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Scanned: 1397
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Selected: 78

 
    LUNGS    MICROBIOME   

Mbr17-016

The Association Between Oral Microbiota and Chronic Obstructive Pulmonary Disease: An Integrated Study of Genetic Causal Inference and Bioinformatics Analysis

Quote: Results Forward MR identified 48 taxa associated with COPD, primarily from genera such as Fusobacterium, Prevotella, and Streptococcus. Reverse MR detected 79 taxa affected by COPD, mainly involving Campylobacter, Rothia, and Streptococcus. Through the PPI network, machine learning screening, and multi-omics analysis validation, MPDZ emerged as a key hub gene, upregulated in Ciliated cells and linked to immune dysregulation. Molecular docking revealed six candidate drugs with strong binding affinity to MPDZ.
Abstract: https://www.medrxiv.org/content/10.64898/2025.12.01.25341371v3
Full Text: https://www.medrxiv.org/content/10.64898/2025.12.01.25341371v3.full-text
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Search Authors: Xiao-Jie An Zi-Feng Wei Yi-Ting Huang Jia-Pei Wuzhang Xin-Xin Zhang Hao-Yu Li Run-Ze Liu, 
    LUNGS   

Mbr17-020

Pleuroparenchymal fibroelastosis in monogenic DGUOK-associated mitochondriopathy

Quote: Conclusion PPFE in children and young adults is associated with DGUOK-related mitochondriopathy. For the first time, we demonstrate Aberrant Basaloid cells in pediatric fibrotic lung tissue. Since pulmonary involvement may be underrecognized or misinterpreted and the clinical presentation may not always be typical of a mitochondriopathy, we recommend genetic testing in all patients with PPFE of unknown origin.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.08.26349275v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.08.26349275v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Sandra von Hardenberg Pia Maier Leonard Christian Anibh Martin Das Lavinia Neubert Jannik Ruwisch Katrin Peters Dirk Schramm Matthias Griese Britta Skawran Marlies Eilers Danny Jonigk Norman Junge Aiden Haghikia Tobias Hegelmaier Winfried Hofmann Benjamin Seeliger Diane Miriam Renz Amelie Stalke Lara Hartmayer Alexander Duscha Martin Schulze Nataliya DiDonato Holger Prokisch Bernd Auber Lars Knudsen Jonas C Schupp Nicolaus Schwerk, 

  Javilk's Research Links for Week 17
Updated 05/02/2026-01:34:02 AM
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