LUNGS MICROBIOME
Mbr17-016	The Association Between Oral Microbiota and Chronic Obstructive Pulmonary Disease: An Integrated Study of Genetic Causal Inference and Bioinformatics Analysis
	Quote:	Results Forward MR identified 48 taxa associated with COPD, primarily from genera such as Fusobacterium, Prevotella, and Streptococcus. Reverse MR detected 79 taxa affected by COPD, mainly involving Campylobacter, Rothia, and Streptococcus. Through the PPI network, machine learning screening, and multi-omics analysis validation, MPDZ emerged as a key hub gene, upregulated in Ciliated cells and linked to immune dysregulation. Molecular docking revealed six candidate drugs with strong binding affinity to MPDZ.
	Abstract:	https://www.medrxiv.org/content/10.64898/2025.12.01.25341371v3
	Full Text:	https://www.medrxiv.org/content/10.64898/2025.12.01.25341371v3.full-text
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	Search Authors:	Xiao-Jie An Zi-Feng Wei Yi-Ting Huang Jia-Pei Wuzhang Xin-Xin Zhang Hao-Yu Li Run-Ze Liu,
HEART MICROBIOME
Mcr17-012	Hypertension Associated Characteristics of Gut Archaea and Their Interaction Network with Bacteria
	Quote:	Conclusions This study provides the first comprehensive characterization of gut archaeal dysbiosis in hypertension. Reduced methanogenic archaea and remodeled cross-domain networks are hallmarks of hypertension. Gut archaeal signatures serve as promising noninvasive biomarkers.
	Abstract:	https://www.medrxiv.org/content/10.1101/2024.04.25.24305417v2
	Full Text:	https://www.medrxiv.org/content/10.1101/2024.04.25.24305417v2.full-text
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	Search Authors:	Wen Yuan Yihang Chen Jian Meng Luyun Fan Hongjie Chi Jing Li Xun Zhang Lin Feng Pixiong Su Jiuchang Zhong Tianhui Li Baicun Li Xiaoyan Liu,
DENTAL MICROBIOME NUTRITION
Mde17-002	Diet Explains Significant Variance in Oral Microbial Community Structure
	Quote:	Healthier dietary profiles, including higher health-associated dietary index scores and greater vegetable and fruit intake, were associated with taxa commonly linked to oral health (e.g., Neisseria, Cardiobacterium and Lautropia). In contrast, added sugars, alcoholic drinks, cured meat, potatoes, dairy products, and higher dietary inflammatory index scores showed opposite association patterns. Mediation analyses suggested that coordinated microbial groups may partly link dietary exposures with oral disease outcomes, particularly for vegetables and added sugars. Additionally, three population-level dietary patterns were identified, among which the plant-rich pattern was associated with more favorable oral health and microbial profiles enriched in nitrate-reducing commensals, including Neisseria and Haemophilus
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.04.24.26351661v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.04.24.26351661v1.full-text
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	Search Authors:	Yu Xie Mengning Bi Wen Gu Yuan Li Andrea Roccuzzo Bob T. Rosier Maurizio S. Tonetti,
BRAIN DIABETES GUT MICROBIOME NUTRITION PSYCHOLOGY
Sda171-014	Harvard Scientists Link Gut Bacteria to Depression Through Hidden Inflammation Trigger Diabetes Diet and Weight Loss Diseases and Conditions
	Quote:	A gut bacterium may be quietly fueling depression through an unexpected chemical twist. Researchers found that when Morganella morganii interacts with a common pollutant, it produces a molecule that triggers inflammationsomething strongly linked to depression. This finding helps explain how gut microbes can influence brain health at a molecular ...
	Article:	https://www.sciencedaily.com/releases/2026/04/260425091216.htm
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Javilk's Research Links for Week 17
Updated 05/02/2026-01:34:02 AM
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Mbr17-016

The Association Between Oral Microbiota and Chronic Obstructive Pulmonary Disease: An Integrated Study of Genetic Causal Inference and Bioinformatics Analysis

Mcr17-012

Hypertension Associated Characteristics of Gut Archaea and Their Interaction Network with Bacteria

Mde17-002

Diet Explains Significant Variance in Oral Microbial Community Structure

Sda171-014

Harvard Scientists Link Gut Bacteria to Depression Through Hidden Inflammation Trigger Diabetes Diet and Weight Loss Diseases and Conditions