PRIME BRAIN IMMUNE
Bbc30-006	Mass Spectrometry-Based Multiomic Profiling Defines Proteome, Lipidome, and Metabolome Remodeling in IFN- and LPS-Stimulated BV-2 Microglial Cells
	Quote:	Process-level integration of significant features revealed coordinated remodeling of inflammatory protein programs with lipid storage, membrane remodeling, nucleotide metabolism, amino acid availability, phospholipid precursor abundance, nitric oxide-associated metabolism, and redox/osmolyte pathways. These findings demonstrate that IFN-#947; and LPS-induced activation of BV-2 cells involves integrated immune, lipid, and metabolic adaptation rather than isolated induction of canonical inflammatory mediators. This integrated multiomic framework provides a resource for investigating how lipid and metabolic remodeling regulate microglial inflammatory states.
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.27.741024v1
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	Search Authors:	Abraham M Borst Matthew R Eskritt Kaitlyn T Mang Melissa R Pergande,
BRAIN COGNITION
Bne30-006	Climbing fibers encode the gradient of a loss function for the cerebellum
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.27.741034v1
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	Search Authors:	Jafar Doostmohammadi Nazanin Mohammadrezaei Hisham Elseweifi Alana Chandler Elijah Taeckens Reza Shadmehr,
PRIME BRAIN COGNITION
Bne30-008	Astrocytes instructively regulate neuronal translation
	Quote:	we identified astrocyte-secreted apolipoprotein E (APOE) and its associated cargo as a negative regulator of neuronal translation that contributed to the decreased translation induced by neurotoxic reactive astrocytes. We also found that astrocyte-secreted signals required neuronal endocytosis to influence translation and drove synaptic remodeling dependent on glutamatergic signaling and neuronal mTORC1 activity.
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.27.741020v1
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	Search Authors:	Wendy Liu Carson C Schultz Eshaan A Khan Mauricio M Oliveira Srinidhi V Kalavai Charles J Sheehan Xunzhao Zhang Richard Sam Eric Klann,
BRAIN PSYCHOLOGY
Bne30-010	A longitudinal naturalistic fMRI study of trait anxiety and cross-phase consistency in subjective fear signature expression
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.24.740524v1
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	Search Authors:	Chung-Lien W Chen Feng-Chun B Chou Po-Yuan A Hsiao Pin-Hao Andy Chen,
BRAIN BRAINWAVE COGNITION PSYCHOLOGY
Bne30-011	Dissociable Anterior and Posterior Beta-Burst Dynamics Track Thought Disorder in Schizophrenia
	Quote:	Conclusion: Schizophrenia was associated with dissociable anterior and posterior beta-burst abnormalities that tracked objective speech markers of thought disorder. These findings suggest impaired hierarchical coordination of predictive beta signalling as a candidate mechanism linking intrinsic network dysfunction to disorganized thought.
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.27.740959v1
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	Search Authors:	Hsi T. Wei Lindsey Power Rukun Dou Sylvain Baillet Lena Palaniyappan,
PRIME BRAIN COGNITION PSYCHOLOGY
Sd290-003	A Single Dose Reversed Autism-like Symptoms in Adult Mice Within Hours/a
	Quote:	A UCLA Health study in mice has found that inflammation during pregnancy can produce lasting autism-like changes in offspring. The researchers also discovered that many of the resulting brain and behavioral effects could be improved rapidly in adulthood, although only temporarily, with a single dose of the immune-suppressing drug rapamycin.
	Article:	https://www.sciencedaily.com//releases/2026/07/260724061436.htm
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PRIME AGING BRAIN IMMUNE
Sd301-007	A Hidden Alzheimers Tipping Point May Decide Who Gets Dementia/a
	Quote:	In other words, a cellular state that was associated with neurodegeneration in some people appeared to be separated from damaging effects in others. This suggests that resilience is not simply a matter of avoiding Alzheimers pathology. It may also depend on how the brain controls, redirects, or adapts its response to that pathology.
	Article:	https://www.sciencedaily.com//releases/2026/07/260726015257.htm
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PRIME AGING BRAIN NUTRITION
Sd302-040	Eating Within 8 Hours May Help Keep the Aging Brain Sharp/a
	Quote:	"Losing weight alone will ward off some of the aging-related cognitive decline, and these data suggest that there may be additional benefits if you stop eating 4 hours prior to going to sleep and reduce food intake to 8-9 hours per day, compared to the usual eating window of 12 hours per day," said Sue Shapses, PhD, RD, DFASN, professor at Rutgers University and Rutgers-RWJ Medical Center, the studys Principal Investigator.
	Article:	https://www.sciencedaily.com//releases/2026/07/260727012125.htm
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AGING BRAIN SLEEP
Sd305-003	Scientists Discover Why Poor Sleep May Harm Some Brains More/a
	Quote:	The brains waste-removal process becomes especially active during sleep. Scientists believe it helps clear potentially harmful proteins, including proteins associated with Alzheimers disease. Researchers found that the effects of sleep appeared to vary depending on which version of the AQP4 gene a person carried.
	Article:	https://www.sciencedaily.com//releases/2026/07/260729051529.htm
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AI-CHAT AGING BRAIN
Sd305-007	AI Can Tell If Your Brain Is Aging Faster Than You Are/a
	Quote:	A persons sleeping brain may reveal warning signs of dementia long before memory problems begin. Researchers used machine learning to analyze EEG recordings from about 7,000 adults and found that an older-than-expected "brain age" was tied to a sharply higher dementia risk. Every additional 10 years of brain aging raised that risk by nearly 40.
	Article:	https://www.sciencedaily.com//releases/2026/07/260729051540.htm
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AGING BRAIN DIABETES OBESITY
Sd305-011	Scientists Discover How Obesity May Fuel Alzheimers Disease/a
	Quote:	The study, led by Houston Methodist researchers, examined how changes in body fat associated with obesity may send damaging signals to the brain. These signals appear to interfere with the brains immune system and contribute to the biological damage linked to Alzheimers disease.
	Article:	https://www.sciencedaily.com//releases/2026/07/260729051531.htm
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Javilk's Research Links Newsletter for Week 30
Updated 08/01/2026-01:13:17 AM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.

Bbc30-006

Mass Spectrometry-Based Multiomic Profiling Defines Proteome, Lipidome, and Metabolome Remodeling in IFN- and LPS-Stimulated BV-2 Microglial Cells

Bne30-006

Climbing fibers encode the gradient of a loss function for the cerebellum

Bne30-008

Astrocytes instructively regulate neuronal translation

Bne30-010

A longitudinal naturalistic fMRI study of trait anxiety and cross-phase consistency in subjective fear signature expression

Bne30-011

Dissociable Anterior and Posterior Beta-Burst Dynamics Track Thought Disorder in Schizophrenia

Sd290-003

A Single Dose Reversed Autism-like Symptoms in Adult Mice Within Hours/a

Sd301-007

A Hidden Alzheimers Tipping Point May Decide Who Gets Dementia/a

Sd302-040

Eating Within 8 Hours May Help Keep the Aging Brain Sharp/a

Sd305-003

Scientists Discover Why Poor Sleep May Harm Some Brains More/a

Sd305-007

AI Can Tell If Your Brain Is Aging Faster Than You Are/a

Sd305-011

Scientists Discover How Obesity May Fuel Alzheimers Disease/a