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BRAIN
CANCER
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Mca04-022 | Extracellular Vesicle-Associated Syndecan-1 Differentiates Pediatric Brain Tumor Patients with High-Grade from Low-Grade Pilocytic Astrocytoma |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344286v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344286v1.full-text |
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Jonas Klejs Hemmingsen Josephine Elgaard Johansen Mads Zippor Bradley Joseph Whitehead Anders Toftegaard Boysen Hannah Weissinger Mette Galsgaard Malle Kenneth A Howard Srinivas Gopala Peter Nejsum Torben Stamm Mikkelsen Vineesh Indira Chandran,
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AGING
BRAIN
DIAGNOSTICS
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Mcr04-006 | Brain Perivascular Spaces Reflect Neuropsychological and Shared Familial Microvascular Architecture Beyond Vascular Risk |
| Quote: | Conclusions PVS morphology reflects neuropsychiatric and shared familial microvascular architecture, with both inherited and individual factors contributing to PVS burden and morphometry, and supporting the use of PVS morphometry as a neuroimaging marker of cerebral microvascular health.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344665v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344665v1.full-text |
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Alexandra Morozova Maria del C. Valds Hernndez ROBERTO DE JESUS DUARTE COELLO Heather Whalley Andrew McIntosh Anca-Larisa Sandu Gordon Waiter Christopher J. McNeil Douglas Steele Jennifer A Macfarlane Alison D Murray Joanna M. Wardlaw,
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AGING
BRAIN
COGNITION
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Mcr04-024 | Stroke Subtypes Drive Distinct Neurological, Cognitive, and Mortality Outcomes in UK Biobank Cohort |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344805v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344805v1.full-text |
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| Search Authors: |
Ambika Grover Venkatesh L. Murthy Chirag J. Patel,
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AGING
BRAIN
COGNITION
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Mne04-002 | Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK Biobank |
| Quote: | suggesting that unfavorable lifestyle may have a greater impact in individuals without genetic risk. No significant interactions were found in cognitive or imaging models. Conclusion: The APOE #1013;4 genotype was the strongest single predictor of dementia and cognitive outcomes. In contrast, the LIBRA2 index was most strongly associated with processing speed and neuroimaging markers, demonstrating its critical role in non-diagnostic brain health outcomes. These findings highlight the complementary and domain-specific contributions of genetic and lifestyle factors in dementia risk modeling.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.23.26344680v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.23.26344680v1.full-text |
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Yidan Zhang Gamze Erzin Colin Rosenau Sebastian Kohler Dennis van der Meer Jurjen J Luykx David E.J Linden Bart P.F Rutten Sinan Guloksuz Gabriella A.M Blokland,
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AGING
BRAIN
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Mne04-020 | Increased aperiodic offset and heightened alpha power characterize resting-state EEG activity in Parkinsons disease |
| Quote: | esults Aperiodic offset and alpha power were higher in patients than controls across all channels BF1072.41; BF1020.45 and when restricting analysis to pericentral sensorimotor channels BF1063.01; BF1012.06. These differences were expressed in patients with and without levodopa-induced dyskinesias and replicated at follow-up. In patients, aperiodic offset and exponent, but not periodic alpha or beta power, scaled positively with age and disease duration BF102.169.76. Conclusions PD is associated with changes in resting-state brain activity, reflected in both aperiodic and periodic EEG activity. The finding that aperiodic parameters scale with age and disease duration suggests that aperiodic EEG features may serve as markers of disease progression, complementing traditional periodic measures.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.20.26343832v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.20.26343832v1.full-text |
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Salvatore Bertino Amin Ghaderi-Kangavari David Meder Mikkel Christoffer Vinding Nora Raaf Lasse Christiansen Birgitte Liang Chen Thomsen Annemette Lkkegaard Angelo Quartarone Mikkel Malling Beck Hartwig Roman Siebner,
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AGING
BRAIN
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Mne04-026 | Intracerebral hemorrhage induces monocyte TNF signaling that is suppressed by Siponimod BAF312: a single-cell transcriptomics study in patients |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344292v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344292v1.full-text |
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Jonathan Howard DeLong Sebastian Diaz-Perez Kevin N Sheth Jang-Ho Cha CJ Malanga Patricia GM Wagner Nicole Pezous Aurelie Hanin Kyle B Walsh H.E. Hinson Lauren Hachmann Sansing,
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AGING
BRAIN
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Mne04-034 | Orthostatic hypotension in Parkinsons disease impacts the association between white matter lesion volume and motor symptom burden |
| Quote: | Conclusions The presence of OH in PWP impacts the links between white matter lesion volume and motor symptom burden. These findings may provide a potential mechanism underlying the poorer disease prognosis among PWP with OH.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344797v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344797v1.full-text |
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John DAmico Miriam Sklerov Eran Dayan,
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AGING
BRAIN
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Mne04-036 | Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimers disease |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344738v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344738v1.full-text |
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Konstantinos Chiotis Ganna Blazhenets David N. Soleimani-Meigooni Paul S. Aisen Alinda Amuiri Alireza Atri Laurel Beckett Michael Brickhouse David G. Clark Jeffrey L. Dage Gregory S. Day Ranjan Duara Ani Eloyan Tatiana Foroud Neill R. Graff-Radford Ian M. Grant Dustin B. Hammers Lawrence S. Honig Erik C. B. Johnson David T. Jones Kala Kirby Robert Koeppe Joel H. Kramer Walter A. Kukull Julien Lagarde Antoine Leuzy Piyush Maiti Joseph C. Masdeu Mario F. Mendez Erik Musiek Kelly N. Nudelman Chiadi U. Onyike Meghan Riddle Salma Rocha Emily Rogalski Stephen Salloway Daniel R. Schonhaut Sharon Sha Ranjani Shankar Alexander Taurone Maryanne Thangarajah Arthur W. Toga Alexandra Touroutoglou Raymond Scott Turner Prashanthi Vemuri Thomas S. Wingo David A. Wolk Kyle Womack Jiaxiuxiu Zhang Maria C. Carrillo Bradford C. Dickerson Liana G. Apostolova Renaud La Joie Gil D. Rabinovici span classnlm-collab data-hwp-idcollab-1the Longitudinal Early-onset Alzheimers Disease Study consortium and the Alzheimers Disease Neuroimaging Initiative,
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BRAIN
PSYCHOLOGY
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Mpy04-004 | A standard coil placement for reliable transcranial magnetic stimulation of the frontoparietal depression network: the F5-AF7 method |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344778v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.25.26344778v1.full-text |
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Maximilian Lueckel Kathrin Kachel Jan Engelmann Til Ole Bergmann Florian Mueller-Dahlhaus,
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BRAIN
PSYCHOLOGY
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Mpy04-024 | Transient frontal spectral events from EEG predict antidepressant response to sertraline in depression |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.26.26344862v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.26.26344862v1.full-text |
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Darcy A Waller Linda L Carpenter Stephanie R Jones,
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AGING
BRAIN
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Mre04-002 | Differential Effects of Cognitive vs. Motor Dual-Task Training in Stroke Rehabilitation: A Precision-Focused Meta-Analysis |
| Quote: | These results offer crucial prescriptive insights, guiding clinicians to match the dual-task modality and timing of intervention to the individual patients functional profile. However, the high heterogeneity among studies and the lack of direct comparative trials between CDT and MDT limit the conclusive strength of these recommendations.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.23.26344517v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.23.26344517v1.full-text |
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Hui Gao Man Lang Mustapha Mangdow Wen Liu,
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AGING
BRAIN
LANGUAGE
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Mre04-004 | Machine Learning Driven Therapy Calculator for Self-Managed Digital Speech-Language Therapy for Individuals with Post-stroke Aphasia |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344656v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.22.26344656v1.full-text |
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Hantian Liu Margrit Betke Prakash Ishwar Swathi Kiran,
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