| Research Topics: |
| INDEX |
| AI-chat 4 |
| PRIME 24 |
| aging 8 |
| brain 6 |
| cancer 8 |
| cognition 5 |
| culture 1 |
| diabetes 2 |
| diagnostics 3 |
| economy 1 |
| genetics 2 |
| gut 1 |
| heart 5 |
| immune 2 |
| microbiome 1 |
| misc 1 |
| nutrition 6 |
| obesity 1 |
| pain 3 |
| politics 2 |
| pollution 2 |
| population 1 |
| practice 1 |
| privacy 1 |
| psychology 2 |
| religion 1 |
| reproduction 2 |
| sleep 2 |
| vaccine 3 |
|
Scanned: 2601 Evaluated: 105 Selected: 42 |
| PRIME AGING BRAIN COGNITION | |||||||||||||||||||
Aac23-000 | Is Coconut Oil A Possible Cure for Alzheimers? | ||||||||||||||||||
| Quote: |
Since 2003, approximately 99 percent of Alzheimers drug trials have
failed to live up to expectations (Cummings, Alzheimers Research
Therapy, 2019); one analysis pegs the pipeline failure rate at 99.6
percent (Life Sciences, 2022)....
HHS Secretary Robert F. Kennedy Jr. has described the amyloid pipeline as built on "utter corruption" (Science, May 14, 2025), and in January 2026 he appointed a new Federal Alzheimers Advisory Council chair and ten new members tasked with broadening the agenda beyond amyloid.... In 2005, Brown University researchers led by Dr. Suzanne de la Monte examined the brains of Alzheimers patients with no history of diabetes. They found insulin resistance and insulin deficiency in every brain, and coined the term Type 3 diabetes (de la Monte Wands, J. Diabetes Sci. Tech., 2008). The dysfunction begins 10 to 20 years before symptoms (de la Monte, 2014). ... | ||||||||||||||||||
| Article: | https://principia-scientific.com/is-coconut-oil-a-possible-cure-for-alzheimers/ | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| PRIME AGING PSYCHOLOGY | |||||||||||||||||||
Mep23-022 | Cultural engagement and mental disorders: A prospective negative control analysis of the English Longitudinal Study of Ageing with linked Hospital Episode Statistics | ||||||||||||||||||
| Quote: | These findings provide triangulated statistical data to suggest that cultural engagement is associated with reduced risk of several clinically recorded mental disorders and support further testing of cultural engagement as a population mental health strategy. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.06.05.26354991v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.06.05.26354991v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Pei Qin Andrew Steptoe Daisy Fancourt, | ||||||||||||||||||
| PRIME AGING GENETICS | |||||||||||||||||||
Mge23-024 | TACR3 variant confers resilience to aging and Alzheimers disease | ||||||||||||||||||
| Quote: | Conclusions rs2765 WT confers resilience to age- and AD-related cognitive decline through RBMX-dependent regulation of NK3-R expression, with effects of remarkable size cascading from memory to systemic aging. rs2765 genotyping could stratify individuals for NK3-R modulator therapy (e.g., fezolinetant or senktides) and identify those maintaining function despite pathological burden, complementing APOE-based risk assessment in precision geromedicine. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.06.06.26355071v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.06.06.26355071v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Nicolas Ruffini Florian Udo Fischer Robert Subirana Slotos Julia Goschke Leon Scholz Kristel Knaepen Stefan Httelmaier Helen Morrison Theresa Steffan Ann-Sophie Pabst Jennifer Winter Bernhard Baier Andreas Mierau Harald Binder Alexander Drzezga Stefan Teipel Andreas Fellgiebel Kristina Endres Oliver Tscher span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative, | ||||||||||||||||||
| AGING BRAIN COGNITION | |||||||||||||||||||
Mge23-026 | Multi-ancestry analysis of POLG variants in Parkinsons disease | ||||||||||||||||||
| Quote: | Conclusions POLG variants are overall rare in PD. The identification of rare pathogenic variants among PD cases suggests that POLG-related mitochondrial dysfunction may contribute to PD in isolated instances, particularly under recessive inheritance. Our findings support a role for POLG variants in select cases and underscore the need for larger-scale sequencing and functional studies. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.06.07.26354811v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.06.07.26354811v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Yi Wen Tay Inas Elsayed Dennis Yeow Mikayla James Pin-Jui Kung Laurel Screven Allison A. Dilliott Roy N. Alcalay Zih-Hua Fang Ai Huey Tan span classnlm-collab data-hwp-idcollab-1the Global Parkinsons Genetics Program (GP2) Carolyn M Sue Lara M Lange Maria Teresa Perian, | ||||||||||||||||||
| Search Words: |
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| PRIME AGING COGNITION | |||||||||||||||||||
Sda233-007 | Popular Joint Supplement Glucosamine Linked to Faster Alzheimers Progression | ||||||||||||||||||
| Quote: | A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimers disease. Researchers found a 25 higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why. | ||||||||||||||||||
| Article: | /releases/2026/06/260610003044.htm https://www.sciencedaily.com/releases/2026/06/260610003044.htm | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| PRIME AGING BRAIN COGNITION | |||||||||||||||||||
Sda233-013 | Scientists Found a New Alzheimers Trigger and a Drug That Stops It | ||||||||||||||||||
| Quote: |
GRK2 exists in two forms inside cells. One form functions normally,
while the other becomes inactive through cellular processes. The
researchers found that the inactive version accumulates in large
amounts in the brains of people with dementia. Similar patterns were
also observed in mice that develop Alzheimers-like symptoms....
"The GRK2 aggregates block the pores of the mitochondria, reducing the amount of energy they can supply and leading to a situation of stress inside the cells," Quitterer explains. The team also found that inactive GRK2 appears to increase the production of amyloid beta, a protein fragment widely associated with Alzheimers disease. | ||||||||||||||||||
| Article: | /releases/2026/06/260608035959.htm /releases/2026/06/260608035959.htmhttps://www.sciencedaily.com/releases/2026/06/260608035959.htm | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| AGING COGNITION | |||||||||||||||||||
Sda233-040 | Dementia Risk Linked to Nitrate in Drinking Water, Study Finds | ||||||||||||||||||
| Quote: |
A major long-term study of more than 54,000 adults found that where
nitrate comes from may matter far more than how much you consume.
People who got more nitrate from vegetables"roughly the amount in a cup
of baby spinach a day"had a lower risk of developing dementia, while
higher nitrate and nitrite intake from red meat, processed meat, and
even drinking water was linked to a greater...
risk | ||||||||||||||||||
| Article: | /releases/2026/06/260606075852.htm https://www.sciencedaily.com/releases/2026/06/260606075852.htm | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| PRIME AGING BRAIN | |||||||||||||||||||
Zzc23-000 | Advanced Alzheimers Patient Regained Speech, Memory, and Bladder Control After a Single Psilocybin Dose | ||||||||||||||||||
| Quote: |
According to the report, she had become largely monosyllabic,
demonstrated profound cognitive impairment, chronic urinary
incontinence, impaired mobility, dysphagia, executive dysfunction, and
severe reduction in spontaneous communication and emotional engagement.
After receiving a single 5g oral dose of psilocybin-containing
mushrooms (Enigma strain), the patient reportedly experienced rapid and
sustained functional improvement across multiple domains....
To be clear, this is one published case report, not a randomized controlled trial, and causality cannot be established. | ||||||||||||||||||
| Comment: | Not without risk and not shown to be reproducable in others. | ||||||||||||||||||
| Article: | https://principia-scientific.com/advanced-alzheimers-patient-regained-speech-memory-and-bladder-control-after-a-single-psilocybin-dose/ | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
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Javilk's Research Links for Week 23 Updated 06/13/2026-02:39:38 AM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |