| Research Topics: |
| INDEX |
| AI-chat 1 |
| PRIME 37 |
| aging 12 |
| body 2 |
| brain 17 |
| brainwave 3 |
| cancer 7 |
| climate 3 |
| cognition 10 |
| covid-19 6 |
| crime 3 |
| culture 3 |
| diabetes 6 |
| diagnostics 2 |
| disease 3 |
| drugs 1 |
| energy 1 |
| exercise 3 |
| eyes 1 |
| genetics 12 |
| gut 3 |
| heart 15 |
| immune 8 |
| kidneys 5 |
| language 2 |
| metabolism 2 |
| microbiome 2 |
| nutrition 11 |
| obesity 2 |
| physical 2 |
| politics 2 |
| pollution 2 |
| population 2 |
| practice 2 |
| privacy 2 |
| psychology 14 |
| quantum 1 |
| reproduction 2 |
| rights 1 |
| sleep 2 |
| space 1 |
| tech 2 |
| unk |
| vaccine 2 |
| virus 2 |
| war-confl |
| war-cyber 1 |
|
Scanned: 3012 Evaluated: 322 Selected: 92 |
| PRIME BODY GENETICS METABOLISM NUTRITION OBESITY | |||||||||||||||||||
Aef32-1025 | FNIP1 variants are associated with favourable metabolism in 1 million humans | ||||||||||||||||||
| Quote: | FNIP1 knockdown in primary human hepatocytes induces lipid breakdown and lysosomal gene expression, while combined hepatic knockdown of Fnip1 with its paralogue Fnip2 or knockdown of its interactor Flcn protect against weight gain, reduce liver fat and enhance insulin sensitivity in mice fed a high-fat diet. Our study implicates the FNIP1 pathway in human energy metabolism and highlights its inhibition as a potential therapeutic strategy in cardiometabolic disease. | ||||||||||||||||||
| Article: | https://pubmed.ncbi.nlm.nih.gov/42557317/ | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| AGING GENETICS | |||||||||||||||||||
Mcr32-018 | Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes | ||||||||||||||||||
| Quote: | Conclusions An LE8-derived DNAm score was associated with lower cIMT across the life course and, to a lesser extent, across generations. These findings suggest that blood DNAm reflects cumulative cardiovascular health and vascular burden and may complement conventional cardiovascular risk assessment. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.07.26359994v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.07.26359994v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Binisha H. Mishra Emma Raitoharju Leo-Pekka Lyytikinen Nina Mononen Juhani S. Koskinen Jorma S.A. Viikari Katja Pahkala Suvi P. Rovio Juha Mykknen Markus Juonala Mika Khnen Olli T. Raitakari Terho Lehtimki Pashupati Prasad Mishra, | ||||||||||||||||||
| GENETICS POPULATION REPRODUCTION | |||||||||||||||||||
Mep32-021 | Population Differences in the Epidemiology, Phenotype, and Genetics of Hirschsprung Disease in the United States | ||||||||||||||||||
| Quote: | Genetically, the major difference in Blacks is the unique association with noncoding regulatory variation at the SOX10 gene not observed in Whites. Meaning These findings uncover significant population differences in incidence and clinical presentation, but limited qualitative but greater quantitative genetic differences, in Hirschsprung disease. Beyond being useful for understanding HSCR natural history and for genetic counseling, it begs for research on the causes of the variable frequency and presentations across populations. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.10.26360052v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.10.26360052v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Mingzhou Fu Hanna E Berk-Rauch Monica Erazo Sumantra Chatterjee Aravinda Chakravarti, | ||||||||||||||||||
| Search Words: |
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| GENETICS | |||||||||||||||||||
Mge32-008 | Analysis of spliceosome-related coding and noncoding genes and pseudogenes reveals novel candidates | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.06.26358951v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.06.26358951v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Olfa Messaoud Stephanie DiTroia Rahaf Tarawneh Daniel Marten Emily OHeir Melanie OLeary Lynn Pais Vijay Ganesh Moriel Singer-Berk span classnlm-collab data-hwp-idcollab-1Broad CMG and GREGoR consortium collaborators Monica Wojcik Kaitlin Samocha Heidi L Rehm Christina Austin-Tse Anne ODonnell-Luria, | ||||||||||||||||||
| DISEASE GENETICS | |||||||||||||||||||
Mge32-009 | Multi-ancestry admixture mapping reveals ancestry-associated disease loci in the UK Biobank | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.06.26359859v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.06.26359859v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Riccardo smeriglio Sonia Moreno-Grau Daniel Mas Montserrat Guhan Venkataraman David Bonet Caterina Fuses Manuel A Rivas Alessandro Savino Stefano Di Carlo Jordi Abante Alexander ioannidis, | ||||||||||||||||||
| AGING BRAIN GENETICS | |||||||||||||||||||
Mge32-013 | TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain | ||||||||||||||||||
| Quote: | These findings identify haplotype-specific associations with differential proteinopathy burden, illustrating how haplotype-resolved analyses can connect GWAS signals to candidate molecular pathways. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.11.26359568v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.11.26359568v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Alex N. Salazar Niccolo Tesi Sven J van der Lee Frank Koopmans Ka Wan Li Susan Rohde Maruelle Luimes Annemieke Rozemuller August B. Smit Marc Hulsman Henne Holstege, | ||||||||||||||||||
| DRUGS GENETICS | |||||||||||||||||||
Mge32-016 | Genotype-predicted drug response phenotypes and their co-occurrence with dispensed medicines among 738,531 participants in the UK Our Future Health study | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.11.26360205v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.11.26360205v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Christopher T. Rentsch Krishnan Bhaskaran Mirko Pavicic Helen R. Warren Julian Matthewman Eleanor Barry Imran Rafi Judith Hayward Clare Gerada Anoop Shah Patricia B. Munroe Matt J. Silver Munir Pirmohamed, | ||||||||||||||||||
| GENETICS HEART | |||||||||||||||||||
Mge32-020 | A loss-of-function mutation in the GTPase domain of MFN2, perverting mitochondrial dynamics, is associated with dilated cardiomyopathy | ||||||||||||||||||
| Quote: | The above findings collectively highlight the significant impact of the MFN2 mutation on mitochondrial dynamics and cellular health, suggesting a significant correlation with the pathogenesis of DCM. This finding could further open a door to develop a potential therapeutic target for DCM. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.10.26360061v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.10.26360061v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Mohini Gupta Amrita Mukhopadhyay Manohar lal Yadav Dharmendra Jain Bhagyalaxmi Mohapatra, | ||||||||||||||||||
| GENETICS KIDNEYS | |||||||||||||||||||
Mkd32-015 | A-to-I RNA editing in kidney tissue from patients with nephrotic syndrome | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.08.26359884v2 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.08.26359884v2.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Victoria Mezger Michelle T McNulty Dongwon Lee Matthew G. Sampson, | ||||||||||||||||||
| PRIME BRAIN GENETICS VACCINE VIRUS | |||||||||||||||||||
Mne32-006 | Aggregation and analysis of 25 years of prion disease natural history extracted from published literature | ||||||||||||||||||
| Quote: | Background and Objectives. Prion disease is an untreatable, typically rapidly progressive dementia. New drug candidates designed to lower prion protein are now entering clinical trials. To support future pivotal trials, we sought to assemble and analyze a public dataset of natural history data characterizing the symptomatic course of prion disease in order to provide a quantitative basis for modelling and rational trial design. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.07.26359973v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.07.26359973v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Leo MH Xu Daniel A Sprague Sonia M Vallabh Eric Vallabh Minikel, | ||||||||||||||||||
| GENETICS PSYCHOLOGY | |||||||||||||||||||
Mpy32-007 | PTSD is Associated with Advanced Epigenetic Age in 45,091 US Military Veterans | ||||||||||||||||||
| Quote: | PTSD was associated with advanced epigenetic aging in the largest study to date to evaluate this question. Effects were generally small in magnitude, though meaningful when considering the personal and healthcare system impact of advanced aging in the large population of VA users with PTSD. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.07.26359954v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.07.26359954v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Erika J Wolf Rui Zhang Xiang Zhao Mark Logue Brian Despard Phillip Ma Meghan Wilkinson Kelsey Serier Adam X Maihofer Kelly Harrington J. Michael Gaziano Alexandre Pereira Mark W Miller span classnlm-collab data-hwp-idcollab-1VA Million Veteran Program, | ||||||||||||||||||
| GENETICS PSYCHOLOGY | |||||||||||||||||||
Mpy32-019 | Perinatal risk factors, DNA methylation and the development of ADHD symptoms: a high-dimensional mediation analysis | ||||||||||||||||||
| Quote: | Conclusions In this first epigenome-wide mediation study of ADHD, we demonstrate a role of DNAm at birth in mediating the association of maternal smoking, birth weight and ADHD-related genetic variants with ADHD symptoms. However, lack of individual site-specific findings and the observational design limit causal biological interpretations. We therefore encourage further research of epigenetic pathways for these three risk factors. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.08.10.26360078v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.08.10.26360078v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Alexander Neumann Matthew Suderman Janine Felix Charlotte A.M. Cecil, | ||||||||||||||||||
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Javilk's Research Links Newsletter for Week 32 Updated 08/15/2026-01:24:35 AM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |