Research
Topics:
INDEX
AI-chat 7
PRIME 20
aging 5
brain 8
cancer 12
climate 3
cognition 5
covid-19 2
crime 2
dental 2
diabetes 6
disease 2
economy 3
eyes 1
gender 1
genetics 7
heart 6
kidneys 1
language 1
lungs 2
metabolism 4
microbiome 1
nutrition 7
obesity 1
pain 4
physical 1
politics 2
pollution 1
privacy 1
psychology 7
radiation 1
reproduction 4
rights 1
sleep 1
soc-media
stress 1
virus 2
war-confl
 
Scanned: 1426
Evaluated: 167
Selected: 66
 
    AGING    COGNITION    KIDNEYS   

Mge14-002

Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries

Quote: Alzheimer disease and kidney function share genetic components at specific loci rather than genome-wide, with mixed directional effects and horizontal pleiotropy explaining the absent global correlation despite strong local signals. At a subset of loci, we identified directional effects linking kidney genetic determinants to Alzheimer disease risk using cis-Mendelian randomization, supporting a complex kidneybrain genetic axis. Most overlap reflects horizontal pleiotropy, with limited loci showing vertical pleiotropy. APOE was the only shared locus across ancestries, underscoring ancestry-specific architectures with implications for risk prediction. The multi-scale approach used here also provides a methodological framework for dissecting complex disease relationships missed by traditional genome-wide analyses.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.04.26350158v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.04.26350158v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Diya Yang Yihe Yang Nicholas R. Ray Mengxuan Li Penelope Benchek Dana C. Crawford John F. OToole John R. Sedor Christiane Reitz Audrey Lynn Xiaofeng Zhu Jonathan L. Haines span classnlm-collab data-hwp-idcollab-1Alzheimers Disease Genetics Consortium (ADGC) William S. Bush, 
    AGING    BRAIN    COGNITION   

Mne14-006

Beyond Motor Fluctuations: Understanding the Clinical Correlates of OFF burden in Parkinsons Disease

Quote: Results: Clinical features explained more variance in OFF impact than OFF time (25. 9 vs 8. 1). OFF time was primarily linked to OFF state motor severity/freezing, with levodopa responsiveness important early. For OFF impact, predictability produced the largest increment in marginal R squared beyond the core motor model (pooled and Late). Within the core motor model, tremor was the largest contributor to OFF impact. Conclusions: Predictability is a prominent correlate of OFF impact
Comment: OFF is a symptoms flair when the body has used up available dopamine in Parkinsons.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.04.26350175v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.04.26350175v1.full-text
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Search Authors: David Ledingham Sahana Sathyanarayana Robyn Iredale Charlotte Bernadette Stewart Victoria Foster Debra Galley Mark R Baker Nicola Pavese, 
See Also:
  • https://www.healthline.com/health/parkinsons-disease/off-episodes-in-parkinsons-disease-faqs
    •     AGING    COGNITION    SLEEP   

    Mne14-010

    Obstructive Sleep Apnea is Associated with Peri-Lead Edema Following Deep Brain Stimulation for Parkinsons Disease

    Quote: Conclusions: OSA and perioperative hypoxemia are associated with symptomatic PLE following DBS, while RBD appears protective.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.05.26350193v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.05.26350193v1.full-text
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    Search Authors: Evgeniya Kornilov Uri Alkan Ella Harari Karam Azem Shlomo Fireman Eilat Kahana Johnathan Reiner Eilat Sapirstein Gal Sela Amir Glik Shai Fein Idit Tamir, 
    Search Words:
    REM Sleep Behavior Disorder (RBD) Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
        AGING    BRAIN    COGNITION   

    Mne14-020

    Tau pathological activity in plasma before the onset of symptomatic Alzheimer s disease

    Quote: VeraBIND Tau demonstrated 94.2 sensitivity and 96.1 specificity for predicting tau-PET positivity (AUC0.97). It outperformed plasma pTau217 in CU individuals (PPV85.9), regardless of the pTau217 threshold used (maximal PPV of 57.5 using the 0.256pg/mL pTau217 threshold)....

    These findings highlight the strong potential of VeraBIND Tau as a scalable and accurate screening tool to detect AD tau pathology in the general population. The assay may also help enrich clinical trials with tau-PET positive CU individuals, enhance clinical diagnostic workflows and support monitoring of tau-targeted therapies.

    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.03.26350110v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.03.26350110v1.full-text
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    Search Authors: Bernard J. Hanseeuw Lisa Quenon Jean-Louis Bayart Emilien Boyer Lise Colmant Yasmine Salman Thomas Gerard Lara Huyghe Vincent Malotaux Pascal Kienlen-Campard Flo Blondiaux Pirson Renaud Lhommel Laurence Dricot Adrian Ivanoiu Kavya Shamsundar Winnie Pak Joshua Soldo Khalid Iqbal, 
        AGING    BRAIN    PHYSICAL   

    Zza14-007

    Why Walking Backwards FIXES what Forward Walking Breaks

    Quote: Walking backwards revitalizes the brain
    Comment: This stimulates the brain in many ways, increasing coordination for many other actions as well.
    Article: http://youtube.com/watch?=vbUF1mry7i_k
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 

      Javilk's Research Links for Week 14
    Updated 04/11/2026-01:28:16 AM
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