PRIME AGING NUTRITION
Aaa25-003	Scientists say most people need more protein than current guidelines suggest
	Quote:	A new review suggests that doing more exercise and eating more protein than current minimum recommendations may help people stay stronger, sharper, and more independent as they age. The goal isnt building a beach bodyits extending healthspan and maintaining the ability to fully enjoy life for decades longer.
	Article:	http://www.sciencedaily.com/releases/2026/06/260622091429.htm
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AGING DIABETES KIDNEYS NUTRITION PAIN
Aab25-001	How DMSO Heals The Nerves Eliminates Pain
	Quote:	DMSO is an "umbrella remedy" whose combination of therapeutic properties (improving circulation, reducing inflammation, protecting cells, and reviving dying ones) makes it uniquely suited to treat a variety of conditions, particularly "incurable" neurological disorders and the chronic pain that accompanies them.... Hundreds of readers have reported it transforming chronic neuropathic pain, migraines, fibromyalgia, and nerve damage from diabetes, chemotherapy, vaccines, and surgery, often after years of failed conventional treatments.
	Comment:	Very interesting article. Mediocal researcher Tom Nufert got me interested in topical DMSO for some issues I had.
	Article:	https://principia-scientific.com/how-dmso-heals-the-nerves-eliminates-pain/
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AGING BRAIN DIAGNOSTICS GUT
Aab25-003	Diagnosing Neurodegenerative Diseases by Label-Free 3-D Imaging of Intestinal Samples
	Quote:	Together, our results establish label-free AF imaging as a rapid and clinically compatible strategy for detecting enteric neurodegenerative pathology. This approach provides a framework for the future development of ENS-based biomarkers and supports the use of volumetric intestinal imaging for early diagnosis of neurodegenerative diseases.
	Article:	https://www.biorxiv.org/content/10.64898/2026.06.15.732258v1
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AGING LUNGS
Mbr25-003	Physiological Aging of the Respiratory System (PARS): from development to application
	Quote:	Conclusions Clinically stable outpatients with elevated NRR have an increased prevalence of DM. Additional studies are needed to investigate whether the mechanism is autonomic neuropathy and whether monitoring NRR can detect early complications of DM.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.15.26355186v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.15.26355186v1.full-text
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	Search Authors:	Smitha Edakalavan Jessica Bon S Mehdi Nouraie,
AGING BRAIN CANCER
Mca25-003	A Brain-Aging Transcriptomic Signature Reclassifies WHO Glioma Grade and Predicts Survival Independently of IDH Status: A Multi-Cohort Study
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.10.26355414v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.10.26355414v1.full-text
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	Search Authors:	Mohamed Saadawy osama khatan Eslam Saadawy,
PRIME AGING CANCER
Mca25-008	A Poisson Process Life Expectancy framework for optimising patient lifetime during chemotherapy
	Quote:	Mortality is modelled as a Poisson processes, a framework that enables the patients expected lifetime to be computed. The model and objective are biologically interpretable and can in principle be calibrated using clinical data. We demonstrate the approach for a logistic tumour growth model, illustrating the trade-offs between tumour control and toxicity.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.15.26354436v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.15.26354436v1.full-text
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	Search Authors:	Byron D. E. Tzamarias Nigel J. Burroughs,
AGING COGNITION HEART
Mcr25-008	Postoperative Cognitive Decline in Older Patients with Cardiovascular Disease and Preoperative Mild Cognitive Impairment
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355755v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355755v1.full-text
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	Search Authors:	Mara Mata Magali Gonzlez-Colao Harmand Pablo Csar Prada-Arrondo Alberto Domnguez-Rodrguez Jose Barroso Ivn Galtier,
AGING EXERCISE HEART METABOLISM
Mdb25-002	Joint association of C-reactive protein-triglyceride glucose index-frailty index and non-exercise estimated cardiorespiratory fitness with all-cause mortality in adults aged 45 years with cardiovascular-kidney-metabolic syndrome stages 0"3: a cross-cohort study using NHANES and CHARLS
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355835v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355835v1.full-text
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	Search Authors:	Jie An Qianhua Feng Jie Li Ya Luo Meng Yu Min Xu Dandan Yang Qiang She,
PRIME AGING BRAIN
Mge25-003	A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation
	Quote:	Understanding the regulatory consequences of genetic variation in the aging human brain requires molecular maps that span brain regions, cell types and regulatory modalities. We present the Alzheimers Disease Sequencing Project Functional Genomics (FunGen-AD) xQTL Atlas, a harmonized resource of molecular quantitative trait loci from four postmortem brain studies, ROSMAP, MSBB, Knight-ADRC and MiGA. The atlas integrates histone acetylation, DNA methylation, gene expression, splicing and protein abundance QTLs across 14 brain regions, 7 major cell types and 17,566 samples, with standardized association, significance-filtered and fine-mapping outputs.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.05.21.26353713v2
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.05.21.26353713v2.full-text
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	Search Authors:	Jeffrey Cifello Ru Feng Francis P. Grenn Luke Carter Anjing Liu Hao Sun Ruixi Li Jenny Anak Empawi Emily Greenfest-Allen Zivadin Katanic Otto Valladares Amanda B. Kuzma Heather White Lindsay A. Farrer Alison M. Goate Towfique Raj Minghui Wang Carlos Cruchaga Li-San Wang Hans Klein Han Chen span classnlm-collab data-hwp-idcollab-1ADSP Functional Genomics Consortium Philip L. De Jager Edoardo Marcora Julia TCW Xiaoling Zhang Pavel P. Kuksa Gao Wang Yuk Yee Leung,
AGING BRAIN COGNITION
Mgr25-002	Grey- and white-matter resilience to tau, cognition and sex in Alzheimers disease
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355812v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355812v1.full-text
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	Search Authors:	S. Boutin B. Houz C. Bedetti A. Pichet Binette S.M. Brambati span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative,
AGING
Mgr25-010	Effect of levodopa treatment on gait in older adults with mild parkinsonian signs
	Quote:	Conclusion Our preliminary data suggest that sustained levodopa treatment (one week) in conjunction with carbidopa pre-treatment and concomitant carbidopa supplementation is feasible in slow walking older adults with MPS. Moreover, the data indicate potential efficacy, showing improvements in cadence, and step durations.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.04.26354926v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.04.26354926v1.full-text
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	Search Authors:	Chatkaew Pongmala Stiven Roytman Miriam van Emde Boas Robert Vangel Caterina Rosano Nicolaas Bohnen,
AGING BRAIN
Mne25-002	Instantaneous-Frequency EEG Microstate Dynamics Stratify Motor Subtypes in Parkinsons Disease
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.09.26355312v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.09.26355312v1.full-text
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	Search Authors:	Sou Nobukawa Hirohisa Watanabe,
PRIME AGING BRAIN BRAINWAVE
Mne25-003	Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinsons disease
	Quote:	Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is hypothesized to improve motor symptoms in Parkinsons disease (PD) by suppressing pathologically elevated beta activity and promoting "prokinetic" gamma activity in the cortico-basal ganglia-thalamo-cortical loop. Advances in bidirectional DBS devices have revealed that stimulation can modify gamma oscillations via subharmonic entrainment
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.10.26354720v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.10.26354720v1.full-text
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	Search Authors:	Maria Shcherbakova Stephanie Cernera Amelia G. Hahn Simon Little Philip A. Starr,
PRIME AGING BRAIN SLEEP
Mne25-011	Preserved Medial Temporal Lobe Flexibility Predicts Memory Generalization Only in the Context of Good Sleep Quality among Older African Americans
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.15.26355704v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.15.26355704v1.full-text
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	Search Authors:	Payton White Miray Budak Soodeh Moallemian Bernadette A. Fausto Mark A. Gluck,
AGING BRAIN BRAINWAVE COGNITION
Mne25-020	Substantia Nigra and Subthalamic Nucleus Deep Brain Stimulation Exert Opposing Effects on Novelty Recognition in Parkinsons Disease
	Quote:	These behavioral effects mapped onto target-dependent parieto-occipital and SNvisual retrieval pathways, supporting a model in which DBS bidirectionally regulates recognition memory through target- and frequency-dependent subcorticalcortical circuits.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.17.26355856v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.17.26355856v1.full-text
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	Search Authors:	Bingxin Li Chenguan Jiang Yan Liu Zhou Yang Anbang Yao Xiaoyu Zhang Yuye Liu Hutao Xie Barbara Hollunder Bryan Strange Anchao Yang Fangang Meng Jianguo Zhang Changming Wang Ningfei Li Lin Shi,
AGING
Mne25-022	Plasma Proteomic Analysis of APOE 4 Homozygotes Identifies Preclinical Alzheimers Disease Alterations Potentially Modulated by Semaglutide
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v2
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.14.26346321v2.full-text
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	Search Authors:	Eric B. Dammer Shiva Afshar Shijia Bian Nicholas T. Seyfried span classnlm-collab data-hwp-idcollab-1The Global Neurodegeneration Proteomics Consortium (GNPC) Allan I. Levey Juan Fortea Erik C.B. Johnson,
AGING LANGUAGE
Mot25-013	Age-related changes in acoustic cue use for speech-in-speech perception
	Quote:	Age group analysis revealed that older adults (aged 40 ) performed significantly more poorly on all cue conditions of the speech-in-speech recognition task relative to younger adults. Age-related changes in auditory sensory processing may therefore impair older adults speech-in-noise perception by reducing their ability to use acoustic cues for segregating target and competing speech.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.17.26355866v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.17.26355866v1.full-text
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	Search Authors:	Elizabeth Fish Mishaela DiNino,
AGING BRAIN COGNITION DIAGNOSTICS
Mpy25-018	Blood-Based Biomarkers Predict Differential Longitudinal Decline in Alzheimers Disease Psychosis: Evidence from Two Cohorts
	Quote:	DISCUSSION ADP exhibited accelerated cognitive decline across domains driven by a distinct biomarker landscape compared to non-psychotic AD. Plasma ptau181 demonstrated broader domain-specific associations with decline in ADP than other blood-based biomarkers and associated exclusively with executive function impairment, indicating its unique utility for predicting cognitive trajectories in this pathophysiological subtype.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.18.26355956v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.18.26355956v1.full-text
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	Search Authors:	Jesus J. Gomar Marc L. Gordon Erica Christen Luca Giliberto Linda Keehlisen Michelle Gong Nichole Hoehn Emma Morley Allyson ONeil Danica Wuelfing Kishore Malyavantham Blaine Greenwald Philippe Marambaud Leslie Adrien Heidy Jimenez Peter Davies Jeremy Koppel,

Javilk's Research Links for Week 25
Updated 06/27/2026-03:36:32 AM
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Aaa25-003

Scientists say most people need more protein than current guidelines suggest

Aab25-001

How DMSO Heals The Nerves Eliminates Pain

Aab25-003

Diagnosing Neurodegenerative Diseases by Label-Free 3-D Imaging of Intestinal Samples

Mbr25-003

Physiological Aging of the Respiratory System (PARS): from development to application

Mca25-003

A Brain-Aging Transcriptomic Signature Reclassifies WHO Glioma Grade and Predicts Survival Independently of IDH Status: A Multi-Cohort Study

Mca25-008

A Poisson Process Life Expectancy framework for optimising patient lifetime during chemotherapy

Mcr25-008

Postoperative Cognitive Decline in Older Patients with Cardiovascular Disease and Preoperative Mild Cognitive Impairment

Mdb25-002

Joint association of C-reactive protein-triglyceride glucose index-frailty index and non-exercise estimated cardiorespiratory fitness with all-cause mortality in adults aged 45 years with cardiovascular-kidney-metabolic syndrome stages 0"3: a cross-cohort study using NHANES and CHARLS

Mge25-003

A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation

Mgr25-002

Grey- and white-matter resilience to tau, cognition and sex in Alzheimers disease

Mgr25-010

Effect of levodopa treatment on gait in older adults with mild parkinsonian signs

Mne25-002

Instantaneous-Frequency EEG Microstate Dynamics Stratify Motor Subtypes in Parkinsons Disease

Mne25-003

Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinsons disease

Mne25-011

Preserved Medial Temporal Lobe Flexibility Predicts Memory Generalization Only in the Context of Good Sleep Quality among Older African Americans

Mne25-020

Substantia Nigra and Subthalamic Nucleus Deep Brain Stimulation Exert Opposing Effects on Novelty Recognition in Parkinsons Disease

Mne25-022

Plasma Proteomic Analysis of APOE 4 Homozygotes Identifies Preclinical Alzheimers Disease Alterations Potentially Modulated by Semaglutide

Mot25-013

Age-related changes in acoustic cue use for speech-in-speech perception

Mpy25-018

Blood-Based Biomarkers Predict Differential Longitudinal Decline in Alzheimers Disease Psychosis: Evidence from Two Cohorts