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Bcb44-002

AMD1-driven MTA production sustains chemoresistance by rewiring PMN-MDSC immunosuppression

Quote: Our findings identify MTA as an important metabolic link between chemoresistant tumor cells and PMN-MDSCs to sustain immunosuppression and therapeutic resistance. Targeting AMD1-dependent MTA production represents a valuable strategy for overcoming chemo-immunotherapy resistance.
Article: https://www.biorxiv.org/content/10.64898/2026.11.02.763561v1
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Search Authors: Yinan Wang Wen Qiao Bin Yu Cegui Hu Hao Li Hanjun Li Rongyu Zhang Luying Li Peng Li Nannan Sha Shijia Bao Shanni Guo Guiying Wei Dongxi Xiang Jun Gui, 
    CANCER    POLLUTION   

Bcb44-003

KaryoTap-based scDNA seq assessment of aneuploidy induction by hydroquinone in hematopoietic stem cells

Quote: These findings do not support a substantial, reproducible increase in whole-chromosome aneuploidy after HQ exposure under the conditions tested. They are consistent with a model in which benzene exposure favors the expansion of pre-existing monosomy 7 clones, although this possibility requires direct testing.
Article: https://www.biorxiv.org/content/10.64898/2026.11.02.763824v1
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Search Authors: Maria Trifas Stephanie Aronson Fabio Alfieri Manjunatha Kogenaru Rachel Kim Teresa Davoli, 
    CANCER   

Bcb44-005

Endogenous PROM1 activation redistributes liver cancer cells along a preexisting differentiation axis

Article: https://www.biorxiv.org/content/10.64898/2026.11.01.763386v1
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Search Authors: Tom Schneider Kota Kaneko Marion Vogl Kirsten Utpatel Alexander Immel Daniela Hirsch Chiara Raggi Elena Spinola Lasso Matthias Evert Gen-Sheng Feng Diego F. Calvisi Alexander Scheiter, 
    CANCER    REPRODUCTION   

Bcb44-007

ANABOLIC FAILURE, NOT CATABOLIC ACTIVATION, UNDERLIES GLYCOGEN DEPLETION IN CERVICAL CARCINOGENESIS: A MULTI-COHORT TRANSCRIPTOMIC ANALYSIS

Quote: Conclusions. Glycogen depletion in cervical carcinogenesis reflects failure of a tissue-restricted synthetic axis, GYS2 and PPP1R3C, within a collapsing squamous differentiation program, not catabolic activation. Measuring all four candidate mechanisms on one scale in the same specimen is what allows the catabolic explanation to be excluded rather than merely left untested. The pattern holds across two array chemistries and three specimen preparations, including the exfoliated cytology that screening already collects, and the synthesis and differentiation modules together are the molecular counterpart of what iodine staining reports. These are transcript-level findings and define no clinical threshold.
Article: https://www.biorxiv.org/content/10.64898/2026.11.02.763436v1
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Search Authors: Oyedele Oyewumi Ajayi Efosa Bolaji Odigie Samson Oluwaseyi Adesite Theophilus Erameh Anietie Michael Archibong Uchechukwu Brian Eziagu, 
    PRIME    AGING    CANCER    GENETICS   

Bcb44-009

Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication

Quote: Together, these findings show that epigenetic trajectories during early tumor development, are rooted in baseline, age-dependent drivers of epigenetic alterations, and that oncogenic signaling acts primarily by selecting and expanding clones bearing pre-existing, age-associated epigenetic drift rather than instructing new methylation. Our findings have implications for how promoter methylation is interpreted as a cancer biomarker and for identifying upstream aging-associated processes as targets for early intervention.
Article: https://www.biorxiv.org/content/10.64898/2026.10.30.763235v1
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Search Authors: Hari Easwaran Sara-Jayne Thursby Nibedita Patel Zhicheng Jin Jacob Blum Shilpa Bisht Yong Tao Yuba Bhandari Daniel Petkovich Hisashi Ro Lijing Yang Jeff (Tza-Huei) R Wang Thomas Pisanic span classnlm-suffixII Stephen Bruce Baylin, 
    CANCER    GENETICS   

Bgn44-018

Epigenetic reprogramming by promoter hypomethylation is linked to aberrant gene expression and transcriptomic plasticity in colorectal cancer

Article: https://www.biorxiv.org/content/10.64898/2026.11.04.763625v1
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Search Authors: Lus Nunes Ina A. Eilertsen Rita Pinto Hege M. Vedeld Ingrid M. Bolstad Usman Saeed Ole H. Sjo Sheraz Yaqub Arild Nesbakken Kushtrim Kryeziu Guro E. Lind Ragnhild A. Lothe Anita Sveen, 
    CANCER   

Bpa44-002

Pathology foundation-model embeddings reveal a morphological landscape of breast lesions beyond diagnostic categories

Quote: Conclusions: Leveraging morphology-based foundation-model embeddings, we defined a morphologic state space across breast lesion categories, allowing nuanced positioning of breast lesions along a pathobiological continuum associated with tumor development. Our approaches pave the way for extracting biologically and clinically relevant information from routine histopathology to guide molecular testing, individualized risk assessment, and cost-efficient clinicopathological decision-making.
Article: https://www.biorxiv.org/content/10.64898/2026.11.02.760689v1
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Search Authors: Yuki Muroyama Eichi Takaya Takashi Suzuki, 
    PRIME    CANCER    GUT   

Sd430-004

Scientists Finally Discover How a Common Gut Bacterium Can Trigger Colon Cancer

Quote: The bacterium, Bacteroides fragilis, produces a toxin that damages the colons protective lining, triggers chronic inflammation, and promotes tumor formation.
Article: https://www.sciencedaily.com//releases/2026/10/261031012912.htm
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Sd443-003

Scientists Trick Cancer Cells Into Making the Drugs That Kill Them

Quote: Scientists have developed a promising new cancer-fighting strategy that uses carbon monoxide naturally produced by tumor cells to manufacture powerful drugs inside the cancer cells themselves.
Article: https://www.sciencedaily.com//releases/2026/11/261101010552.htm
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    BRAIN    CANCER    TECH   

Sd443-019

Scientists Use Sound Waves to Deliver a New Attack on Deadly Brain Cancer

Quote: The research team, led by UVAs Roger Abounader, MD, PhD, identified tiny genetic molecules known as "microRNAs" that can interfere with several genes responsible for the development and growth of glioblastoma. To deliver these molecules into the brain, the researchers combined specialized nanoparticles, focused ultrasound and microscopic bubbles. Together, these technologies offer a way to temporarily cross the brains protective barrier, which normally prevents many treatments from reaching brain tumors and other neurological conditions.
Article: https://www.sciencedaily.com//releases/2026/10/261030003017.htm
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See Also:
  • https://www.jci.org/articles/view/195639
    •     PRIME    CANCER    NUTRITION   

    Sd443-040

    Even Moderate Drinking Linked to Cancer and Early Death, Major Study Finds

    Quote: The findings suggest that alcohols risks begin at relatively low levels of consumption and increase as people drink more. "This study provides the most comprehensive U.S. estimates to date of lifetime risks of alcohol-attributable mortality and morbidity, showing that even moderate levels of consumption increase the risk of premature death and disability," said study co-author Katherine M. Keyes, PhD, professor of Epidemiology at Columbia University Mailman School of Public Health.
    Article: https://www.sciencedaily.com//releases/2026/10/261031221159.htm
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        PRIME    CANCER    POLLUTION   

    Zze44-1056

    New Study Finds Paper Straws Worse For The Environment Than Plastic

    Quote: South Koreas Ministry of Climate, Energy and Environment, evaluated four types of straws conventional plastic, paper, biodegradable plastic, and bio-based polyethylene and their life-cycles in 16 different environmental categories. Conventional plastic straws had the smallest environmental impact in 10 of the 16 categories, including climate change, human toxicity, particulate matter, and acidification. Paper straws, meanwhile, had 6.33 times the carcinogenic impact of standard plastic straws, plus twice as much impact on acidifying the environment, according to the study. Meanwhile, biodegradable plastic straws had 3.34 times the carcinogenic impact and 1.98 times the acidification impact of conventional plastic straws, the study found. As for bio-based polyethylene straws made from renewable materials like sugarcane they produced 16 times the carcinogenic impact of conventional plastic straws, and six times the acidification damage, a measure of changes in ocean and soil pH.
    Article: https://principia-scientific.com/new-study-finds-paper-straws-worse-for-the-environment-than-plastic/
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      Javilk's Research Links Newsletter for Week 44
    Updated 11/06/2026-10:26:45 PM
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