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Scanned: 2073 Evaluated: 266 Selected: 60 |
| COVID-19 GENETICS | ||||||||
Bbc36-006 | Cathepsin K Mediates the Formation of Potential Rheumatoid Arthritis-Relevant Cis- and Trans-Spliced Peptides Compatible With HLA-DR4 Presentation | |||||||
| Quote: | Rheumatoid arthritis (RA) is characterized by a loss of immunological tolerance to synovial self-proteins, yet the initial triggers generating novel neo-antigens remain incompletely defined. Here, we demonstrate that human cathepsin K (hCatK), a key cysteine protease driving joint degradation in RA, catalyzes covalent cis- and trans- splicing of peptides from major RA-associated self-proteins and foreign antigens, including type II collagen, fibrinogen, and SARS-CoV-2 Spike protein. | |||||||
| Article: | https://www.biorxiv.org/content/10.64898/2026.09.06.749279v1 | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Olivier Hinse S. Yasin Tabatabaei Dakhili Lee Freiburger Eliot Mar Jason Rogalski Sriram Subramaniam Eddie A. James Leonard J. Foster Dieter Brmme, | |||||||
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Javilk's Research Links Newsletter for Week 36 Updated 09/15/2026-02:09:31 AM What interests you? What have you found? Tell me! Drop me a note at Javilk.com to subscribe or submit something. |