AGING CANCER DIABETES HEART METABOLISM
Aab20-006	What Are Sirtuins and How Do They Affect Aging and Longevity?
	Quote:	Sirtuins are NAD -dependent enzymes that regulate metabolism, oxidative stress, mitochondrial function, and genomic stability to influence aging and healthspan. Their tissue-specific activities have made them promising but complex therapeutic targets for metabolic, cardiovascular, neurodegenerative, and age-related diseases.... Sirtuins facilitate adaptive metabolic responses during periods of fasting, caloric restriction, and exercise. For example, SIRT1 acts as an autophagy modulator through the deacetylation of major transcription factors like peroxisome-activated receptor coactivator 1-#945; (PGC-1#945;) and forkhead box O3 (FoxO3) proteins, thereby enhancing fatty acid oxidation and glucose production in the liver. In skeletal muscles, SIRT1 has been associated with mitochondrial biogenesis and improved insulin sensitivity to support systemic metabolic health. Skeletal-muscle sirtuins also regulate glucose uptake, fatty acid oxidation, mitochondrial dynamics, autophagy, myogenesis, fiber-type switching, regeneration, and exercise adaptation, although these effects remain isoform- and context-dependent.
	Article:	https://www.news-medical.net/health/What-Are-Sirtuins-and-How-Do-They-Affect-Aging-and-Longevity.aspx
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HEART
Mre20-026	CUOREMA: Immersive Bio Behavioral Feedback and Digital Interventions for Cardiac Rehabilitation - Exploratory Analysis
	Quote:	Engagement clusters were not associated with demographic factors; instead, psychological themes of patients personal goals suggested that intrinsic motivation characterized sustained users, whereas extrinsic motivation predominated among early dropouts. User experience was rated positively, and validated questionnaire scores showed no deterioration over time. One center demonstrated a statistically significant improvement in 6-minute walking test performance, though the study was not powered to detect clinical outcomes and selective dropout cannot be ruled out. These findings highlight engagement variability as a central challenge in digital cardiac rehabilitation and suggest that tailoring interventions to individual motivational profiles may improve long-term adherence.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.05.15.26353188v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.05.15.26353188v1.full-text
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	Search Authors:	Radoslava vihrov Davide Marzorati Tania Odello Giuliana Monachino Tanya Staletti Rob Tieben Ren Luigies Nicolette Bodewes Werner Rutten Glynn Barrett Amber Bhogal Tom Wilkinson Athina Tzovara Francesca Dalia Faraci,
BRAIN EXERCISE HEART
Sda201-014	The Real Reason Exercise Makes You Stronger Isnt What You Think
	Quote:	Exercise may be training your brain just as much as your body. Researchers discovered that certain brain cells stay highly active even after a workout ends, and those lingering signals appear to help the body build endurance over time. In experiments with mice, blocking these brain cells prevented improvements in stamina, even when the animals still exercised ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260515233346.htm
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HEART NUTRITION
Sda201-038	Scientists Uncover Surprising Health Benefits of Watermelon
	Quote:	Studies suggest watermelon could be a hidden powerhouse for better health. Researchers found that people who eat watermelon tend to have higher-quality diets packed with more vitamins, fiber, and antioxidants while consuming less added sugar and saturated fat. Another study showed watermelon juice may help protect blood vessel function and support heart ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260517030515.htm
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EXERCISE HEART
Sda204-036	This 800-year-old Chinese Exercise Helps Lower Blood Pressure Naturally
	Article:	https://www.sciencedaily.com/releases/2026/05/260510234724.htm
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CANCER HEART LUNGS POLLUTION
Sda204-118	Your Fireplace May Be Doing More Harm Than You Think
	Quote:	Home fireplaces and wood stoves are quietly driving a large share of winter air pollution, even though only a small number of households rely on wood heat. Researchers found that wood smoke accounts for over one-fifth of Americans winter exposure to dangerous fine particles linked to heart disease and early death.
	Comment:	Then there is the carbon Moxide 10 - 20ppm, way below a UL approved detectors alert level, can cause flu-like symptoms and harm the immune system. UL will not approve low level detectors becaue fire departments do not want hundreds of calls during routine temperature inversions. Yet firemen have to don breathing equipment at 50pp.
	Article:	https://www.sciencedaily.com/releases/2026/01/260126075839.htm
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Javilk's Research Links for Week 20
Updated 05/22/2026-09:49:18 PM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.

Aab20-006

What Are Sirtuins and How Do They Affect Aging and Longevity?

Mre20-026

CUOREMA: Immersive Bio Behavioral Feedback and Digital Interventions for Cardiac Rehabilitation - Exploratory Analysis

Sda201-014

The Real Reason Exercise Makes You Stronger Isnt What You Think

Sda201-038

Scientists Uncover Surprising Health Benefits of Watermelon

Sda204-036

This 800-year-old Chinese Exercise Helps Lower Blood Pressure Naturally

Sda204-118

Your Fireplace May Be Doing More Harm Than You Think