PRIME BRAIN COGNITION SLEEP
Aaa26-005	Warmer night-time temperatures are linked to poorer associative memory performance
	Quote:	Higher minimum, but not maximum, temperature was associated with poorer performance on Paired Associates, a task assessing associative memory. This pattern was observed for air temperature, wet-bulb temperature, and temperature percentile, suggesting poorer memory performance after warmer nights, both in absolute terms and relative to local seasonal norms. Temperature was not significantly associated with performance on any other task, including measures of short-term/working memory, visuospatial processing, language, attention, or executive function.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.18.26356006v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.18.26356006v1.full-text
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	Search Authors:	Anna Behler Renate Thienel Nicholas Bayliss Felicity Simpson Kerrie McAloney Jessica Adsett Nicholas G. Martin Michael Breakspear Michelle K. Lupton,
PRIME AGING BRAIN POLLUTION
Aab26-004	Common pesticide linked to more than double the risk of Parkinsons disease
	Quote:	The results suggest that chlorpyrifos can damage critical nerve cells involved in movement and may play a direct role in the development of Parkinsons disease.... Chlorpyrifos has been used on agricultural crops for decades. Although residential uses of the pesticide were banned in 2001 and agricultural applications faced restrictions in 2021, the chemical continues to be used on a variety of crops in the United States and remains common in many other countries.
	Article:	https://www.sciencedaily.com/releases/2026/06/260621111113.htm
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PRIME AGING BRAIN
Aac26-006	Scientists may have finally found how Alzheimers spreads through the brain
	Quote:	Under normal conditions, Arc plays an important role in brain function. The protein packages itself inside tiny membrane bound sacs known as extracellular vesicles (EVs), which travel from one neuron to another carrying important cellular signals. The researchers found that toxic Tau can exploit this natural communication system. By attaching itself to Arc inside these microscopic vesicles, Tau is able to travel from an unhealthy neuron into a healthy one, where it can continue spreading disease.
	Article:	https://www.sciencedaily.com/releases/2026/06/260630020521.htm
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PRIME BRAIN COGNITION
Mne26-007	Automated EEG Classification to Track Levels of Consciousness
	Quote:	As proof-of-principle for clinical implementation, we apply the classifier to a continuous EEG record from a patient with acute severe traumatic brain injury in the ICU, demonstrating its ability to yield continuous ABCD classifications that capture state fluctuations with high temporal and spatial resolution. The automated ABCD classifier allows for efficient analysis of continuous EEG records, facilitating the translation of the ABCD framework to the bedside for patients with acute severe brain injuries.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.18.26355981v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.18.26355981v1.full-text
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	Search Authors:	William H. Curley Andrew Hoopes David W. Zhou Mary M. Conte Jonathan D. Victor Nicholas D. Schiff Brian L. Edlow,
PRIME BRAIN COGNITION METABOLISM NUTRITION
Mne26-010	Metabolism of the antioxidant micronutrient ergothioneine as a plasma biomarker of cognitive resilience in older people with Alzheimers disease amyloid pathology
	Abstract:	https://www.medrxiv.org/content/10.1101/2025.07.31.25332054v4
	Full Text:	https://www.medrxiv.org/content/10.1101/2025.07.31.25332054v4.full-text
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	Search Authors:	Joyce R. Chong Irwin K. Cheah Richard M. Tang Barry Halliwell Christopher P. Chen Mitchell K.P. Lai,
AGING BRAIN COGNITION
Mne26-014	Routine implementation of -synuclein Seed Amplification Assays reveals high diagnostic performance and the limited value of Alzheimer disease fluid biomarkers for detecting -synuclein co-pathology
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.04.21.26351389v2
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.04.21.26351389v2.full-text
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	Search Authors:	Ocane Jourdan Marie Duchiron Joan Torrent Cdric Turpinat Etienne Mondesert Germain Busto Mehdi Morchikh Morgan Dornadic Constance Delaby Christophe Hirtz Lou Thizy Genevieve Barnier-Figue Florence Perrein Snejana Jurici Audrey Gabelle Karim Bennys Sylvain Lehmann,
AGING BRAIN COGNITION
Mpt26-003	TSPO PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia
	Quote:	CD68 burden was elevated in FTD, concentrated in white matter, and correlated with regional TSPO PET binding across pathologies (#946; 8.40, P 0.001). Only the CD68TSPO co-localised fraction tracked the PET signal, with no TSPO upregulation per-cell. The elevated TSPO PET signal in FTD likely reflects an increased burden of lysosome-enriched CD68 microglia, supporting TSPO PET as a microglial-burden biomarker in both FTLD-tau and FTLD-TDP.... Brain inflammation is a key feature of frontotemporal dementia (FTD). TSPO PET is widely used as an in vivo proxy for neuroinflammation, but whether the elevated signal reflects microglial, astrocytic, or vascular pathology is controversial.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.22.26356176v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.22.26356176v1.full-text
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	Search Authors:	Davi S. Vontobel Kei Onn Lai Mehtap Bacioglu George Nolan Daniel C Maddison Amelie Adamski Julia Goddard Noah L. Shapiro Harry Crook Tim Fryer Young Hong Sasvi Wijesinghe Franklin Aigbirhio Edward Avezov Kieren S. J. Allinson Annelies Quaegebeur John T OBrien James B Rowe Maria Grazia Spillantini Maura Malpetti,
BRAIN COGNITION HEART PSYCHOLOGY
Mpy26-004	Brain and vascular integrity related to cognitive and motor flexibility in autism: a study protocol
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.24.26356429v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.24.26356429v1.full-text
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	Search Authors:	Erik Domellf Andreas Johansson Sara Stillesj Linnea Karlsson Wirebring Carola Wiklund-Hrnqvist Anna-Maria Johansson Thomas Rudolfsson Anders Whlin Gustaf Wadenholt Malin Ekesryd Nordstrm Daniel Sfstrm,
BRAIN COGNITION PSYCHOLOGY
Mpy26-006	Early deviations from normative brain morphology and cortical microstructure in schizophrenia spectrum disorders
	Quote:	No interaction with SSD diagnosis was found. Furthermore, positive symptoms correlated negatively with CT and FA tract-based centiles, and showed widespread positive associations with raw cMD, whereas negative symptoms showed no associations. These findings underscore multimodal brain abnormalities that originate early in the course of SSD and their distinct associations with symptoms. Our results support the potential of both normative modelling and diffusion imaging markers to identify individualized early brain changes in SSD Among these, cMD emerges as a potential marker of SSD-related microstructural alterations.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.09.26343760v2
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.09.26343760v2.full-text
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	Search Authors:	Claudio Alemn-Morillo Natalia Garca-San-Martn Richard AI Bethlehem Patricia Segura Chloe Gomez Alessia Pasquini Pablo Salguero-Quiros Lena Dorfschmidt Manuel Muoz-Caracuel Rosa Ayesa-Arriola Javier Vzquez-Bourgon John Suckling Miguel Ruiz-Veguilla Benedicto Crespo-Facorro Rafael Romero-Garca,
BRAIN COGNITION PSYCHOLOGY REPRODUCTION
Mpy26-007	Sensitive periods for prenatal alcohol exposure shape internalizing symptoms across development
	Quote:	Prenatal alcohol exposure (PAE) is associated with lasting cognitive and neurodevelopmental deficits and can quadruple risk for depression later in life.... Conclusions and Relevance Our results highlight the second and third trimesters as potential sensitive periods for the impact of PAE on rising depressive symptoms from childhood to adolescence. Ultimately, these findings could inform the design of prevention programs, and facilitate targeted interventions to youth at elevated risk for depression.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.23.26356366v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.23.26356366v1.full-text
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	Search Authors:	Ka Ying Toby Law Madison E. Bigler Emma Kohrt Alex S. F. Kwong Alexandre A. Lussier,
BRAIN BRAINWAVE COGNITION PSYCHOLOGY RIGHTS
Mpy26-010	Cognitive-emotional responses to ultrasonic neuromodulation of anterior cingulate cortex
	Quote:	the largest effects (Cohens d #8764; 0.8) observed in pregenual and subgenual ACC in subjects with chronic pain and depression, respectively. These rapid trial-by-trial responses to ACC stimulation predicted subsequent improvements in pain and depression severity at 24 hours. Collectively, these findings reveal that transcranial ultrasound can robustly evoke immediate, target-specific, clinically meaningful changes in cognitive-emotional state, demonstrating the potential of ultrasonic neuromodulation as a tool for individualized probing of circuit function and dysfunction.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.22.26356085v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.22.26356085v1.full-text
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	Search Authors:	Brandon S. Cooper Vincent Koppelmans Thomas S. Riis Daniel A. Feldman Sarah Kwon Patrick Brashear Michael Guynn Akiko Okifuji Jan Kubanek Brian J. Mickey,
AGING BRAIN
Mre26-002	Better immediate declarative memory is associated with forgetting during locomotor adaptation in chronic stroke and in older adults
	Quote:	This relationship supports the hypothesis that declarative memory contributes to adaptation through a cognitively mediated fast process. These findings suggest that cognitive impairment contributes to altered adaptation following stroke and highlight the importance of considering cognitive factors when investigating motor learning mechanisms and rehabilitation outcomes in neurological populations.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355404v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.16.26355404v1.full-text
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	Search Authors:	S Lipior Y Yu ML Kelly AR Cain N Schweighofer KA Leech,
BRAIN IMMUNE
Mre26-004	Treadmill training with rhythmic auditory cueing and/or visual feedback for persons with Multiple Sclerosis: feasibility and effects on gait parameters in a clinical randomized controlled trial
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.06.18.26356023v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.06.18.26356023v1.full-text
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	Search Authors:	Philipp Krber Florian Wolf Jochen Saliger Jrn Nielsen Mareike Eschweiler,

Javilk's Research Links for Week 26
Updated 07/04/2026-03:43:26 AM
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Aaa26-005

Warmer night-time temperatures are linked to poorer associative memory performance

Aab26-004

Common pesticide linked to more than double the risk of Parkinsons disease

Aac26-006

Scientists may have finally found how Alzheimers spreads through the brain

Mne26-007

Automated EEG Classification to Track Levels of Consciousness

Mne26-010

Metabolism of the antioxidant micronutrient ergothioneine as a plasma biomarker of cognitive resilience in older people with Alzheimers disease amyloid pathology

Mne26-014

Routine implementation of -synuclein Seed Amplification Assays reveals high diagnostic performance and the limited value of Alzheimer disease fluid biomarkers for detecting -synuclein co-pathology

Mpt26-003

TSPO PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia

Mpy26-004

Brain and vascular integrity related to cognitive and motor flexibility in autism: a study protocol

Mpy26-006

Early deviations from normative brain morphology and cortical microstructure in schizophrenia spectrum disorders

Mpy26-007

Sensitive periods for prenatal alcohol exposure shape internalizing symptoms across development

Mpy26-010

Cognitive-emotional responses to ultrasonic neuromodulation of anterior cingulate cortex

Mre26-002

Better immediate declarative memory is associated with forgetting during locomotor adaptation in chronic stroke and in older adults

Mre26-004

Treadmill training with rhythmic auditory cueing and/or visual feedback for persons with Multiple Sclerosis: feasibility and effects on gait parameters in a clinical randomized controlled trial