinical ignorance but by design: systems built for younger populations that have not been updated as prison demographics have changed. Japans ageing female theft offender profile 39.4 aged 60 or older, 35.0 with low cognitive scores represents a potential sentinel population for undetected cognitive impairment. Targeted interventions cognitive screening at admission in the United States and Australia, introduction of a dementia classification category in Japan, and routine mental health data publication in the United Kingdom are feasible with existing infrastructure. As prison populations continue to age, the statistical invisibility of dementia constitutes an escalating failure of health surveillance with direct consequences for clinical care, sentencing, and human rights. | |||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.03.20.26348939v1 | |||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.03.20.26348939v1.full-text | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Hiroki Fukui, | |||||||
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Javilk's Research Links for Week 12 Updated 03/27/2026-11:59:04 PM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |