Research
Topics:
INDEX
AI-chat 2
MCS 1
PRIME 35
aging 8
brain 8
cancer 11
catastrophy 1
climate 3
cognition 4
covid-19 3
crime 7
culture 2
diabetes 3
diagnostics 2
drugs 2
economy 1
election 3
energy 1
exercise 3
gender 1
genetics 5
gut 3
heart 6
humor 1
immune 2
lyme 1
microbiome 3
nutrition 2
obesity 2
pain 1
physical 1
politics 6
pollution 1
psychology 3
quantum 1
reproduction 2
rights 1
soc-media
space 1
stress 1
tech 3
virus 1
 
Scanned: 1369
Evaluated: 235
Selected: 64

 
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Bcb33-002

Modulation of the sensitivity to ruxolitinib-mediated JAK2 inhibition by mutationally activated SHP2 exhibits cell context dependency in pre-clinical models of myeloproliferative neoplasms

Article: https://www.biorxiv.org/content/10.64898/2026.08.19.744423v1
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Search Authors: Tegan M Rowsell Garima Pandey Lucia Mazzacurati Narmin E Amin Gary W Reuther, 
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Bcb33-003

MYC-MIZ1 Complexes at Enhancers Tune Neuroendocrine Identity of Small Cell Lung Cancer

Article: https://www.biorxiv.org/content/10.64898/2026.08.19.745709v1
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Search Authors: Lisa M. Froehlich Hannah L. Tumbrink Bikash Adhikari Margarita Rempe Jenny Ostendorp Paula Zickler Michaela Hoehne-Wiechmann Alena Heimsoeth Yichun Tang Stefanie Lennartz Ayla Schwaebe Lisa Werr Matthias Fischer Alexander Quaas Holger Gruell Katia Garbert Daniela Morgenthaler Marian Touet Johannes A. Hildebrand Oliver Weigert Filippo Beleggia Dimitrios Papadopoulos Elmar Wolf Johannes Braegelmann Julia Frede Robert Haensel-Hertsch Martin L. Sos, 
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Bcb33-004

The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells

Quote: By integrating a genetic model of cortactin knockdown-induced CTC senescence with single-cell multi-omic analyses, we revealed two distinct senescent CTC subpopulations marked by HES1 expression levels. These HES1low and HES1high subpopulations exhibited differential evolutionary trajectory dynamics and unique molecular and metabolic signatures, which were significantly correlated with adverse clinical outcome across several patient cohorts.
Article: https://www.biorxiv.org/content/10.64898/2026.08.19.745859v1
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Search Authors: Guanyin Huang Xiaolong Xu Binyu Zhang Mao Zhao Yixin Cheng Boxi Zhao Shuqian Zheng Xuefei Liu Songyan Yu Liuyang Wang Jianyang Hu Chunhao Long Yihuizhi Zhang Yuling Sheng Siyuan Xia Lin Zeng Hui Yang Hao Yu Jialing Liu Yi Lu Jian Zhang Weineng Feng Meng Xu Weinan Guo Xin Hong, 
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Bcb33-006

High regeneration-associated stress defines a distinct HCC subgroup with therapeutically exploitable vulnerabilities

Quote: These findings reveal a conceptual shift for researchers and trialists: ATRi efficacy is decoupled from replication fork dynamics and instead leverages mitotic fragility. Practically, the LIVRESS and its IHC surrogate marker (KPNA2) offer a scalable roadmap for physicians to improve patient stratification in ATRi-based precision oncology trials. While requiring prospective validation, these results pave the way toward biomarker-driven therapies for advanced HCC.
Article: https://www.biorxiv.org/content/10.64898/2026.08.19.745832v1
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Search Authors: Nina Desboeufs Peter Leary Chenhui Zhao Sarah Kollar Lap Kwan Chan Lara Planas-Paz Andre Fitsche Alexander Schmidt Fabiola Prutek Katja R Baumann Simone Schneebeli Susanne Dettwiler Federico Dona Reha Akpinar Luigi M Terracciano Salvatore Piscuoglio Luca Di Tommaso Kim Wild Laura Summermatter Adrian Kobe Gilbert D Puippe Anne-Laure Leblond Katharina Endhardt Charlotte K Y Ng Sandro Nuciforo Markus H Heim Ralph Fritsch Chantal Pauli Andreas E Kremer Massimo Lopes Achim Weber, 
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Bcb33-007

Tumor context determines ARID1A effects on gastric cancer immunity

Article: https://www.biorxiv.org/content/10.64898/2026.08.18.745460v1
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Search Authors: Shu Xiao Ryan T. Heslin Morgan F. Pettigrew John D. Karalis Nafeesah Fatimah Shao-Po Huang Verena Cao Esther Burns Lynn Y. Kwon Ibrahim Nassour Skylar L. Nahi Hsien-Tsung Lai Changjin Hong Tae Hyun Hwang Isaac S. Chan Suntrea T.G. Hammer Hao Zhu Sam C. Wang, 
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Bcb33-011

Intracranial Targeting of Cholesterol Processing Reveals a Therapeutic Vulnerability that Reprograms Glioblastoma and Promotes Antitumor Immunity

Quote: gle cell RNA sequencing revealed activation of regeneration and plasticity programs, accompanied by immune microenvironment remodeling and enhanced inflammatory signaling. Importantly, syngeneic models preserved immune cell composition, supporting future integration with immunotherapeutic strategies. Together, these findings establish cholesterol dysregulation induced metabolic collapse as a promising therapeutic approach for GBM.
Article: https://www.biorxiv.org/content/10.64898/2026.08.18.745568v1
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Search Authors: Maria Jose Ulloa-Navas Rachel Melanie Whitehead Vanessa Kay Jones Loizos Michaelides Mieu M Brooks Aleeshba N Basil Raquel Morales-Gallel Cristina Gomez-Palmero Graciela Abril Reynaga-Macias Jesus Emiliano Sanchez-Garavito Brianna Tapia-Dierking Asha A Nair Juan Pablo Navarro Garcia de Llano Paula Schiapparelli Ian Dryden Steven S Rosenfeld Victoria E Clark Haidong Dong Loic Pierre Deleyrolle Hong Qin Vicente Herranz-Perez Yingxue Ren Jose Manuel Garcia-Verdugo Alfredo Quinones-Hinojosa, 
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Mpt33-003

Diagnostic accuracy of image-guided fine needle aspiration cytology in diagnosis of lung tumors

Quote: Conclusion and implications Image-guided FNAC is an excellent diagnostic accuracy tool which possess higher level of concordance with biopsy in evaluating lung masses.
Abstract: https://www.medrxiv.org/content/10.64898/2026.08.17.26360531v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.08.17.26360531v1.full-text
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Search Authors: Bishwobandhu Bhandari Mamata Tiwari Shital Adhikari Anuradha Khanal Nabin Bohara Chettri Shikha Pandey, 
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Mur33-002

Cost Minimisation and Threshold Analysis of Anatomical Endoscopic Enucleation of the Prostate

Abstract: https://www.medrxiv.org/content/10.64898/2026.08.15.26360519v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.08.15.26360519v1.full-text
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Search Authors: Julene Ong Rachel Lau Kit Mun Chow Daanesh Huned Roxanne Teo Han Jie Lee Ee Jean Lim Edwin Aslim Yong Wei Lim Kelven Chen Yi Quan Tan Joon Jae Park Joshua Tung, 
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Sd332-013

Scientists Uncover the Hidden Nerve Network Fueling Breast Cancer

Quote: Researchers have uncovered a surprising way triple-negative breast cancer may turn the body against itself. Tumors appear to recruit macrophagesimmune cells normally involved in healing and fighting infectionand use them to release a protein called BDNF that draws nerves into the tumor. Those nerves may then help the cancer grow, resist treatment, and potentially spread.
Article: https://www.sciencedaily.com//releases/2026/08/260814011038.htm
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Sd334-038

Scientists Turn Probiotic Bacteria Into Tiny Drug Factories for Pancreatic Cancer

Quote: In animal models, the therapy slowed the growth of pancreatic tumors by selectively activating T cells that fight cancer. Its effects became even stronger when researchers combined it with chemotherapy, radiotherapy or immunotherapy. The findings suggest that BifidoSumIL-2 could eventually provide a new way to improve how pancreatic tumors respond to treatment.
Article: https://www.sciencedaily.com//releases/2026/08/260816044830.htm
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Sd334-039

Breast Cancer Is Surging Among Asian American Women " and Scientists Dont Know Why

Article: https://www.sciencedaily.com//releases/2026/08/260815064829.htm
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  Javilk's Research Links Newsletter for Week 33
Updated 08/22/2026-02:37:36 AM
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