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Scanned: 2595 Evaluated: 284 Selected: 69 |
| KIDNEYS | ||||||||
Bcb29-010 | Inactivation of HIF-P4H-1 Stabilizes IKK, Modulates Non-Canonical NF-B Signaling, and Sensitizes Cancer Cells to Cell Death | |||||||
| Quote: | Structural modeling and mutagenesis identify proline 367 hydroxylation as a critical determinant of IKK#945; turnover. Analysis of TCGA cohorts reveals an inverse correlation between HIF-P4H-1 and IKK#945; expression, with elevated HIF-P4H-1 associating with advanced tumor stage and reduced overall survival in clear cell renal cell carcinoma. Functionally, targeting HIF-P4H-1 sensitizes cancer cells to cell death and impairs proliferation, clonogenic growth, and migration. | |||||||
| Article: | https://www.biorxiv.org/content/10.64898/2026.07.17.739273v2 | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Karim Ullah Mizanur Rahman Farhan Quadir Valerio Izzi Ulrich Bergmann Jing Zhang Qing Zhang Rongxue Wu Joni M. Maki Johanna Myllyharju, | |||||||
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Javilk's Research Links Newsletter for Week 29 Updated 07/25/2026-03:15:16 AM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |