DIABETES OBESITY
Mdb17-008	A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults: 2026 Update
	Quote:	. Semaglutide reduced major adverse cardiovascular events and all-cause mortality. In dedicated complication-specific trials, semaglutide and tirzepatide showed benefit on heart-failure-related outcomes; tirzepatide was associated with improved obstructive sleep apnoea syndrome and semaglutide with knee osteoarthritis pain remission. Tirzepatide and semaglutide were associated with improvements in metabolic dysfunction-associated steatohepatitis remission, and semaglutide with improvement in liver fibrosis. No OMMs were associated with an increased risk of serious adverse events. These updated results reinforce the need to individualize OMMs selection according to weight-loss efficacy, complication profile and safety.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.04.19.26351196v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.04.19.26351196v1.full-text
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	Search Authors:	Andreea Ciudin Jennifer L. Baker Andrej Belani Luca Busetto Dror Dicker ubomra Fbryov Gema Frhbeck Gijs H. Goossens Jason Gordon Matteo Monami Paolo Sbraccia Borja Martinez-Tellez Volkan Yumuk Barbara McGowan,
COGNITION OBESITY PSYCHOLOGY
Mdb17-012	Longitudinal Central Adiposity Accumulation is Associated with Cortical Alteration and Impaired Cognitive Function in Adolescents
	Quote:	The study reveals that central fat (BRI/WHtR) is closely linked to neurocognitive risks, and longitudinal fat accumulationrather than baseline adipositydrives cortical alteration. Notably, fat reduction activated adaptive neural change in obese adolescents, underscoring the importance of weigh regulation during neurodevelopment.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.04.22.26351453v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.04.22.26351453v1.full-text
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	Search Authors:	Lingxuan Zhang Bowen Qiu Zhifan Chen Xinyi Xu Ruoke Zhao Yiwei Chen Chenglin Ning Ruike Chen Mingyang Li Dan Wang Junfen Fu Dan Wu,
NUTRITION OBESITY
Mnu17-012	Meal Timing Patterns and Associations with Fat Mass in Adolescents
	Quote:	Conclusions Distinct multidimensional meal timing patterns emerged in early adolescence, with the delayed start, condensed eating period pattern potentially associated with higher adiposity.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.04.22.26351498v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.04.22.26351498v1.full-text
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	Search Authors:	Jessica E. Decker Knashawn H. Morales Pin-Wei Chen Lindsay Master Misol Kwon Erica C. Jansen Babette S. Zemel Jonathan A. Mitchell,

Javilk's Research Links for Week 17
Updated 05/02/2026-01:34:02 AM
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Mdb17-008

A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults: 2026 Update

Mdb17-012

Longitudinal Central Adiposity Accumulation is Associated with Cortical Alteration and Impaired Cognitive Function in Adolescents

Mnu17-012

Meal Timing Patterns and Associations with Fat Mass in Adolescents