| Research Topics: |
| INDEX |
| AI-chat 4 |
| PRIME 24 |
| aging 8 |
| brain 6 |
| cancer 8 |
| cognition 5 |
| culture 1 |
| diabetes 2 |
| diagnostics 3 |
| economy 1 |
| genetics 2 |
| gut 1 |
| heart 5 |
| immune 2 |
| microbiome 1 |
| misc 1 |
| nutrition 6 |
| obesity 1 |
| pain 3 |
| politics 2 |
| pollution 2 |
| population 1 |
| practice 1 |
| privacy 1 |
| psychology 2 |
| religion 1 |
| reproduction 2 |
| sleep 2 |
| vaccine 3 |
|
Scanned: 2601 Evaluated: 105 Selected: 42 |
| PRIME BRAIN NUTRITION POLLUTION | |||||||||||||||||||
Aab23-002 | Role of taurine in the central nervous system | ||||||||||||||||||
| Quote: | Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating calcium transport and homeostasis, as an osmolyte, as a neuromodulator and as a neuroprotectant. The neurotransmitter properties of taurine are illustrated by its ability to elicit neuronal hyperpolarization, the presence of specific taurine synthesizing enzyme and receptors in the CNS and the presence of a taurine transporter system. Taurine exerts its neuroprotective functions against the glutamate induced excitotoxicity by reducing the glutamate-induced increase of intracellular calcium level, by shifting the ratio of Bcl-2 and Bad ratio in favor of cell survival and by reducing the ER stress. The presence of metabotropic taurine receptors which are negatively coupled to phospholipase C (PLC) signaling pathway through inhibitory G proteins is proposed, and the evidence supporting this notion is also presented. | ||||||||||||||||||
| Comment: | Can also reduce effects of acetaldehyde, a common pollutant from alcoholics and alcohol-gasoline blended automobile fuels. We have way too many alcoholic automobiles in California | ||||||||||||||||||
| Article: | https://pmc.ncbi.nlm.nih.gov/articles/PMC2994408/ | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| PRIME AGING BRAIN COGNITION | |||||||||||||||||||
Aac23-000 | Is Coconut Oil A Possible Cure for Alzheimers? | ||||||||||||||||||
| Quote: |
Since 2003, approximately 99 percent of Alzheimers drug trials have
failed to live up to expectations (Cummings, Alzheimers Research
Therapy, 2019); one analysis pegs the pipeline failure rate at 99.6
percent (Life Sciences, 2022)....
HHS Secretary Robert F. Kennedy Jr. has described the amyloid pipeline as built on "utter corruption" (Science, May 14, 2025), and in January 2026 he appointed a new Federal Alzheimers Advisory Council chair and ten new members tasked with broadening the agenda beyond amyloid.... In 2005, Brown University researchers led by Dr. Suzanne de la Monte examined the brains of Alzheimers patients with no history of diabetes. They found insulin resistance and insulin deficiency in every brain, and coined the term Type 3 diabetes (de la Monte Wands, J. Diabetes Sci. Tech., 2008). The dysfunction begins 10 to 20 years before symptoms (de la Monte, 2014). ... | ||||||||||||||||||
| Article: | https://principia-scientific.com/is-coconut-oil-a-possible-cure-for-alzheimers/ | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| AGING BRAIN COGNITION | |||||||||||||||||||
Mge23-026 | Multi-ancestry analysis of POLG variants in Parkinsons disease | ||||||||||||||||||
| Quote: | Conclusions POLG variants are overall rare in PD. The identification of rare pathogenic variants among PD cases suggests that POLG-related mitochondrial dysfunction may contribute to PD in isolated instances, particularly under recessive inheritance. Our findings support a role for POLG variants in select cases and underscore the need for larger-scale sequencing and functional studies. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.06.07.26354811v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.06.07.26354811v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Yi Wen Tay Inas Elsayed Dennis Yeow Mikayla James Pin-Jui Kung Laurel Screven Allison A. Dilliott Roy N. Alcalay Zih-Hua Fang Ai Huey Tan span classnlm-collab data-hwp-idcollab-1the Global Parkinsons Genetics Program (GP2) Carolyn M Sue Lara M Lange Maria Teresa Perian, | ||||||||||||||||||
| Search Words: |
| ||||||||||||||||||
| BRAIN | |||||||||||||||||||
Mne23-026 | A novel diagnostic intracranial EEG biomarker in MOGHE | ||||||||||||||||||
| Quote: | Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a recently recognized cause of drug-resistant focal epilepsy. It is often MRI-negative or shows imaging features mimicking focal cortical dysplasias, which makes recognition difficult and limits presurgical counseling. We aimed to identify an intracranial EEG (iEEG) biomarker that distinguishes MOGHE from other developmental brain lesions encountered in epilepsy surgery. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.06.05.26355018v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.06.05.26355018v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Vadym Gnatkovsky Ekaterina Poguzhelskaya Valeri Borger Rainer Surges Kerstin Alexandra Klotz Valentina Zschernack Till Hartlieb Manfred Kudernatsch Ahmed Gaballa Thomas Cloppenborg Friedrich G. Woermann Thilo Kalbhenn Hajo Hamer Stephanie Gollwitzer Stefan Rampp Daniel Delev Florian Mayer Karl Rssler Valerie Anne Quinot Angelika Mhlebner Rafael Toledano Antonio Gil-Nagel Roland Coras Ingmar Blmcke Katja Kobow, | ||||||||||||||||||
| PRIME AGING BRAIN COGNITION | |||||||||||||||||||
Sda233-013 | Scientists Found a New Alzheimers Trigger and a Drug That Stops It | ||||||||||||||||||
| Quote: |
GRK2 exists in two forms inside cells. One form functions normally,
while the other becomes inactive through cellular processes. The
researchers found that the inactive version accumulates in large
amounts in the brains of people with dementia. Similar patterns were
also observed in mice that develop Alzheimers-like symptoms....
"The GRK2 aggregates block the pores of the mitochondria, reducing the amount of energy they can supply and leading to a situation of stress inside the cells," Quitterer explains. The team also found that inactive GRK2 appears to increase the production of amyloid beta, a protein fragment widely associated with Alzheimers disease. | ||||||||||||||||||
| Article: | /releases/2026/06/260608035959.htm /releases/2026/06/260608035959.htmhttps://www.sciencedaily.com/releases/2026/06/260608035959.htm | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| PRIME AGING BRAIN | |||||||||||||||||||
Zzc23-000 | Advanced Alzheimers Patient Regained Speech, Memory, and Bladder Control After a Single Psilocybin Dose | ||||||||||||||||||
| Quote: |
According to the report, she had become largely monosyllabic,
demonstrated profound cognitive impairment, chronic urinary
incontinence, impaired mobility, dysphagia, executive dysfunction, and
severe reduction in spontaneous communication and emotional engagement.
After receiving a single 5g oral dose of psilocybin-containing
mushrooms (Enigma strain), the patient reportedly experienced rapid and
sustained functional improvement across multiple domains....
To be clear, this is one published case report, not a randomized controlled trial, and causality cannot be established. | ||||||||||||||||||
| Comment: | Not without risk and not shown to be reproducable in others. | ||||||||||||||||||
| Article: | https://principia-scientific.com/advanced-alzheimers-patient-regained-speech-memory-and-bladder-control-after-a-single-psilocybin-dose/ | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
|
Javilk's Research Links for Week 23 Updated 06/13/2026-02:39:38 AM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |