PRIME GUT
Aef28-1025	Drug-Free Solution to Crohns Disease
	Quote:	Working with a functional medicine physician, Ott gradually stopped taking prescription medications and adopted a lifestyle focused on nutrition, regular exercise, and faith. He says those three pillars continue to guide his daily routine. After four years of following this approach, Ott says he feels healthier than ever.
	Article:	https://www.newsmax.com/health/health-news/crohns-drug-free-treatment/2026/07/10/id/1262417/
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PRIME CANCER GUT MICROBIOME NUTRITION
Bcb28-010	Gut microbiome derived folate metabolite suppresses colorectal cancer progression
	Quote:	Mechanistically, folinic acid acts as a signaling molecule that directly binds and inhibits the intracellular protease calpain-2. This interaction stabilizes epithelial E-cadherin protein expression and suppresses CRC epithelial-to-mesenchymal transition driving metastasis. Genetically manipulating gut microbial production of FA is sufficient to modulate CRC in vivo, even in the presence of chronic inflammation.
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.14.738490v1
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	Search Authors:	Rebecca Danner Juyeong Cho Zachary Detwiler Jonathan Williams Jiyoung Amanda Han Chang Yang Xavier Diebold Katerina Maeder Jonathan G. Van Vraken Allison S. Walker Cammie Lesser Snehal N. Chaudhari,
GUT KIDNEYS MICROBIOME NUTRITION
Mnu28-002	The effect of dietary fiber based on fermentability and viscosity on the gut microbial metabolites in chronic kidney disease: a systematic review and meta-analysis of experimental and clinical trials.
	Quote:	Conclusion Isolated dietary fiber reduces major gut-derived uremic solutes in CKD, with fermentability influencing metabolic responsiveness, but with minimal studies on viscous fibers. Larger, longer-duration trials with standardized reporting of total fiber intake and clinical endpoints are needed to guide evidence-based dietary recommendations in CKD. Statement of Significance This is the first systematic review and meta-analysis examining the effects of isolated dietary fiber on gut-derived metabolites comprising human and rodent models in CKD.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.07.09.26357677v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.07.09.26357677v1.full-text
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	Search Authors:	Seyedeh Nooshan Mirmohammadali Claudia Carrillo Jason B. Reed Brandon M. Kistler Hannah E Wilson Bruce Hamaker Sharon Moe Annabel Biruete,
AGING BRAIN GUT
Sd270-006	Experimental Drug Reverses Severe Fatty Liver Disease by Repairing the Gut
	Quote:	n experimental drug called DT-109 reversed severe fatty liver disease in animal studies by repairing the gut and preventing harmful toxins from damaging the liver. The discovery could open the door to a new class of treatments for MASH and potentially other diseases tied to gut health.
	Article:	https://www.sciencedaily.com//releases/2026/07/260711010116.htm
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GUT MICROBIOME
Sd285-006	Scientists Tested 39 Sweeteners and Found Unexpected Gut Effects
	Quote:	About three-quarters of the sweeteners affected the growth of at least one bacterial species. Several reduced or completely halted the growth of bacteria associated with a healthy digestive system. These findings suggest that some sweeteners are not simply inactive substances that pass through the digestive tract without interacting with the organisms living there.
	Article:	https://www.sciencedaily.com//releases/2026/07/260716023552.htm
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Javilk's Research Links for Week 28
Updated 07/17/2026-11:18:40 PM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.

Aef28-1025

Drug-Free Solution to Crohns Disease

Bcb28-010

Gut microbiome derived folate metabolite suppresses colorectal cancer progression

Mnu28-002

The effect of dietary fiber based on fermentability and viscosity on the gut microbial metabolites in chronic kidney disease: a systematic review and meta-analysis of experimental and clinical trials.

Sd270-006

Experimental Drug Reverses Severe Fatty Liver Disease by Repairing the Gut

Sd285-006

Scientists Tested 39 Sweeteners and Found Unexpected Gut Effects