| Research Topics: |
| INDEX |
| AI-chat 2 |
| MCS 2 |
| PRIME 35 |
| PRIO 1 |
| aging 10 |
| brain 12 |
| brainwave 2 |
| cancer 10 |
| climate 6 |
| cognition 7 |
| covid-19 1 |
| culture 2 |
| dental 1 |
| diabetes 5 |
| disease 2 |
| drugs 1 |
| economy 1 |
| election 1 |
| exercise 1 |
| gender 2 |
| genetics 3 |
| gut 5 |
| heart 6 |
| immune 5 |
| kidneys 3 |
| language 1 |
| metabolism 1 |
| microbiome 3 |
| misc 1 |
| nutrition 12 |
| obesity 1 |
| poison 1 |
| politics 5 |
| pollution 3 |
| privacy 3 |
| psychology 2 |
| reproduction 1 |
| rights 3 |
| sleep 1 |
| space 2 |
| unk |
| virus 1 |
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Scanned: 1782 Evaluated: 279 Selected: 72 |
| MCS PRIME POISON POLLUTION | ||||||||
Bbc28-004 | A covalent irreversible inhibitor binds in two mutually exclusive conformations to the active-site cysteine residue of human aldehyde dehydrogenase 1A3 | |||||||
| Quote: | Biochemical and biophysical tests confirmed that Z34 acts as a time-dependent, covalent, and irreversible binder to the active-site cysteine. In this work, we determined the Cryo-EM structure of the ALDH1A3-Z34 complex at 2.26 resolution, confirming the covalent attachment to the catalytic cysteine of Z34. Notably, two mutually exclusive covalent binding modes were observed: one occupying the substrate-binding pocket and the other the cofactor-binding region. Z34 displayed unexpected binding modes within the active site and holds promise as a lead compound for future drug development. | |||||||
| Article: | https://www.biorxiv.org/content/10.64898/2026.07.14.738401v1 | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Daniela Covaleda David Vizarraga Tulsi Upadhyay Jiyun Zhu Daniel Abegg Raquel Pequerul Martn Hugo Alexander Adibekian Ignacio Fita Xavier Pars Francesc Xavier Avils Matthew Boggyo Jaume Farrs, | |||||||
| MCS PRIME BRAIN COGNITION DRUGS PSYCHOLOGY | ||||||||
Sd283-001 | Common Constipation Drug May Help Clear Depression Brain Fog | |||||||
| Quote: | The researchers studied prucalopride, a medication currently approved for chronic constipation. The drug works by activating a specific serotonin receptor (the fourth serotonin receptor, or 5-HT4 R) found in both the gut and the brain. The research was supported by the National Institute for Health and Care Research (NIHR) Biomedical Research Centre: Oxford Health. | |||||||
| Article: | https://www.sciencedaily.com//releases/2026/07/260712011751.htm | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
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Javilk's Research Links for Week 28 Updated 07/17/2026-11:18:40 PM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |