PRIME GUT MICROBIOME OBESITY
Mga32-013	Prophage Integration in relation to Body Mass Index-Related Gut Microbiome and Microbial Metabolism
	Quote:	we found that prophage carriage was associated with BMI-related microbial variations. In addition, prophage carriage was linked to altered patterns of association between bacterial host species and gut metabolic profiles. These findings suggest that prophages may contribute to variation in the bacterial hosts effect on BMI but the direction appears to be limited and species-dependent.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.08.11.26360202v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.08.11.26360202v1.full-text
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	Search Authors:	Zhuobing Peng Jonathan Thorsen Rebecca Vinding Frej Andreas Larsen Urvish Trivedi Sren Srensen Jakob Stokholm Dennis Sandris Nielsen Shiraz A. Shah Morten Arendt Rasmussen,
GUT MICROBIOME
Mga32-015	Microbial guild architecture transduces multi-component botanical inputs into multi-receptor-mediated gut motility restoration
	Quote:	Through gnotobiotic transplantation and receptor antagonism, we demonstrate that lithocholic acid and propionic acid restore gut motility via concurrent engagement of Takeda G protein-coupled receptor 5 (TGR5) and G-protein coupled receptor 43 (GPR43). These findings identify microbial guild architecture as a function-resolved signal-transducing layer that converts multi- component botanical intervention into multi-receptor-mediated gut motility restoration, reframing the gut microbiome from a compositional system into a structural transducer between complex environmental inputs and host physiology.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.08.08.26359996v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.08.08.26359996v1.full-text
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	Search Authors:	Ziwan Ning Guojun Wu Jingyuan Luo Yunlyu Li Yaqi Li Jingchun Shi Wenyu Fang Wing Lam Wendy To Shifa Ruan Yujuan Zhou Sen Chow Jialing Zhang Xuanting Jiang Tao Wang Hetong Gao Shujun Xu Baohua Li Min Zhuang Ping Zheng Lin Zhu Chengyuan Lin Qin Liu Chun-Su Yuan Yan Y. Lam Lixiang Zhai Liping Zhao Zhaoxiang Bian,
GUT IMMUNE
Mga32-016	A Gut-Specific Bispecific Combining MAdCAM-1 Blockade and IL-22 Signaling to Halt T-Cell Inflammation and Promote Mucosal Restoration
	Quote:	Inflammatory bowel disease (IBD) is a heterogeneous chronic disease driven by dysregulated mucosal immunity and impaired epithelial barrier function.... On the epithelial side, the IL-22 cargo induces robust signaling in epithelial cells, promoting the expression of IL-22 response genes associated with antimicrobial defense, mucosal homeostasis, as well as IL-10 and CXCL1 expression. This effect contributes to immune cell trafficking to the intestinal mucosa. Together, this bispecific provides a localized dual-mechanism strategy for restoring intestinal immune homeostasis.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.08.07.26359969v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.08.07.26359969v1.full-text
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	Search Authors:	Juan Diego Sanchez Vasquez Amanda Sparkes Navin Asokumar Jaclyn C. Law Jean Garipy,

Javilk's Research Links Newsletter for Week 32
Updated 08/15/2026-01:24:35 AM
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Mga32-013

Prophage Integration in relation to Body Mass Index-Related Gut Microbiome and Microbial Metabolism

Mga32-015

Microbial guild architecture transduces multi-component botanical inputs into multi-receptor-mediated gut motility restoration

Mga32-016

A Gut-Specific Bispecific Combining MAdCAM-1 Blockade and IL-22 Signaling to Halt T-Cell Inflammation and Promote Mucosal Restoration