Research
Topics:
INDEX
MCS 3
PRIME 37
aging 18
brain 25
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unk
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war-confl
 
Scanned: 4202
Evaluated: 821
Selected: 129

 
    AGING    BRAIN    DIAGNOSTICS    GUT   

Aab25-003

Diagnosing Neurodegenerative Diseases by Label-Free 3-D Imaging of Intestinal Samples

Quote: Together, our results establish label-free AF imaging as a rapid and clinically compatible strategy for detecting enteric neurodegenerative pathology. This approach provides a framework for the future development of ENS-based biomarkers and supports the use of volumetric intestinal imaging for early diagnosis of neurodegenerative diseases.
Article: https://www.biorxiv.org/content/10.64898/2026.06.15.732258v1
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    AGING    BRAIN    CANCER   

Mca25-003

A Brain-Aging Transcriptomic Signature Reclassifies WHO Glioma Grade and Predicts Survival Independently of IDH Status: A Multi-Cohort Study

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.10.26355414v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.10.26355414v1.full-text
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Search Authors: Mohamed Saadawy osama khatan Eslam Saadawy, 
    BRAIN    DENTAL    PAIN   

Mde25-008

Personalized Brain-Based Analgesia Detection with Portable fNIRS and AI

Quote: Neuroimaging-based pain decoding faces two underappreciated challenges: between-subject variability that prevents classifiers from generalizing across patients, and within-session cross-validation designs that inflate reported accuracy by conflating within- and between-person variance. Here we address both using portable functional near-infrared spectroscopy (fNIRS) during pharmacologically verified local nerve anesthesia.
Abstract: https://www.medrxiv.org/content/10.64898/2026.05.20.26353377v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.20.26353377v1.full-text
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Search Authors: Cristian Minoccheri Pangyu Joo Xiao-Su Hu Hafsa Affendi Fadi Elayyan Angeline Harville Neville J. McDonald Tatiana Botero Alexandre F. DaSilva, 
    BRAIN    DRUGS    PSYCHOLOGY   

Mga25-004

Elevated suicidal thoughts and behaviors, proximal suicide risk factors, and non-suicidal self-injury among adults reporting symptoms of Cannabinoid Hyperemesis Syndrome: Results from a national survey of US adults

Quote: Background Cannabinoid hyperemesis syndrome (CHS), a disorder characterized by severe nausea, vomiting, and abdominal pain among heavy cannabis users. We previously showed that CHS symptoms are associated with several behavioral and psychological characteristics linked to psychosocial impairment.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.26.26347185v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.26.26347185v2.full-text
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Search Authors: Brian M. Hicks Blair J. Whittington Amanda M. Price Paula Goldman Mark A. Ilgen, 
    BRAIN    DRUGS    PSYCHOLOGY   

Mga25-005

Links between Cannabinoid Hyperemesis Syndrome symptoms and drug use, mental health problems, antisocial behavior, and personality in a national survey of adults in the United States

Abstract: https://www.medrxiv.org/content/10.64898/2026.02.26.26347188v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.26.26347188v2.full-text
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Search Authors: Brian M. Hicks Amanda M. Price Blair J. Whittington Paula Goldman Mark A. Ilgen, 
    BRAIN    DRUGS    PSYCHOLOGY   

Mga25-006

Prevalence and Correlates of Symptoms of Cannabinoid Hyperemesis Syndrome in the United States

Quote: Results Overall, 2.7 of all respondents and 17.8 of respondents who used cannabis daily reported CHS-like symptoms. Respondents who were younger, female, identified as non-White, had lower income, had lower educational attainment, and endorsed cannabis-related use problems were more likely to be in the CHS symptom group than in the daily cannabis use group.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.25.26344780v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.25.26344780v2.full-text
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Search Authors: Mark A. Ilgen Amanda M. Price Paula Goldman Blair J. Whittington Brian M. Hicks, 
    PRIME    AGING    BRAIN   

Mge25-003

A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation

Quote: Understanding the regulatory consequences of genetic variation in the aging human brain requires molecular maps that span brain regions, cell types and regulatory modalities. We present the Alzheimers Disease Sequencing Project Functional Genomics (FunGen-AD) xQTL Atlas, a harmonized resource of molecular quantitative trait loci from four postmortem brain studies, ROSMAP, MSBB, Knight-ADRC and MiGA. The atlas integrates histone acetylation, DNA methylation, gene expression, splicing and protein abundance QTLs across 14 brain regions, 7 major cell types and 17,566 samples, with standardized association, significance-filtered and fine-mapping outputs.
Abstract: https://www.medrxiv.org/content/10.64898/2026.05.21.26353713v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.21.26353713v2.full-text
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Search Authors: Jeffrey Cifello Ru Feng Francis P. Grenn Luke Carter Anjing Liu Hao Sun Ruixi Li Jenny Anak Empawi Emily Greenfest-Allen Zivadin Katanic Otto Valladares Amanda B. Kuzma Heather White Lindsay A. Farrer Alison M. Goate Towfique Raj Minghui Wang Carlos Cruchaga Li-San Wang Hans Klein Han Chen span classnlm-collab data-hwp-idcollab-1ADSP Functional Genomics Consortium Philip L. De Jager Edoardo Marcora Julia TCW Xiaoling Zhang Pavel P. Kuksa Gao Wang Yuk Yee Leung, 
    BRAIN    GENETICS   

Mge25-008

AlphaGenome identifies a deep intronic variant in a family with PLA2G6-associated neurodegeneration: Closing the diagnostic gap in rare genetic diseases

Quote: Deep intronic variants that disrupt splicing are a known but underexplored source of pathogenic alleles, and systematic tools to evaluate them at scale have only recently emerged.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.10.26355004v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.10.26355004v1.full-text
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Search Authors: Sarah J Eger Greizy Lpez Luisa Fernanda Gmez Navarro Andrs Pea-Tauber J Nicholas Cochran Susan M Hiatt Nancy Gelvez Milena Garca-Garca Samuel Lobo Michael D Greicius Diana Luca Matallana Juliana Acosta-Uribe Kenneth S Kosik, 
    AGING    BRAIN    COGNITION   

Mgr25-002

Grey- and white-matter resilience to tau, cognition and sex in Alzheimers disease

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.16.26355812v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.16.26355812v1.full-text
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Search Authors: S. Boutin B. Houz C. Bedetti A. Pichet Binette S.M. Brambati span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative, 
    AGING    BRAIN   

Mne25-002

Instantaneous-Frequency EEG Microstate Dynamics Stratify Motor Subtypes in Parkinsons Disease

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.09.26355312v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.09.26355312v1.full-text
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Search Authors: Sou Nobukawa Hirohisa Watanabe, 
    PRIME    AGING    BRAIN    BRAINWAVE   

Mne25-003

Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinsons disease

Quote: Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is hypothesized to improve motor symptoms in Parkinsons disease (PD) by suppressing pathologically elevated beta activity and promoting "prokinetic" gamma activity in the cortico-basal ganglia-thalamo-cortical loop. Advances in bidirectional DBS devices have revealed that stimulation can modify gamma oscillations via subharmonic entrainment
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.10.26354720v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.10.26354720v1.full-text
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Search Authors: Maria Shcherbakova Stephanie Cernera Amelia G. Hahn Simon Little Philip A. Starr, 
    BRAIN   

Mne25-004

Intra-arterial recombinant human TNK tissue-type plasminogen activator (rhTNK-tPA) thrombolysis for acute medium vessel occlusion (MeVO-TNK): Study rationale and design

Comment: stroke
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.16.26355640v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.16.26355640v1.full-text
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Search Authors: Gang Deng Chen-Chen Liu Yi-Hui Wang Dong-Hui Ao Hao Huang Yi Xie Yi Zhang Qian-Qian Kong Ling-Ning Lan Pei-Xin Li Ting-Ting Qin Guo Li Sha-Bei Xu Xiang Luo, 
    PRIME    BRAIN   

Mne25-009

Targeted Proteomic Profiling of Nasal Fluid from the Brain-Nose Interface

Quote: Numerous disease-relevant proteins were observed in nasal fluid, including brain-derived tau species, phosphorylated tau, #945;-synuclein, axonal and synaptic markers, and glial-microglial mediators. To our knowledge, this is the first neurology-focused characterization of the nasal proteome from the vicinity of brain-nose interface using targeted multiplex platforms and the first to profile matched nasal fluid, CSF, and plasma, supporting nasal fluid from brain-nose interface as an additional source for biomarker development.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.16.26355519v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.16.26355519v1.full-text
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Search Authors: Mohammad Bashiri Maria Babu Gunter Weiss Stefan Kotschote Richard Metzler Hilary Wunderlich Agnese Petrera Elena De Domenico Heidi Theis Katrin Lehmann Frederik Heinrich Mir-Farzin Mashreghi Marion San Nicol Mareike Albert Sabine Mertzig, 
    PRIME    AGING    BRAIN    SLEEP   

Mne25-011

Preserved Medial Temporal Lobe Flexibility Predicts Memory Generalization Only in the Context of Good Sleep Quality among Older African Americans

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.15.26355704v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.15.26355704v1.full-text
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Search Authors: Payton White Miray Budak Soodeh Moallemian Bernadette A. Fausto Mark A. Gluck, 
    PRIME    BRAIN    PAIN   

Mne25-016

Anterior-superior hypothalamic enlargement as specific marker in episodic migraine: converging evidence from an independent discovery-replication design

Quote: Conclusions These findings provide evidence for subunit-specific hypothalamic structural alterations in migraine localized in the left anterior hypothalamic subunit. The stability of these differences over time and their absence in other chronic pain conditions suggest a migraine-specific structural organisation of hypothalamic circuitry.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.12.26355501v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.12.26355501v1.full-text
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Search Authors: Dan Liu Shengkun Peng Longlin Yin Xueyang Wen Bin Huang Keith Maurice Kendrick Benjamin Becker Dezhong Yao Stefania Ferraro, 
    PRIME    BRAIN    BRAINWAVE   

Mne25-017

Between Patterns and Predictions: Interpretable Latent EEG Representations for Clinical Insights

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.12.26355536v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.12.26355536v1.full-text
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Search Authors: Laura Krumm Robert Terziev Dominik D. Kranz M. Brandon Westover Christian Meisel, 
    AGING    BRAIN    BRAINWAVE    COGNITION   

Mne25-020

Substantia Nigra and Subthalamic Nucleus Deep Brain Stimulation Exert Opposing Effects on Novelty Recognition in Parkinsons Disease

Quote: These behavioral effects mapped onto target-dependent parieto-occipital and SNvisual retrieval pathways, supporting a model in which DBS bidirectionally regulates recognition memory through target- and frequency-dependent subcorticalcortical circuits.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.17.26355856v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.17.26355856v1.full-text
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Search Authors: Bingxin Li Chenguan Jiang Yan Liu Zhou Yang Anbang Yao Xiaoyu Zhang Yuye Liu Hutao Xie Barbara Hollunder Bryan Strange Anchao Yang Fangang Meng Jianguo Zhang Changming Wang Ningfei Li Lin Shi, 
    PRIME    BRAIN    NUTRITION   

Mpy25-005

The relationship between serotonin transporter occupancy and extracellular serotonin concentration is hyperbolic, not linear: implications for safely tapering antidepressants

Quote: Conclusions Our model predicts a hyperbolic relationship between SERT occupancy and extracellular serotonin concentrations, suggesting that changes in occupancy may not map proportionally onto serotonergic effect. These findings provide a potential mechanistic explanation for dose-dependent clinical effects of SRIs despite plateauing transporter occupancy and generate testable hypotheses regarding antidepressant tapering strategies. Empirical validation is warranted.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.09.26355019v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.09.26355019v1.full-text
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Search Authors: Daniel Cohrs Bryan Shapiro, 
    PRIME    BRAIN    HEART    PHYSICAL    PRIVACY    PSYCHOLOGY   

Mpy25-008

Cardiac rhythm development: A wearable device index of risk for physical and mental illness in adolescence

Quote: Conclusions The 24-hour cardiac rhythm is a passively measurable substrate of adolescent autonomic development that indexes transdiagnostic risk for psychiatric and cardiometabolic illness. ...
Comment: Amazing. Yet it should not be, as everything is interconnected and a build-up of bio- brain errors and resulting questionable interpretations eventually drifts a person away from realistic interpretations.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.12.26355405v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.12.26355405v1.full-text
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Search Authors: Eugenia Giampetruzzi Katharina Kircanski Daniel S. Pine Ian H. Gotlib, 
    BRAIN    COGNITION    PSYCHOLOGY   

Mpy25-011

Dissociable Thalamocortical Circuit Disruptions During Contextual Fear Renewal in PTSD

Quote: Conclusions State-specific reductions in MDm-hippocampal-cingulate and pulvinar-vmPFC connectivity during early fear renewal in PTSD highlight parallel thalamocortical alterations during flexible contextual threat updating. These alterations, along with the selective MDm-dACC association with symptom severity, nominate MDm-centered circuit as a hypothesis-generating focus for future mechanistic neuromodulation studies.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.15.26355743v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.15.26355743v1.full-text
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Search Authors: Muhammad Badarnee B. Isabel Moallem Israel Liberzon Mohammed R. Milad, 
    PRIME    BRAIN    COGNITION    PSYCHOLOGY    SLEEP   

Mpy25-013

Associations Between Social Responsiveness and Sleep disturbance are Modulated by Chronotype in Early Adolescence: Cross-Sectional and Prospective Findings from 10,108 Participants of the Adolescent Brain and Cognitive Development (ABCD) Study

Quote: Conclusions Social responsiveness assessed in early adolescence (age 11) were associated with sleep disturbance independent of multiple confounding factors and were prospectively associated with sleep disturbance at age 13 years. These findings contribute to the evidence that disruption of sleep and circadian timing may have a primary role in the mechanisms that mediate autistic traits.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.20.26356092v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.20.26356092v1.full-text
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Search Authors: Cathy Wyse Mailton Vasconcelos AungMyat Phyo Enya Nordon Lorna M. Lopez, 
    AGING    BRAIN    COGNITION    DIAGNOSTICS   

Mpy25-018

Blood-Based Biomarkers Predict Differential Longitudinal Decline in Alzheimers Disease Psychosis: Evidence from Two Cohorts

Quote: DISCUSSION ADP exhibited accelerated cognitive decline across domains driven by a distinct biomarker landscape compared to non-psychotic AD. Plasma ptau181 demonstrated broader domain-specific associations with decline in ADP than other blood-based biomarkers and associated exclusively with executive function impairment, indicating its unique utility for predicting cognitive trajectories in this pathophysiological subtype.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.18.26355956v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.18.26355956v1.full-text
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Search Authors: Jesus J. Gomar Marc L. Gordon Erica Christen Luca Giliberto Linda Keehlisen Michelle Gong Nichole Hoehn Emma Morley Allyson ONeil Danica Wuelfing Kishore Malyavantham Blaine Greenwald Philippe Marambaud Leslie Adrien Heidy Jimenez Peter Davies Jeremy Koppel, 
    BRAIN    COGNITION    NUTRITION    PSYCHOLOGY   

Mpy25-019

The Effects of Serotonergic systems on Cognitive Flexibility and Perseverative Thinking: a comparison between SSRI, classical psychedelics, and acute tryptophan depletion in a Multilevel Meta-Analysis

Quote: Conclusions Serotonergic interventions robustly reduce perseverative thinking but do not consistently alter performance on laboratory measures of cognitive flexibility. These findings suggest that serotonin may influence cognitive-emotional rigidity and the subjective experience of repetitive thought more strongly than objective executive task performance. The dissociation between task-based and phenomenological outcomes aligns with contemporary models of serotonergic plasticity and highlights perseverative thinking as a potentially transdiagnostic therapeutic target of serotonergic interventions.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.18.26355974v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.18.26355974v1.full-text
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Search Authors: Roi Basch Maya Cohen Leehe Peled-Avron, 
    BRAIN    COGNITION    PSYCHOLOGY   

Mpy25-021

Mapping abstraction and metacognition onto distinct transdiagnostic symptom profiles

Quote: transdiagnostic dimensions revealed more coherent associations with higher-order cognition than symptom-level analyses, highlighting the added value of examining psychopathology at the factor rather than the symptom level. These findings portray a hierarchical view of cognitive dysfunctions in psychopathology and point to representational and metacognitive processes as potential targets for transdiagnostic intervention.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.17.26354096v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.17.26354096v1.full-text
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Search Authors: Taiki Oka Yoshihiko Kunisato Kotaro Koizumi Misa Murakami Hugo Six Jessica E Taylor Aurelio Cortese, 
    BRAIN    COGNITION    LANGUAGE   

Mre25-005

Investigating naming error patterns after non-invasive brain stimulation and language treatment in persons with aphasia

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.08.26354856v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.08.26354856v1.full-text
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Search Authors: Myra J. Sydnor Micah Alan Johnson Becky Lammers Jamie L. Murter Martin Lindquist Rajani Sebastian, 

  Javilk's Research Links for Week 25
Updated 06/27/2026-03:36:32 AM
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