MISC
Bcb43-003	Molecular glue degraders of CK1 remodel lysosomes and limit ferroptosis in glioblastoma stem-like cells
	Quote:	Acute CK1#945; degradation efficiently recapitulated lysosomal remodeling and impaired tumorsphere formation in GSCs. While CK1#945;-targeted MGDs did not sensitize GSCs to lysosomal membrane permeabilization induced by L-leucyl-L-leucine methyl ester (LLOMe), they protected from GPX4 inhibitor-induced ferroptosis. Together, these findings identify CK1#945; as a regulator of lysosomal fitness and ferroptotic sensitivity, suggesting a connection between CK1#945;-dependent lysosome remodeling and associated cell death pathways.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.23.760392v1
	Search Similar:	Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho
	Search Authors:	Jane Jardine Margaux Le Guyon Kilian Trillet Audrey Lacquemant Isabelle Verdu Talha Sagheer Laura Merlet Rosalie Moreau Gwennan Andre-Gregoire Mathilde Kerherve Francois Guillonneau Guillaume Bastiat Julie Gavard Nicolas Bidere,

Javilk's Research Links Newsletter for Week 43
Updated 10/31/2026-02:16:20 AM
Back Issue Topic Map
What interests you? What have you found? Tell me!
Drop me a note at Javilk.com to subscribe or submit something.

Bcb43-003

Molecular glue degraders of CK1 remodel lysosomes and limit ferroptosis in glioblastoma stem-like cells