|
AGING
BRAIN
|
Mne05-002 | Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases |
| Quote: | An early cortico-limbic/late basal ganglia subtype represented a dementia-prone subtype across clinical diagnoses, with limbic involvement associating with the emergence of visual hallucinations. These biologically relevant spatiotemporal atrophy subtypes provide an interpretable stratification of patients with LBD, with potential to refine prognosis, improve clinical trial stratification, and guide precision therapeutic approaches.
|
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.01.29.26344990v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.01.29.26344990v1.full-text |
| Search Similar: |
Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho |
| Search Authors: |
Ajay Konuri Gonzalo Castro Leal Niloufar Zebarjadi Annegret Habich Nicolas Castellanos-Perilla Maria Camila Gonzalez John-Paul Taylor Michael Firbank Daniel Alcolea Alexandre Bejanin Kurt Segers Florence Benoit Ahmet Turan Isik Bedia Samanci Consuelo Chafer-Pericas Richard Wade-Martins Michele T M Hu Rohan Bhome Ivelina Dobreva Zuzana Walker Dag Aarsland Eric Westman Daniel Ferreira Glenda Halliday Simon JG Lewis Rimona S Weil Ramon Landin-Romero Christian Lambert Neil P Oxtoby Elie Matar,
|
|
AGING
BRAIN
|
Mne05-026 | CSF turnover reshapes biomarker interpretation in neurodegeneration studies |
| Quote: | Cerebrospinal fluid CSF biomarkers are central to Alzheimers disease AD diagnosis and research. ... CSF turnover/clearance severely impacted core AD biomarker levels, affecting the classification of subjects in the A/T framework. Adjusting biomarker levels for OPCML, a novel reference marker, improved biomarker-based prediction of AD progression and removed confounded associations, revealing a proteomic signature of sporadic AD pathology that closely resembles that of autosomal dominant AD.
|
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.02.26345363v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.02.26345363v1.full-text |
| Search Similar: |
Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho |
| Search Authors: |
Pablo Garcia-Gonzalez Raquel Puerta Jonas Dehairs Chengran Yang Ciyang Wang Jigyasha Timsina Itziar de Rojas Claudia Olive Alejandro Valenzuela Paula Bayon-Bujan Marta Rovira Laura Montrreal Maria Capdevila Alvaro Munoz-Morales Berta Calm Sergi Valero Montse Alegret Marta Marquie span classnlm-collab data-hwp-idcollab-1The Global Neurodegeneration Proteomics Consortium GNPC John C Morris Suzanne E Schindler David M Holtzman Pilar Sanz Lluis Tarraga Asif Khan Maria Eugenia Saez Bart Smets Adelina Orellana Xavier Montalban Merce Boada Amanda Cano Menghan Liu Muhammad Ali Carlos Cruchaga Johannes V Swinnen Victoria Fernandez Alfredo Cabrera-Socorro Agustin Ruiz,
|