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Scanned: 2595
Evaluated: 284
Selected: 69

 
    BRAIN    COGNITION    PSYCHOLOGY   

Bne29-011

miR-10a-5p as a critical molecular regulator of dopaminergic impulsivity in the nucleus accumbens

Quote: Among the differentially expressed miRs, miR-10a-5p emerged as the strongest candidate: it was constitutively elevated in high-impulsive rats and upregulated by PPX in low- and mid-impulsive animals in both regions, thereby paralleling the trait-dependent behavioral effect of the drug. In vivo viral-mediated overexpression of miR-10a-5p confirmed its predicted downregulation of the PI3KAKTmTOR and BDNF pathways in the striatum, and, critically, overexpression restricted to the NAcc, but not the dorsal striatum, was sufficient to increase impulsive choice, recapitulating the pro-impulsive effect of PPX. These findings identify miR-10a-5p as a critical molecular regulator of impulsivity through its activity in the NAcc, providing a mechanistic link between dopaminergic perturbation, trait vulnerability, and ICDs, and opening new avenues for the development of miR-directed therapeutic strategies for these disorders.
Article: https://www.biorxiv.org/content/10.64898/2026.07.20.739499v1
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Search Authors: Yury V M Lages Thibault Dufourd Carole Carcenac Mathilde Roux Magali Bartolomucci Frederique Vossier David Mallet Robin Magnard Colin Deransart sabrina Boulet Pierre-Olivier Fernagut Sebastien Carnicella, 
    PSYCHOLOGY   

Moc29-003

The Mental Health of Farm Wives

Quote: Conclusions Farm wives and partners experience substantial mental health burdens linked to their diverse and often underrecognized roles within agricultural systems.
Abstract: https://www.medrxiv.org/content/10.64898/2026.07.20.26358460v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.07.20.26358460v1.full-text
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Search Authors: Sharon May R. M. Crossley, 
    BRAIN    PSYCHOLOGY    STRESS   

Mpy29-005

Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: A systematic review and meta-analysis

Quote: Conclusion Childhood Aadversity was not consistently associated with hippocampal or amygdala volume alterations in PD and BD. More consistent evidence emerged for reduced GMV in prefrontal regions, suggesting that neurobiological impact of CA may be more robustly captured at the cortical level.
Abstract: https://www.medrxiv.org/content/10.64898/2026.07.17.26358306v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.07.17.26358306v1.full-text
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Search Authors: Teya Petrova Andreas Tennifjord Daniela Cavero Aisling Holohan Melissa Kizilkaya Ava Ebrahimian-Roodbari Ines Lepreux Marie Reimer Lucia Sideli Romayne Gadelrab Giulia Trotta Victoria Rodriguez Ole Andreassen Paul Klauser Luis Alameda Monica Aas, 
    AI-CHAT    PRIME    LANGUAGE    PSYCHOLOGY   

Mpy29-007

Prompt Engineering Limitations: Preliminary Evaluation of Large Language Models for Psychotherapy Safety

Quote: Models frequently validated harmful statements, colluded with hallucinations, minimized symptoms, or used stigmatizing language, including in the newest and largest models. These failures reflect structural limitations such as lack of memory, insufficient contextual reasoning, and training-related biases. Prompt engineering alone is therefore insufficient for safe AI-mediated psychotherapy; clinician-guided fine-tuning, integrated safety mechanisms, and system-level over-sight will be required. This work provides early evidence motivating deeper clinician-led evaluation and safety-oriented model development.
Abstract: https://www.medrxiv.org/content/10.64898/2026.07.16.26358261v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.07.16.26358261v1.full-text
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Search Authors: Nhat Ngo Giang Dao Akane Sano, 
    COVID-19    PSYCHOLOGY   

Sd291-012

Common Antidepressant May Ease Long COVIDs Crushing Fatigue

Article: https://www.sciencedaily.com//releases/2026/07/260718010158.htm
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  Javilk's Research Links Newsletter for Week 29
Updated 07/25/2026-03:15:16 AM
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