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Scanned: 2728
Evaluated: 299
Selected: 66
 
    HEART    METABOLISM   

Mep04-038

ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITS

Quote:Mitochondrial heteroplasmic variant has been increasingly recognized as a potential contributor to common complex diseases, ... We identified twelve significant gene-trait associations after Bonferroni correction, with consistent effect directions across coding definitions. The strongest association was observed between hyperlipidemia and heteroplasmic variants in CO1 gene OR0.28, 95 CI0.17, 0.46, p3.4E-7 among EA European Americans. Additional associations were detected for BMI, adjusted SBP systolic blood pressure, BG blood glucose, diabetes, and adjusted LDL. These findings highlight the contribution of heteroplasmic variation within mtDNA to cardiometabolic phenotypes and provide new insight into mitochondrial involvement in CMD pathophysiology.
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.23.26344724v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.23.26344724v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Xianbang Sun Xue Liu Katia Bulekova Achilleas N Pitsillides Xiuqing Guo Yong Qian Laura M Raffield Jerome I Rotter Stephen S Rich Goncalo Abecasis April P Carson Ramachandran S Vasan Joshua C Bis Bruce M Psaty Eric Boerwinkle Annette L Fitzpatrick Claudia L Satizabal Dan E Arking Jun Ding Daniel Levy span classnlm-collab data-hwp-idcollab-1TOPMed mtDNA working group Chunyu Liu, 
    METABOLISM    PSYCHOLOGY   

Mpy04-014

NIMETOX-informed Precision Nomothetic Models of Major Depressive Disorder: Group, Phenome, and Individual Signatures

Quote:The various NIMETOX pathways mediate the impact of adverse childhood experiences on metabolomics and MDD. Conclusions: MDD is a NIMETOX disorder in which metabolomic signals represent a final common pathway underlying symptom severity, recurrence of illness, and suicidality.
Comment: depression
Abstract: https://www.medrxiv.org/content/10.64898/2026.01.23.26344678v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.01.23.26344678v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Michael Maes Mengqi Niu Ping Wang Annabel Maes Yiping Luo Chenkai Yangyan Xiaoman Zhuang Abbas F. Almulla Jing Li Yingqian Zhang, 
See Also:
  • MDD+Mahjor+Depressive+Disorder: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 

    •   Updated weekly. 01/31/2026-02:32:41 AM
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