PRIME AGING BRAIN
Bne40-011	Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment
	Quote:	we show that the familial MAPT P301L mutation leads to neuronal network hyperexcitability. Imbalanced excitation and inhibition were attributable to neuronal subtype-specific tau pathology that was associated with different alterations of tau interactomes in excitatory versus inhibitory neurons
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.05.756807v1
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	Search Authors:	Changyi Ji Yunlu Zhu Hediye Erdjument-Bromage Soomin C Song Natalie Chang Amanda R Liu Alexa R Lee Olivia DeGulis David Schoppik Thomas A Neubert Hyung Don Ryoo Einar Sigurdsson,
AGING BRAIN
Mge40-017	GALC variants affect Glucocerebrosidase to Galactosylceramidase activity ratio
	Quote:	Objective: Genes within the lysosomal glycosphingolipid pathway, including GBA1 and GALC, are important genetic risk factors in Parkinsons disease (PD). We hypothesized that PD risk relates not only to individual enzyme effects but also to coordination between glucocerebrosidase (GCase) and galactosylceramidase (GalCase) activities, and examined how genetic variants influence their activity ratio.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364651v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364651v1.full-text
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	Search Authors:	Amirhossein Rajabi Vajargah Konstantin Senkevich Zhao Zhang Lang Liu Saeid Amiri Morvarid Ghamgosar Shahkhali Meron Teferra Camille Lacarriere-Keita Pablo Sardi Ming Sum Ruby Chiang Cheryl Waters Adil Harroud Roy Alcalay Thomas Durcan Edward A. Fon Ziv Gan-Or,
BRAIN COGNITION
Mpy40-016	Longitudinal trajectories of ADHD symptoms: relationships to early-childhood predictors and later outcomes
	Quote:	Conclusion: While several early risk factors were associated with ADHD symptoms initially, none robustly predicted symptom trajectories over time. However, increasing irritability and inattention were robustly associated with increased risk for new disorder onsets later in adolescence.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364348v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.10.05.26364348v1.full-text
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	Search Authors:	Emily Rounds Michael Kozlowski Shane McCormack Peter Ryabinin Elizabeth Nousen Jessica Tipsord Nathan Dieckmann Sarah Karalunas Megan Herting Stephen Faraone Molly Nikolas Joel Nigg Michael Mooney,
AGING BRAIN IMMUNE
Sd405-015	Drug Target Could Block Brain Inflammation Linked to Alzheimers and Parkinsons
	Quote:	The team found that P2X7 receptors promote the release of cytokines, proteins that help regulate inflammatory responses. When the researchers used a specific antagonist to block the receptor, the inflammatory response in human brain tissue dropped significantly.
	Article:	https://www.sciencedaily.com//releases/2026/10/261005071515.htm
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Javilk's Research Links Newsletter for Week 40
Updated 10/10/2026-01:10:19 AM
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Bne40-011

Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment

Mge40-017

GALC variants affect Glucocerebrosidase to Galactosylceramidase activity ratio

Mpy40-016

Longitudinal trajectories of ADHD symptoms: relationships to early-childhood predictors and later outcomes

Sd405-015

Drug Target Could Block Brain Inflammation Linked to Alzheimers and Parkinsons