AGING COGNITION KIDNEYS
Mge14-002	Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries
	Quote:	Alzheimer disease and kidney function share genetic components at specific loci rather than genome-wide, with mixed directional effects and horizontal pleiotropy explaining the absent global correlation despite strong local signals. At a subset of loci, we identified directional effects linking kidney genetic determinants to Alzheimer disease risk using cis-Mendelian randomization, supporting a complex kidneybrain genetic axis. Most overlap reflects horizontal pleiotropy, with limited loci showing vertical pleiotropy. APOE was the only shared locus across ancestries, underscoring ancestry-specific architectures with implications for risk prediction. The multi-scale approach used here also provides a methodological framework for dissecting complex disease relationships missed by traditional genome-wide analyses.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.04.04.26350158v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.04.04.26350158v1.full-text
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	Search Authors:	Diya Yang Yihe Yang Nicholas R. Ray Mengxuan Li Penelope Benchek Dana C. Crawford John F. OToole John R. Sedor Christiane Reitz Audrey Lynn Xiaofeng Zhu Jonathan L. Haines span classnlm-collab data-hwp-idcollab-1Alzheimers Disease Genetics Consortium (ADGC) William S. Bush,

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Updated 04/11/2026-01:28:16 AM
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Mge14-002

Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries