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GENETICS
PSYCHOLOGY
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Mge18-024 | Directional genetic relationships between obsessive-compulsive disorder and bipolar disorder and schizophrenia |
| Quote: |
Conclusions Together, these findings indicate that genetic liability to
OCD can represent an early component of transdiagnostic psychiatric
risk, with implications for understanding and potentially predicting
the emergence of broader psychopathology across the life course.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.05.01.26352245v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.05.01.26352245v1.full-text |
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| Search Authors: |
Maria Niarchou Marina Natividad Avila Behrang Mahjani Joseph D. Buxbaum Niamh Mullins Dorothy E. Grice,
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GENETICS
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Mge18-032 | Combinatorial effects of gene dosage, polygenic background and environment on complex traits |
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These results indicate that genetic effects follow additive patterns in
aggregate, while context-dependent deviations are widespread for
specific loci.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.04.30.26352063v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.04.30.26352063v1.full-text |
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Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho |
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Molly F. Sacks Marieke Klein Tim B. Bigdeli Mart Kals Matthew T. Oetjens Florian Bnitire Jacquelyn Johnson Adam Maihofer Margit Nukas Michael Francis Bryan Gorman Iskander Said Giulio Genovese Georgios Voloudakis Kyriacos Markianos Murray Stein Joel Gelernter David H. Ledbetter Caroline M. Nievergelt Christa Lese Martin Vincent-Raphal Bourque Omar Shanta Jeffrey R. MacDonald Bhooma Thiruvahindrapuram Mamad Ahangari Anjali Srinivasan James Guevara Jessica H. Hall Josephine E. Haddon Claudia Vingerhoets David Linden Mieke M. van Haelst Marianne B.M. van den Bree Carrie E. Bearden Raquel E. Gur T. Blaine Crowley Daniel E. McGinn Beverly S. Emanuel Elaine H. Zackai Ann Swillen Thrse van Amelsvoort Jacob Vorstman Anne S. Bassett Donna M. McDonald-McGinn Panos Roussos Mihaela Aslan Philip D. Harvey span classnlm-collab data-hwp-idcollab-1Million Veteran Program span classnlm-collab data-hwp-idcollab-2Estonian Biobank Research Team span classnlm-collab data-hwp-idcollab-3Genes to Mental Health Network Sbastien Jacquemont Saiju Pyarajan Kelli Lehto Peter M. Visscher Jonathan Sebat,
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GENETICS
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Mge18-034 | Genome-wide detection and clinical prioritization of tandem repeat outliers using long-read sequencing |
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Background Tandem repeat expansions (TREs) cause over 60 known
neurological, neuromuscular, and developmental disorders. Detecting
these expansions genome-wide is challenging due to their size, sequence
complexity (including interruptions), and population variation.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.04.30.26352103v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.04.30.26352103v1.full-text |
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Sophia B. Gibson Nikhita Damaraju J. Gus Gustafson Elsa V. Balton Sirisak Chanprasert Ian A. Glass Martha Horike-Pyne Runjun D. Kumar Kathleen A. Leppig Chris Lundberg Jane Ranchalis Elisabeth A. Rosenthal Andrew K. Solomon Andrew B. Stergachis Mark Wener span classnlm-collab data-hwp-idcollab-1Undiagnosed Diseases Network Gail P. Jarvik Elizabeth E Blue Katrina M. Dipple Harriet Dashnow Lea M. Starita Danny E. Miller,
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