| Research Topics: |
| INDEX |
| AI-chat 1 |
| PRIME 18 |
| aging 9 |
| body 2 |
| brain 10 |
| cancer 11 |
| censorship 1 |
| cognition 4 |
| covid-19 1 |
| culture 2 |
| dental 1 |
| diabetes 1 |
| gender 2 |
| genetics 2 |
| heart 8 |
| immune 5 |
| kidneys 6 |
| language 1 |
| lungs 7 |
| metabolism 3 |
| microbiome 3 |
| nutrition 6 |
| obesity 2 |
| pain 2 |
| physical 2 |
| politics 2 |
| pollution 2 |
| practice 1 |
| privacy 2 |
| psychology 4 |
| reproduction 1 |
| rights 1 |
| sleep 3 |
| tech 1 |
| virus 2 |
| war-confl |
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Scanned: 2759 Evaluated: 288 Selected: 68 |
| PRIME AGING BRAIN | |||||||||||||||||||
Mep03-040 | Accelerated multi-organ proteomic aging is detectable decades before dementia onset | ||||||||||||||||||
| Quote: | Among these is tumor necrosis factor receptor superfamily member 1B TNFRSF1B, causally implicated in the accelerated pace of brain, immune, muscle, and pancreas aging. Two other proteins associated with pace of brain aging, GM2 ganglioside activator GM2A and limbic system-associated membrane protein LSAMP, showed putative causal roles in multiple neurologic diseases. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.16.26344299v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.16.26344299v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Fangyu Liu Wenyu Zhou Aditya Surapaneni Jingsha Chen Cassandra Joynes Pascal Schlosser Zulema Rodriguez-Hernandez Endre Sebestyn Hamilton Se-Hwee Oh Tony Wyss-Coray Gabriela T. Gomez Michael R. Duggan Anna Prizment Sanaz Sedaghat Shuo Wang Michael E. Griswold Josef Coresh Morgan E. Grams Keenan A. Walker, | ||||||||||||||||||
| AGING | |||||||||||||||||||
Mgr03-022 | Pharmacotherapy for Alzheimers Disease and Dementias in Long-Term Care: A Real-World EHR Study | ||||||||||||||||||
| Quote: | Conclusions and Implications More than one-quarter of residents with ADRD remain untreated with guideline-recommended pharmacotherapy, and treatment varied significantly by non-clinical predictors. These findings underscore the need to investigate and understand possible treatment disparities, optimize polypharmacy management, and discover new ADRD treatments, as current options are often ineffective with many side effects. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.16.25342403v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.16.25342403v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Tyler M. Saumur Huda Ashraf Katherine E. Mathers Brittin L. Wagner, | ||||||||||||||||||
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| AGING BRAIN | |||||||||||||||||||
Mne03-004 | Alpha-synuclein propagation trajectories in a population-based postmortem cohort | ||||||||||||||||||
| Quote: | we show that the spatial extent of #945;-synuclein pathology contributes to cognitive impairment independently of comorbid Alzheimers disease or transactive response DNA-binding protein 43 TDP-43 pathology. Together, these results provide a framework for patient stratification and for linking #945;-synuclein propagation patterns to clinical trajectories from prodromal to late stages. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.13.26343943v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.13.26343943v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Parsa Khalafi Jacob W Vogel Per Borghammer Anna Raunio Ville Kivist Sara Savola Eloise H Kok Elizaveta Mikhailenko Liisa Myllykangas Alain Dagher, | ||||||||||||||||||
| PRIME AGING BRAIN SLEEP | |||||||||||||||||||
Mne03-012 | Sleep-like slow waves during resting-state: a promising EEG biomarker of amyloid and neurodegeneration in preclinical Alzheimer disease | ||||||||||||||||||
| Quote: | DISCUSSION Wake SW represent promising early EEG biomarkers for AD pathology and amyloid conversion, facilitating risk stratification before cognitive decline onset. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.15.26344195v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.15.26344195v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Pierre Champetier Claudia Albero Filipa Raposo Pereira Rubn Herzog Maximilien Chaumon Marion Houot Maxime Locatelli Aurlie Kas Marie-Odile Habert Marc Teichmann Stphane Epelbaum Isabelle Arnulf Delphine Oudiette Thomas Andrillon span classnlm-collab data-hwp-idcollab-1INSIGHT-preAD group, | ||||||||||||||||||
| PRIME AGING BRAIN COGNITION PHYSICAL | |||||||||||||||||||
Mne03-020 | Physical fitness supports brain maintenance and cognitive reserve in cognitively normal aging: a cross-sectional examination | ||||||||||||||||||
| Quote: | Conclusion Muscular capacity was linked to lower BG PVS volumes, supporting resistance against pathology, while aerobic fitness related to preserved cortical integrity and tended to act as a CR proxy against MTL tau pathology. Physical fitness may support cerebrovascular and glymphatic function, thereby promoting cognitive resilience and extending healthspan by sustaining functional brain health and mitigating tau-related cognitive decline. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.14.26344098v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.14.26344098v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Svenja Schwarck Niklas Behrenbruch Beate Schumann-Werner Ein N. Molloy Berta Garcia-Garcia Anne Hochkeppler Larissa Fischer Anna-Therese Bchel Enise I. Incesoy Jose Bernal Roberto Duarte Coello Maria d.C. Valds-Hernndez Joanna M. Wardlaw Niklas Vockert Patrick Mller Gusalija Behnisch Barbara Morgado Hermann Esselmann Constanze I. Seidenbecher Bjrn H. Schott Henryk Barthel Osama Sabri Jens Wiltfang Michael C. Kreissl Emrah Dzel Anne Maass, | ||||||||||||||||||
| AGING BRAIN COGNITION | |||||||||||||||||||
Mne03-030 | Lifelong trajectories of modifiable vascular risk factors and relation to cerebral small vessel disease in the Framingham Heart Study | ||||||||||||||||||
| Quote: | Conclusions Individuals following high risk lifetime patterns of vascular risk factors have higher CSVD burden later in life. These results highlight the importance of primordial and primary prevention with sustained risk factor management across the lifespan to mitigate CSVD burden, a strong determinant of stroke and dementia risk. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.16.26344309v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.16.26344309v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Jose R. Romero Adlin Pinheiro Serkalem Demissie Hugo J. Aparicio Vasileios-Arsenios Lioutas Antreas Charidimou Alexa Beiser Oluchi Ekenze Jayandra J. Himali Charles DeCarli Sudha Seshadri Shariq Mohammed, | ||||||||||||||||||
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| PRIME AGING | |||||||||||||||||||
Mnu03-020 | A Novel NAD Supporting Supplement Increased NAD Levels, Improved Well-Being, and Alleviated Aging Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study | ||||||||||||||||||
| Quote: | A key factor in aging and many age-related diseases is the decline in nicotinamide adenine dinucleotide NAD levels. Preclinical studies demonstrate promising results for NAD boosting in improving conditions of disease or aging. ... Conclusions Qualia NAD increased NAD levels, enhanced quality of life in all participants, and alleviated some aging symptoms in females greater than placebo. The increase in NAD levels with Qualia NAD was greater than in most previous clinical trials of NAD supporting products at similar dosing, suggesting potential synergy between NR and the complementary nutrients in the product. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.1101/2025.05.14.25327611v2 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.1101/2025.05.14.25327611v2.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Sarah A. Blomquist Gregory Kelly Sara Ades Christopher R. DAdamo Abhimanyu Ardagh Shawn Ramer William Scuba, | ||||||||||||||||||
| AGING COGNITION PSYCHOLOGY | |||||||||||||||||||
Mpy03-016 | Exploring reward learning disruptions as a possible mechanism underlying neuropsychiatric symptoms in Parkinsons disease | ||||||||||||||||||
| Quote: | Conclusions We found inconsistent relationships between symptoms of apathy, depression, and impulsivity and reward learning performance across two samples of PD patients. While this doesnt rule out the possibility that reward learning impairments contribute to these symptoms, it suggests any effect is likely to be small and overshadowed by other non-measured factors. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.14.26344132v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.14.26344132v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Sophie Sun Madeleine Sharp, | ||||||||||||||||||
| AGING BRAIN COGNITION SLEEP | |||||||||||||||||||
Mpy03-022 | Cross-sectional and longitudinal associations between sleep disturbances and psycho-affective symptoms in older adults: influence of amyloid positivity | ||||||||||||||||||
| Quote: | Conclusions: In cognitively unimpaired older adults, associations between sleep disturbances and psycho-affective symptoms differ according to A#946; status. In A#946; individuals specifically, objective sleep fragmentation and instability are linked to psycho-affective vulnerability and brooding worsening over time. Sleep disturbances could thus represent early modifiable targets to mitigate psycho-affective symptomatology in older adults. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.01.15.26344227v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.01.15.26344227v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Claire Andr Edelweiss Touron Antoine Garnier-Crussard Andre-Ann Baril Gal Chtelat Sophie Dautricourt Natalie L. Marchant Graldine Rauchs span classnlm-collab data-hwp-idcollab-1Medit-Ageing Research Group, | ||||||||||||||||||
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01/24/2026-02:51:25 AM
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