GENETICS SLEEP
Mge01-024	Polygenic risk scores and Mendelian randomization reveal circadian genetic contributions to idiopathic hypersomnia
	Quote:	PRS analysis identified significant associations between IH and sleep traits such as eveningness and daytime napping, with notably large effect sizes. Importantly, MR analysis further suggested a causal role for eveningness in IH pathogenesis. These findings highlight distinct genetic subtypes within IH and reinforce the relevance of circadian misalignment in its pathophysiology.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.06.26343504v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.06.26343504v1.full-text
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	Search Authors:	Taku Miyagawa Mihoko Shimada Kotomi Tanida Nozomu Kotorii Takao Kato Tatayu Kotorii Yu Ariyoshi Hiroshi Hiejima Motohiro Ozone Naohisa Uchimura Azusa Ikegami Kazuhiko Kume Takashi Kanbayashi Aya Imanishi Yuichi Kamei Akiko Hida Yamato Wada Kenji Kuroda Masayuki Miyamoto Koichi Hirata Masanori Takami Naoto Yamada Masako Okawa Naoto Omata Hideaki Kondo Tohru Kodama Yuichi Inoue Kazuo Mishima Katsushi Tokunaga Makoto Honda,

Updated weekly. 01/09/2026-11:01:09 PM
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