Research
Topics:
INDEX
AI-chat 3
MCS 2
PRIME 24
aging 16
brain 8
brainwave 2
cancer 11
climate 1
cognition 5
covid-19 2
culture 4
dental 1
diabetes 5
diagnostics 1
drugs 5
ears 1
exercise 1
eyes 1
gender 2
genetics 5
gut 3
heart 8
immune 9
language 1
lyme 1
microbiome 3
misc
music 1
nutrition 9
obesity 2
pain 2
physical 3
politics 2
pollution 2
practice 2
psychology 6
quantum 2
reproduction 1
rights 1
sleep 1
soc-media
tech 1
vaccine 1
war-confl
 
Scanned: 3107
Evaluated: 147
Selected: 74

 
    PRIME    BRAIN    COGNITION    IMMUNE   

Aaa37-1001

Vitamin D Improves Cognition

Comment: A compilation of studies showing better cognition, reduced risks of dementia and alzheimers in those with higher vitamin D levels in their blood.
Article: https://richardgoldberg.substack.com/p/vitamin-d-improves-cognition
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    HEART    IMMUNE   

Mdb37-002

ACTH-independent hypercortisolism across the cardiometabolic spectrum

Quote: Conclusions: In this prospective study, the prevalence of ACTH-independent hypercortisolism paralleled the burden of cardiometabolic risk features. ACTH-independent hypercortisolism was associated with greater ACTH-stimulable cortisol production, identifying a unique biochemical phenotype. These findings reveal new insights into cortisol pathophysiology as a function of ACTH and cardiometabolic risk profiles.
Abstract: https://www.medrxiv.org/content/10.64898/2026.09.11.26362842v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.09.11.26362842v1.full-text
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Search Authors: Andrew J Newman Sanan Mahrokhian Isabelle Hanna Cheng-Hsuan Tsai Stefanie Parisien-La Salle Richard J. Auchus Jenifer M Brown Anand Vaidya, 
    IMMUNE    PSYCHOLOGY   

Mim37-003

Trajectory of Hyper IgE complications

Quote: Conclusions As the number of adults with hyper IgE syndrome increases our awareness of late onset complications is important. Aspergillus and pneumatoceles were less common than seen in some other cohorts. However, the significant rate of psychosis will represent a significant challenge for clinicians.
Abstract: https://www.medrxiv.org/content/10.64898/2026.09.11.26362846v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.09.11.26362846v1.full-text
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Search Authors: Asteria Mao Rui Xiao Kathleen E Sullivan Ramsay Fuleihan Charlotte Cunningham-Rundles Jennifer Puck Rebecca Marsh Roshini Abraham Luigi Daniele Notarangelo Vaibhavi Vichare span classnlm-collab data-hwp-idcollab-1USIDNET Network members, 
    PRIME    IMMUNE   

Mim37-004

Aspergillus and Candida in primary and secondary immunodeficiencies in USIDNET

Quote: Conclusions Candida and aspergillus are generally considered sentinel infections for myeloid disorders and T cell disorders. However, we found these infections associated with a broad range of inborn errors of immunity. This suggests that diagnostic testing should be broadened when facing patients with these infections.
Comment: It does not take immune deficits to get Candida Overgrowth. A diet rich in sugars as well as the wrong antibiotics, can do it just as well, even worse than immune deficits. An eye antibotic did that to me, nearly killing me in the 1980's. Dr. Crook wrote that many of the juvenile delenquents he treated exhibited mild candida overgrowth symptoms, and curing them of that also markedly reduced their rebeliousness.
Abstract: https://www.medrxiv.org/content/10.64898/2026.09.11.26362658v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.09.11.26362658v1.full-text
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Search Authors: Samantha Y Starkey span classnlm-collab data-hwp-idcollab-1USIDNET Consortium Kathleen E Sullivan, 
    GENETICS    IMMUNE   

Mim37-013

Defining the Genetic and Phenotypic Landscape of Primary Immune Regulatory Disorders Using the ClinGen Validation Framework

Quote: Conclusion: The PIRD-GCEP framework provides validated gene-disease classifications and identifies three distinct phenotypic clusters, facilitating improved diagnosis while revealing genes requiring further investigation to confirm their role in immune regulatory disorders.
Abstract: https://www.medrxiv.org/content/10.64898/2026.09.11.26362285v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.09.11.26362285v1.full-text
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Search Authors: Benjamin D. Solomon Justyne Ross Eleanor P. Fensterle Rasha S. Soliman Michelle K. Paczosa Alison Brittain Elizabeth M. Forbes Olga F. Sarmento Ivana Stojkic Shifaa Alkotob Jahnavi Aluri Jorge Diogo Da Silva Ana Rita Soares Monica Sulit Anita Chandra Fabian Hauck Stephen Jolles Paul J. Maglione Harry Lesmana Craig D. Platt Markus G. Seidel Andrew L. Snow Kathleen E. Sullivan Troy R. Torgerson Tiphanie P. Vogel Klaus Warnatz Kejian Zhang Purvesh Khatri Forum Raval Stuart G. Tangye Roshini S. Abraham, 
    COVID-19    GENETICS    IMMUNE   

Min37-003

ACE2 Polymorphisms rs2285666 and rs147311723 Are Clinically Relevant Variants in SARS-CoV-2 and Mycobacterium tuberculosis Co-infection.

Quote: These findings suggest that ACE2 genetic variability is associated with modulation of inflammatory responses and may contribute to organ-specific dysfunction in COVID-19 and TB across different populations. This highlights the potential role of host genetics in shaping disease severity and underscore the need for larger studies to validate these associations in diverse populations.
Abstract: https://www.medrxiv.org/content/10.64898/2026.09.11.26362837v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.09.11.26362837v1.full-text
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Search Authors: Mary Ngongang Kameni Assam Assam Jean Paul Eric Berenger Tchoupe Noubissi Toyim Albert Ange Maxime Tchoutang Maloba Franklin Tsague Voufo Svetlana Carel Kameni Georgette Njila Fuh Roger Neba Severin Donald Kamdem Palmer Masumbe Netongo, 
    MCS    IMMUNE   

Mkd37-015

Interpretable biomarker programs predict treatment response in lupus nephritis: patient-level validation across four regimens

Quote: A large share of late-stage clinical trial failures reflects not the underlying biology of the target but the composition of the enrolled population: trials recruit patients in whom the drug cannot work. Methods that identify likely responders before treatment therefore address a failure mode that better target selection alone cannot.
Abstract: https://www.medrxiv.org/content/10.64898/2026.09.13.26362948v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.09.13.26362948v1.full-text
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Search Authors: Prashant Kumar Abhinav Aurange Swapnil Keshari Shreyan Nalwad, 
    CANCER    IMMUNE   

Mpt37-014

Quantitative assessment of tumor immune microenvironment in context of HER2 expression in MIBC

Abstract: https://www.medrxiv.org/content/10.64898/2026.09.14.26363035v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.09.14.26363035v1.full-text
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Search Authors: Wei Du Shunsuke Koga Ranjitha Pratap Nair Rashmi Tondon Paul Zhang Raghunath Puthiyaveettil Lin Mei Priti Lal, 
    GENETICS    IMMUNE   

Sd375-014

Scientists Find an Immune false Alarm That May Drive Rapid Aging

Quote: Scientists have discovered that some severe genetic disorders linked to rapid aging may be driven not just by damaged DNA, but by the bodys overreaction to that damage. When broken DNA fragments leak into the wrong part of a cell, an immune sensor called cGAS can mistake them for signs of a viral infection, triggering chronic inflammation and even interfering with DNA repair
Article: https://www.sciencedaily.com//releases/2026/09/260915232130.htm
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  Javilk's Research Links Newsletter for Week 37
Updated 09/19/2026-02:54:36 AM
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