Research
Topics:

INDEX

PRIME 15

gut 1

tech 2

Scanned: 3718
Evaluated: 194
Selected: 41

Back Issue Map

CANCER GENETICS
Bcb43-021	Transient Splicing-Associated Isoform Remodeling Defines Early MAPKi Resistance Adaptation in Melanoma
	Quote:	Notably, most genes undergoing differential transcript usage showed no corresponding change in total gene expression, and genes with isoform-level changes more strongly highlighted MAPKi resistance-associated pathways, including PI3K/AKT/mTOR and receptor tyrosine kinase signaling. Further, classifiers trained on cell-line transcript-usage features identified the adaptive state more accurately than gene-expression-based models in independent PDX and patient datasets. Interestingly, MAPKi-associated isoform changes recapitulated melanoblast-associated developmental splicing programs and were linked to a few key splicing regulators. Together, these findings identify an underappreciated regulatory layer connecting drug tolerance, developmental plasticity, and acquired resistance.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.26.761932v1
	Search Similar:	Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho
	Search Authors:	Sumit Mukherjee Arashdeep Singh Sumeet Patiyal Hyunjeong Joo Hyungsoo Kim Lipika R. Pal Kun Wang Chi-Ping Day Zeev A Ronai Eytan Ruppin Sridhar Hannenhalli,
BRAIN GENETICS
Bge43-020	Glial cells gate small RNA transport from germline to brain during transgenerational epigenetic inheritance of behavior
	Quote:	ID-1 mediates uptake of germline-derived RNA, followed by transcytosis to a neighboring sensory neuron, where the P11 target gene maco-1 is silenced. This glial "filter", which uses highly conserved molecular components to transcytose RNAs to neurons, reveals a general mechanism for gating small RNA access to the nervous system, paralleling the mammalian blood-brain barrier.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.24.761599v1
	Search Similar:	Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho
	Search Authors:	Abigail K. Brown Xinbei Li Rachel Kaletsky Renee Seto Katherine E Novak Liyang Sun Coleen T. Murphy,
AGING GENETICS
Sd432-014	Low-Dose Aspirin Linked to 70 Lower Dementia Risk, but Theres a Catch
	Quote:	A new analysis from Monash University suggests that low-dose aspirin may be linked to a dramatically lower risk of dementia in older adults with certain genetic characteristics. Researchers found that people with a specific genetic profile who took aspirin had a 70 percent lower relative risk of developing dementia, raising the possibility that genetic testing could eventually help identify people who might benefit from preventive treatments.
	Article:	https://www.sciencedaily.com//releases/2026/10/261024222026.htm
	Search Similar:	Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho

Javilk's Research Links Newsletter for Week 43
Updated 10/31/2026-02:16:20 AM
Back Issue Topic Map
What interests you? What have you found? Tell me!
Drop me a note at Javilk.com to subscribe or submit something.