PRIME CANCER
Aab04-004	Some Cancers Being Killed with Antiparasitic Fenbendazole
	Quote:	Her husband administered her 222 mg fenbendazole powder each morning in her yogurt. After a few weeks her appearance, activity level and outlook all dramatically improved. She soon dismissed hospice. Within 3-4 months her blood tumor markers dropped to within normal limits and imaging confirmed that the cancer in her liver, bones and lungs was gone.
	Article:	https://principia-scientific.com/some-cancers-being-killed-with-antiparasitic-fenbendazole/
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PRIME CANCER
Aac04-006	Are We Close to a Cure for One of the Most Aggressive Forms of Cancer?
	Quote:	In most pancreatic cancer cases, the KRAS oncogene gene mutates. The combination of the three drugs involved in the therapy daraxonrasib an experimental KRAS blocker, afatinib an approved drug for certain lung cancers that shuts down EGFR signals, and SD36 which knocks out STAT3, a backup survival protein tumors use to resist treatment hit it at three critical points at once. When tested in mice, it wiped out the pancreatic tumors completely with no regrowth for an extended period that would equal many years in a human lifespan.
	Article:	ttps://pjmedia.com/sarah-anderson/2026/01/28/are-we-close-to-a-cure-for-one-of-the-most-aggressive-forms-of-cancer-n4948872
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CANCER DIAGNOSTICS GENETICS
Mca04-002	Whole Genome Sequencing Informed Patient Personalized Measurable Residual Disease Assays for Acute Myeloid Leukemia
	Quote:	In this study, we demonstrate a whole genome sequencing WGS-based approach to identify genomic DNA breakpoints of chromosomal rearrangements that allowed design of highly sensitive patient-personalized digital droplet PCR ddPCR MRD assays.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.22.26343677v2
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.22.26343677v2.full-text
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	Search Authors:	Niveditha Ravindra Justin Lack Clifton L Dalgard Eddy vanCollenburg Adam Corner Lan Beppu Harry Erba Megan Othus Jerald P Radich Laura W Dillon Christopher S Hourigan,
CANCER DIAGNOSTICS
Mca04-008	Secretory acid sphingomyelinase activity is elevated in persons with colorectal neoplasia
	Quote:	Conclusions Together, these studies suggest the potential for S-SMase activity to serve as a biomarker for colorectal neoplasia, with potential implications in some but perhaps not all populations.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.22.26344557v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.22.26344557v1.full-text
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	Search Authors:	Justin M Snider Elisabeth K Batzli Madison L Hannan Aki Hara Quiming Wang Juanita L Merchant Xavier Llor Rosa M Xicola Elizabeth T Jacobs Peter Lance Nathan A Ellis Ashley J Snider,
CANCER REPRODUCTION
Mca04-010	A Three-subtype Molecular model of Cervical Cancer: Multiple PI3K Pathway inhibitors suppress growth and cooperate with HPV-directed immunotherapy
	Quote:	Conclusions Our study revealed molecular inhibitors targeting mutant PIK3CA cervical cancer. When combined with immune therapies, these agents may improve outcomes of advanced HPV16 cancers. Further research on targeted therapies will improve the prognosis of patients with cervical cancer.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.21.26344562v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.21.26344562v1.full-text
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	Search Authors:	Hong Lou David Langan Nicholas Syracuse Elizabeth Murphy Sojung Kim Emma Robinson Nicole Rossi Yi Xie Sonam Tulsyan Tawnjerae Joe Isabel Rodriguez Nina Rao Matt Oberley Mathias Oelke Michael Dean,
BRAIN CANCER
Mca04-022	Extracellular Vesicle-Associated Syndecan-1 Differentiates Pediatric Brain Tumor Patients with High-Grade from Low-Grade Pilocytic Astrocytoma
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.22.26344286v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.22.26344286v1.full-text
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	Search Authors:	Jonas Klejs Hemmingsen Josephine Elgaard Johansen Mads Zippor Bradley Joseph Whitehead Anders Toftegaard Boysen Hannah Weissinger Mette Galsgaard Malle Kenneth A Howard Srinivas Gopala Peter Nejsum Torben Stamm Mikkelsen Vineesh Indira Chandran,
CANCER
Mga04-006	A Novel Host Stool mRNA Extraction Method Improves Sensitivity of Detection for Colorectal Cancer and Precancerous Lesions
	Quote:	RESULTS ECB-Extract significantly improved PCR inhibitor removal, enabling scale-up of stool input and resulting in increased diagnostic sensitivity. We evaluated ECB-Extract against a conventional phenol-chloroform-based extraction method using the same panel of biomarkers in a pilot clinical cohort N 73. Using ECB-Extract, the sensitivity for detecting CRC and Advanced Precancerous Lesions APL was 96 and 50, respectively, compared with 56 and 21 for the phenol-chloroform comparator at 96 specificity.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.01.20.25342587v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.01.20.25342587v1.full-text
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	Search Authors:	Jakob Kirchner Haijiu Lin Loren Hansen Janet Cheng Changpu Song Kristin Ramos Dan Chen Yanyang Liang Wenying Pan,

Updated weekly. 01/31/2026-02:32:41 AM
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What interests you?

Aab04-004

Some Cancers Being Killed with Antiparasitic Fenbendazole

Aac04-006

Are We Close to a Cure for One of the Most Aggressive Forms of Cancer?

Mca04-002

Whole Genome Sequencing Informed Patient Personalized Measurable Residual Disease Assays for Acute Myeloid Leukemia

Mca04-008

Secretory acid sphingomyelinase activity is elevated in persons with colorectal neoplasia

Mca04-010

A Three-subtype Molecular model of Cervical Cancer: Multiple PI3K Pathway inhibitors suppress growth and cooperate with HPV-directed immunotherapy

Mca04-022

Extracellular Vesicle-Associated Syndecan-1 Differentiates Pediatric Brain Tumor Patients with High-Grade from Low-Grade Pilocytic Astrocytoma

Mga04-006

A Novel Host Stool mRNA Extraction Method Improves Sensitivity of Detection for Colorectal Cancer and Precancerous Lesions