PRIME IMMUNE
Bim42-006	Systemic Autoimmunity Remodels Microbiota-Reactive CD4 T Cell Immunity
	Quote:	Here, we show that systemic autoimmunity drives the expansion, accumulation, and functional differentiation of microbiota-reactive CD4#8314; T cells. Using segmented filamentous bacteria tetramers, we identify antigen-defined microbiota-reactive CD4#8314; T cells that undergo systemic accumulation and Th1/Tfh polarization during disease. We further identify reactivation of intestinal dendritic cell trafficking as a mechanism linking systemic autoimmunity to the accumulation of microbiota-reactive CD4#8314; T cells in peripheral tissues.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.17.759871v1
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	Search Authors:	Maricielo J. Vaella-Alarcon Miki Kume Silvia R. Davila-Paico Luis F. Soto-Ugaldi Katherine S. Saldana-Morales Gillian L. McClennen Jin Din Samantha St. Jean Daniel F. Zegarra-Ruiz,
BRAIN EYES IMMUNE
Bim42-011	Innate Immune Dysregulation Precedes Clinical Onset in Neuromyelitis Optica
	Quote:	VirScan identified enhanced CMV-specific antibody reactivity following AQP4- IgG seroconversion, and network analyses revealed interactions between NMOSD-associated and CMV-derived proteins. Together, these findings establish a novel multi-hit model of NMOSD, with implications for understanding antibody-mediated autoimmunity more broadly.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.16.757427v1
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	Search Authors:	Leonie Muller-Jensen Debanjana Chakravarty Gianmarco Bellucci Yuan Ding Michelle Hughes Alejandro Mejia Garcia Carson E. Moseley Ravi Dandekar John W. Rose Lisa K. Peterson Ka-Ho Wong Bradley L. Demarest Noel Carlson David E. Horvat Keith Groshans Nathan Tagg Spencer R. Osbourn Sithembile L. Mabila Ruba Bou-Chahine Victor Wang M. Mateo Paz Soldan Sean J Pittock Bruce A. C. Cree Scott S. Zamvil Ari J. Green Adil Harroud Sergio E. Baranzini Michael R. Wilson Stacey L. Clardy Ahmed Abdelhak Tammy L. Smith,
PRIME IMMUNE VACCINE
Ps421-002	The Fraud That Launched the mRNA Vaccine Era
	Comment:	While some of his ideas may have merit, note the author is somewhat anti-vaccination.
	Article:	https://principia-scientific.com/the-fraud-that-launched-the-mrna-vaccine-era/
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CANCER IMMUNE
Sd421-003	Why Painful Arthritis Can Return Stronger After Cancer Treatment
	Article:	https://www.sciencedaily.com//releases/2026/10/261018205055.htm
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PRIME GUT IMMUNE MICROBIOME NUTRITION
Sd421-038	Scientists Tested 39 Sweeteners and Uncovered Surprising Gut Effects
	Quote:	In laboratory experiments involving 39 sweeteners and 25 species of gut bacteria, researchers found that roughly three-quarters of the sweeteners altered the growth of at least one bacterial species. Some slowed or completely stopped the growth of microbes associated with a healthy digestive system. One combination stood out in particular. When the sweetener isosteviol was paired with the antidepressant duloxetine, it strongly suppressed two important gut bacteria involved in maintaining digestive health and regulating blood sugar. The combination also disrupted the balance of a simulated gut microbiome and produced changes that could have implications for inflammation and immune responses.
	Article:	https://www.sciencedaily.com//releases/2026/10/261016081103.htm
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Javilk's Research Links Newsletter for Week 42
Updated 10/24/2026-02:39:34 AM
Back Issue Topic Map
What interests you? What have you found? Tell me!
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Bim42-006

Systemic Autoimmunity Remodels Microbiota-Reactive CD4 T Cell Immunity

Bim42-011

Innate Immune Dysregulation Precedes Clinical Onset in Neuromyelitis Optica

Ps421-002

The Fraud That Launched the mRNA Vaccine Era

Sd421-003

Why Painful Arthritis Can Return Stronger After Cancer Treatment

Sd421-038

Scientists Tested 39 Sweeteners and Uncovered Surprising Gut Effects