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Scanned: 1729
Evaluated: 336
Selected: 88

 
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    PRIME    PRIO    AGING    HEART   

Aef39-1006

Old hearts age backwards: transplanted organs adjust to hosts biological age

Quote: What happens to organs when they are transplanted? Hearts from young donors age rapidly in the bodies of older recipients, and older hearts are rejuvenated inside young people, according to a study1. The findings, posted on the preprint server bioRxiv and not yet peer reviewed, imply that replacement organs could be sourced from older people than they are at present....

"The remarkable thing is that we found exactly the same effects that we saw in the mice," says Poganik. The transplanted hearts had taken on the biological ages of their new hosts.

Article: https://www.nature.com/articles/d41586-026-03043-w
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See Also:
  • https://pubmed.ncbi.nlm.nih.gov/37500973/
  •     PRIME    PRIO    AGING    HEART   

    Aef39-1007

    Multi-omic rejuvenation and life span extension on exposure to youthful circulation

    Quote: Remarkably, this rejuvenation effect persisted even after 2 months of detachment. Transcriptomic and epigenomic profiles of anastomosed mice showed an intermediate phenotype between old and young, suggesting a global multi-omic rejuvenation effect. In addition, old HPB mice showed gene expression changes opposite to aging but akin to several life span-extending interventions. Altogether, we reveal that long-term HPB results in lasting epigenetic and transcriptome remodeling, culminating in the extension of life span and health span.
    Article: https://pubmed.ncbi.nlm.nih.gov/37500973/
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        AGING   

    Mep39-010

    Uncertainty redefines biological age

    Abstract: https://www.medrxiv.org/content/10.64898/2026.09.26.26364091v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.09.26.26364091v1.full-text
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    Search Authors: Yanjun Li Guoqing Feng Shouyi Yan Qi Huang Jin Jiang Zeyuan Pei Lyn Xuan Tay Keliang Li Zean Pan Zhichao Yuan Liangcai Gao John S. Ji Limei Ke Kuiying Gu Qian Di, 
        AGING    COGNITION    LANGUAGE   

    Mne39-004

    VoxNeuro: Leakage-Safe Parkinson Screening Support via Multi-View Grassmannian Speech Analysis

    Quote: Parkinsons disease (PD) affects speech production, motivating classification from repeated voice measurements. Record-wise evaluation can place recordings from the same participant in both training and test sets. We propose VoxNeuro, a novel subject-level framework combining Grassmann representations of repeated recordings with Euclidean mean-dispersion summaries through a provably positive-semidefinite kernel for support vector classification.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.09.27.26364114v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.09.27.26364114v1.full-text
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    Search Authors: Laiba Khan Manas Waghe, 
        PRIME    AGING    BRAIN    COGNITION   

    Mne39-005

    Tau-PET subtype modifies the association between plasma p-tau217 and memory in Alzheimers disease

    Quote: INTRODUCTION Plasma p-tau217 is associated with Alzheimers disease pathology and memory performance, but its implications for memory may depend on fibrillar tau topography. We examined whether tau-PET subtype modified the association between plasma p-tau217 and memory....

    DISCUSSION Tau-PET subtype modified the p-tau217memory association, suggesting that the cognitive implications of plasma p-tau217 may vary with tau topography.

    Abstract: https://www.medrxiv.org/content/10.64898/2026.09.25.26363629v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.09.25.26363629v1.full-text
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    Search Authors: Lukai Zheng Elham Ghanbarian Carlos Albarrn Morillo Kyan Younes Crystal M. Glover Laura A. Rabin Joshua D. Grill Michael Ewers S. Ahmad Sajjadi Ali Ezzati span classnlm-collab data-hwp-idcollab-1the Alzheimers Disease Neuroimaging Initiative (ADNI) span classnlm-collab data-hwp-idcollab-2the Health and Aging Brain (HABS-HD) Study Team span classnlm-collab data-hwp-idcollab-3the PREVENT-AD Research Group, 
        PRIME    AGING    GENETICS   

    Nih392-009

    DNA organization changes in Alzheimers disease, aging

    Quote: The scientists found DNA folding differences between cells obtained from the two groups. Distant parts of the DNA sequence were close to each other more often in cells from people with Alzheimers than in cells from people without Alzheimers. And neighboring parts of the sequence were close together less often.
    Article: https://nih.gov//news-events/nih-research-matters/dna-organization-changes-alzheimers-disease-aging
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        AGING    BRAIN   

    Sd391-011

    Scientists Found a Surprising Driver of Alzheimers Outside the Brain

    Quote: A new study from Washington University School of Medicine in St. Louis points to an unexpected source outside the brain. In experiments with mice, researchers found that T cells receive signals from lymph nodes that appear to prepare them to enter the brain and contribute to damage. When the scientists disrupted those signals, neurodegeneration was dramatically reduced.
    Article: https://www.sciencedaily.com//releases/2026/09/260925093150.htm
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        AGING    BRAIN    PSYCHOLOGY   

    Sd392-008

    Brain Scans Reveal Which Disorders Are Linked to Faster Brain Aging

    Quote: A massive MRI study found that Alzheimers disease, mild cognitive impairment, psychiatric disorders, and addiction are associated with distinct patterns of accelerated brain aging. The strongest effects appeared in Alzheimers and mild cognitive impairment, while ADHD and autism showed no significant overall difference.
    Article: https://www.sciencedaily.com//releases/2026/09/260927225038.htm
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        PRIME    AGING    BRAIN    NUTRITION   

    Sd395-010

    This Diet May Slow Brain Aging by 2.5 Years

    Quote: The Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay diet, or MIND for short, has previously been associated with better cognitive health, according to the researchers. The eating pattern emphasizes green leafy vegetables; other vegetables; berries; nuts; whole grains; fish; beans; olive oil; and poultry, along with moderate wine consumption. It also recommends limiting butter/margarine, cheese, red meat, pastries/sweets, and fried fast foods.
    Article: https://www.sciencedaily.com//releases/2026/09/260930225503.htm
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        AGING    GENETICS    HEART   

    Sd395-013

    Alzheimers Risk Gene APOE4 May Have a Reversible Weakness

    Quote: The Alzheimers risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing promising new targets for Alzheimers, Parkinsons, and other neurodegenerative
    Article: https://www.sciencedaily.com//releases/2026/09/260930225450.htm
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      Javilk's Research Links Newsletter for Week 39
    Updated 10/03/2026-03:08:04 AM
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