PRIME AGING BRAIN
Bne40-011	Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment
	Quote:	we show that the familial MAPT P301L mutation leads to neuronal network hyperexcitability. Imbalanced excitation and inhibition were attributable to neuronal subtype-specific tau pathology that was associated with different alterations of tau interactomes in excitatory versus inhibitory neurons
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.05.756807v1
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	Search Authors:	Changyi Ji Yunlu Zhu Hediye Erdjument-Bromage Soomin C Song Natalie Chang Amanda R Liu Alexa R Lee Olivia DeGulis David Schoppik Thomas A Neubert Hyung Don Ryoo Einar Sigurdsson,
PRIME AGING DIABETES
Bph40-010	Impaired glycolysis in bone underlies age-related bone loss in mice
	Quote:	Impaired glycolysis was associated with reduced protein levels of key glycolysis enzymes, and transcriptomics analyses revealed compensatory upregulation of glycolysis genes in aged bone. Metabolic intervention through long-term caloric restriction prevented age-related trabecular bone loss.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.06.738500v1
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	Search Authors:	Fangfang Song Tyler Marmo Won Dong Lee Jasmin Koehnken Sawall Chao Song Xueyang Liao Xing Ji Karthi Chellappa Melanie R McReynolds Joseph A Baur Christopher Thom Fanxin Long,
PRIME PRIO AGING CULTURE GENETICS
Mge40-015	A Multiethnic Analysis of DNA Methylation Reveals Links Between Alzheimers Disease and Metabolic Comorbidities
	Quote:	FROM FULL PDF: Adding to the complexity of the risk model is the fact that both AD and metabolic conditions disproportionately impact certain populations. For instance, MetS and T2D are roughly twice as common among Mexican American (MA) individuals, who are also 1.5 times more likely than non-Hispanic White (NHW) individuals to develop AD. In addition, genetic risk factors for AD also vary substantially by ethnicity.
	Comment:	Geography and Evolution created Nature as we know it. Evolution is a competition between idividuals and species for dominance, making it fundamentally racist. It is the goal of any society to blend the advantages of the individuals to cover the weakensses of the individuals so as to advance that society vs other soceties. This is true whether it is the social structure just discovered hidden in the communications of trees via roots in forests, or the very visible social cooperation in human mations. No society in recent history has done this better than the "meltimg pot" of America/ This was in large part via the use of the economic tokens we call money. Think about this: The most common example is our trust of the cash register operator regardless of their race or ethnic background, as they record the fixed prices of the goods we purchase. In contrast with cultures where the marketplace is ruled by the argument of haggling over prices, our Fixed-Price market culture and the enforced fairness of the cash register have done far more for racial equiality and trust than any group of advocates, laws, or religious tenants ever did.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364777v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364777v1.full-text
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	Search Authors:	Benjamin Landon Ann Abraham Daniel Tamara Fischer Nicole Phillips Robert Barber Austin Reynolds span classnlm-collab data-hwp-idcollab-1The Health and Aging Brain Study: Health Disparities (HABS-HD) Study Team,
AGING BRAIN
Mge40-017	GALC variants affect Glucocerebrosidase to Galactosylceramidase activity ratio
	Quote:	Objective: Genes within the lysosomal glycosphingolipid pathway, including GBA1 and GALC, are important genetic risk factors in Parkinsons disease (PD). We hypothesized that PD risk relates not only to individual enzyme effects but also to coordination between glucocerebrosidase (GCase) and galactosylceramidase (GalCase) activities, and examined how genetic variants influence their activity ratio.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364651v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364651v1.full-text
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	Search Authors:	Amirhossein Rajabi Vajargah Konstantin Senkevich Zhao Zhang Lang Liu Saeid Amiri Morvarid Ghamgosar Shahkhali Meron Teferra Camille Lacarriere-Keita Pablo Sardi Ming Sum Ruby Chiang Cheryl Waters Adil Harroud Roy Alcalay Thomas Durcan Edward A. Fon Ziv Gan-Or,
PRIME PRIO AGING NUTRITION
Ps402-016	Could Lithium Be Used To Treat Alzheimers Disease?
	Quote:	In 2011, researchers showed that in area of Japan with higher levels of lithium in the water, people actually lived longer. In 2017 a group in Texas found that in counties with higher lithium levels, people died less often of Alzheimers. In 2018 lithium was shown to enhance the clearance of amyloid-#946; (A#946;) which is commonly found in people with Alzheimers. And yet, there is no RDA for lithium. Like so many things that cant be patented and sold for profit, our government agencies are slow to get interested in cheap treatments.... The natural intake of lithium is between 0.5mg to 1mg per day, but in some parts of the world it reaches up to 5mg a day. Doses used to treat bipolar disorder are vastly higher as much as 100 to 200mg a day of elemental lithium for years on end. This is via a prescription for something like 1,000mg of lithium carbonate. There are sometimes side effects at these high doses that need monitoring (talk to your doctor, etc). The form of lithium that seemed most useful in this study was Lithium Orotate which is available over the counter in many countries
	Article:	https://principia-scientific.com/could-lithium-be-used-to-treat-alzheimers-disease/
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AGING BRAIN IMMUNE
Sd405-015	Drug Target Could Block Brain Inflammation Linked to Alzheimers and Parkinsons
	Quote:	The team found that P2X7 receptors promote the release of cytokines, proteins that help regulate inflammatory responses. When the researchers used a specific antagonist to block the receptor, the inflammatory response in human brain tissue dropped significantly.
	Article:	https://www.sciencedaily.com//releases/2026/10/261005071515.htm
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Javilk's Research Links Newsletter for Week 40
Updated 10/10/2026-01:10:19 AM
Back Issue Topic Map
What interests you? What have you found? Tell me!
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Bne40-011

Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment

Bph40-010

Impaired glycolysis in bone underlies age-related bone loss in mice

Mge40-015

A Multiethnic Analysis of DNA Methylation Reveals Links Between Alzheimers Disease and Metabolic Comorbidities

Mge40-017

GALC variants affect Glucocerebrosidase to Galactosylceramidase activity ratio

Ps402-016

Could Lithium Be Used To Treat Alzheimers Disease?

Sd405-015

Drug Target Could Block Brain Inflammation Linked to Alzheimers and Parkinsons