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Mcr40-002

Myocardial Perfusion in Patients with Primary Mitral Regurgitation Due to Mitral Valve Prolapse

Quote: Conclusion: In patients with significant MR due to MVP, myocardial perfusion appears preserved despite LV volume overload. However, lower MPR in symptomatic patients suggests that microvascular dysfunction may emerge in a more advanced disease stage.
Abstract: https://www.medrxiv.org/content/10.64898/2026.10.04.26364711v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.10.04.26364711v1.full-text
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Search Authors: Klara Lodin Jannike Nickander Anne Wang Gottlieb Jacob Widaeus Lauge stergaard Lars H. Lund Peter Svenarud Magnus Daln Sara Tehrani Marcus Carlsson Bahira Shahim, 
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Mcr40-003

Beat-to-Beat Action Potential Duration Variability, Not Duration, Reflects -Adrenergic Stimulation-Induced Repolarization Instability

Quote: These results support APD variability as a more sensitive and mechanistically plausible marker of proarrhythmic risk than APD prolongation alone. Our findings suggest that QT interval variability may improve risk stratification and provide a more robust mechanistic foundation for drug safety evaluation.
Abstract: https://www.medrxiv.org/content/10.64898/2026.10.02.26364548v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.10.02.26364548v1.full-text
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Search Authors: Daisuke Sato Roshni Shetty Raffaele Coppini Eleonora Grandi, 
    PRIME    PRIO    HEART   

Mge40-009

Genetic support for an adverse effect of calcium channel blockers on the human thoracic aorta

Quote: Despite the widespread use of L-type calcium channel blockers (CCBs), recent observational and murine functional work has suggested a potential adverse effect of this medication class on the aorta.
Abstract: https://www.medrxiv.org/content/10.64898/2026.10.02.26364570v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.10.02.26364570v1.full-text
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Search Authors: Julia Horjus Sean J. Jurgens Connie R. Bezzina Nimrat Grewal, 
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Mop40-014

Four-State Hemodynamic Framework for Neovascular Age-Related Macular Degeneration: Mathematical Model Integrating Vascular Permeability, Lesion Transmural Pressure, Choroidal Excess Pressure, and Wall Stability

Quote: Conclusion Lesion transmural pressure due to high inflow left residual exudation even after permeability suppression with anti-VEGF. Fluid resolution on optical coherence tomography may not parallel a reduction in the rupture-hazard index, depending on wall stability.
Abstract: https://www.medrxiv.org/content/10.64898/2026.10.05.26364815v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.10.05.26364815v1.full-text
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Search Authors: Yasuo Yanagi Satoru Inoda Keiko Azuma Hidenori Takahashi Tatsuya Inoue Maiko Mayumura-Inoue Kazuaki Kadonosono, 
    PRIME    HEART    NUTRITION   

Sd405-038

Not All Trans Fats Are Bad, Major Review Finds

Quote: A large analysis of 22 studies found that the trans fats naturally present in dairy foods such as milk, butter, yogurt, and cheese do not appear to raise the risk of heart disease or type 2 diabetes. Unlike industrial trans fats from partially hydrogenated oils, dairy trans fats showed no meaningful harmful effects on blood fats in controlled trials
Article: https://www.sciencedaily.com//releases/2026/10/261006234505.htm
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  Javilk's Research Links Newsletter for Week 40
Updated 10/10/2026-01:10:19 AM
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